2019
DOI: 10.1002/jcp.29047
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YAP1 is required for the angiogenesis in retinal microvascular endothelial cells via the inhibition of MALAT1‐mediated miR‐200b‐3p in high glucose‐induced diabetic retinopathy

Abstract: Diabetic retinopathy (DR) is one of the severest complications in the development of diabetes with a characteristic of intraretinal new vessel formation. Our present study attempts to probe into the involvement of Yes-associated protein 1 (YAP1) in retinal microvascular endothelial cells (RMECs) and the underlying mechanism. The DR mouse model was induced by streptozotocin injection and a high-glucose/ high-fat diet. After that, with the utilization of the Pearsonʼs correlation analysis, the correlation betwee… Show more

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Cited by 43 publications
(39 citation statements)
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References 29 publications
(38 reference statements)
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“…Zhu et al have found that MALAT1 exerts its roles via interacting with miR-143 in cervical carcinoma cells [31]. It is further confirmed that MALAT1 indirectly modulate VEGFA via miR-200b-3p [32]. Moreover, another study has suggested that miR-143-3p mediates ZFPM2 effect on a number of protein targets in blood, including VEGFA [33].…”
Section: Discussionmentioning
confidence: 88%
“…Zhu et al have found that MALAT1 exerts its roles via interacting with miR-143 in cervical carcinoma cells [31]. It is further confirmed that MALAT1 indirectly modulate VEGFA via miR-200b-3p [32]. Moreover, another study has suggested that miR-143-3p mediates ZFPM2 effect on a number of protein targets in blood, including VEGFA [33].…”
Section: Discussionmentioning
confidence: 88%
“…The lncRNA-associated competing endogenous RNA (ceRNA) network has attracted much attention recently [12,[32][33][34]. Series of records have proved that MALAT1 play a prominent role in cell proliferation, differentiation and angiogenesis by functioning as a ceRNA [40].…”
Section: Discussionmentioning
confidence: 99%
“…VEGFA has been acknowledged as a downstream pro-angiogenesis factor of MALAT1 [32]. MALAT1 prompts the expression of VEGFA to modulate angiogenesis and epithelial-mesenchymal transition [33,34]. It can be recruited to VEGFA pre-mRNA and control the expression of VEGFA isoforms [35].…”
Section: Discussionmentioning
confidence: 99%
“…The relationship between miR-200b-3p and MALAT1 or vascular endothelial growth factor A (VEGFA) was validated in a DR mouse model that was induced by streptozotocin injection and a high-glucose/high-fat diet and in retinal microvascular endothelial cells (RMECs) (24).…”
Section: Altered Intracellular Expression Levels Of Mirnas Play a Role In Drmentioning
confidence: 99%