YAP suppresses human T‐cell leukemia virus type 1 transcription
Hengbo Li,
Feng Zou,
Jie Zhang
et al.
Abstract:Human T‐cell leukemia virus type 1 (HTLV‐1) is an oncogenic retrovirus that causes adult T‐cell leukemia/lymphoma (ATL). HTLV‐1 encodes Tax protein that activates transcription from viral long terminal repeats (LTR). Multiple cofactors are involved in the regulation of HTLV‐1 transcription via association with Tax. Yes‐associated protein (YAP), which is the key effector of Hippo pathway, is elevated and activated in ATL cells. In this study, we reported that YAP protein suppressed Tax activation of HTLV‐1 5′ L… Show more
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