YAP Expression in Normal and Neoplastic Breast Tissue: An Immunohistochemical Study

Jaramillo-Rodríguez, Yolanda; Cerda‐Flores, Ricardo M.; Ruíz-Ramos, Rubén; López-Márquez, Francisco Carlos; Calderón-Garcidueñas, Ana Laura

doi:10.1016/j.arcmed.2014.01.010

Cited by 26 publications

(30 citation statements)

References 14 publications

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“…Our results suggest that YAP acts as a tumor suppressor because the BC tissue assessed reveals a lower YAP expression compared with normal breast tissue, which in turn, the YAP binding to the p53 family member p73 decreases the ability of p73 to induce apoptosis in response to DNA damage as suggested by Strano et al (2001). In addition, and because YAP acts as a tumor suppressor, some authors using immunohistochemistry, have described a significant decrease of YAP protein expression in tumors ( Jaramillo-Rodrıguez, et al, 2014;Tufail et al, 2012;Yuan et al, 2008), and loss of heterozygosity analysis has revealed that protein loss correlates with specific deletion of the YAP gene locus, these findings support a role as tumor suppressor gene (Yuan et al, 2008). Normally, YAP is distributed in the cytoplasm and in the nucleus; however, the expression of YAP in the nucleus of normal tissue likely represents the normal physiologic function of YAP (Ideker et al, 2001), where it plays an important role in the cellular homeostasis (Dong et al, 2007;Pan, 2007).…”

Section: Discussionmentioning

confidence: 61%

“…(). In addition, and because YAP acts as a tumor suppressor, some authors using immunohistochemistry, have described a significant decrease of YAP protein expression in tumors (Jaramillo‐Rodrıguez, et al ., ; Tufail et al ., ; Yuan et al ., ), and loss of heterozygosity analysis has revealed that protein loss correlates with specific deletion of the YAP gene locus, these findings support a role as tumor suppressor gene (Yuan et al ., ).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that an abnormal YAP expression is associated with BC, and based on its expression level, YAP has been proposed to act as both a tumor suppressor (lower YAP expression) ( Jaramillo-Rodrıguez, et al, 2014;Tufail et al, 2012;Yuan et al, 2008) and an oncogene (increased YAP expression) (Vlug et al, 2013;Wang et al, 2012;Zhi et al, 2012). Our results suggest that YAP acts as a tumor suppressor because the BC tissue assessed reveals a lower YAP expression compared with normal breast tissue, which in turn, the YAP binding to the p53 family member p73 decreases the ability of p73 to induce apoptosis in response to DNA damage as suggested by Strano et al (2001).…”

Section: Discussionmentioning

confidence: 99%

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Association between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levels

et al. 2017

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The Hippo pathway regulates cell proliferation and apoptosis and it has been noted that loss of critical components of this pathway can lead to uncontrolled cell growth. Yap protein is an important component of this HIPPO pathway because YAP is the nuclear effector of the Hippo tumor suppressor pathway and it is crucial for the response to oxidative stress induced by cellular process and for different xenobiotics including arsenic (As). It has been proposed that YAP dysregulation can contribute to a malignant cellular phenotype acting as both a tumor suppressor and an oncogene. The aim of the study was to assess and compare the expression of YAP in neoplastic and non-neoplastic breast tissue of women chronically exposed to As through drinking water. YAP expression was assessed by immunohistochemistry in 120 breast biopsies from women with breast cancer and from women with other non-neoplastic breast pathologies. Arsenic concentration was quantified in urine and toenails. The results disclosed a lower percentage of YAP expression in the nucleus and in the cytoplasm in cases when compared to the registered in controls. High As levels decreases mainly YAP expression at the nucleus. YAP high intensity staining decreases the risk for breast cancer. The overall data suggest that YAP may acts as a tumor suppressor protein and that As is able to reduce the YAP translocation from the cytoplasm to the nucleus which can induce an environment favorable for inhibition of apoptosis and promoting cellular proliferation by increasing the genomic instability of cells.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levels

et al. 2017

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“…It was reported that the expression of YAP is decreased in breast tumor tissues compared with normal breast tissues [84,85]. Yuan et al [86] found that YAP knockdown protected MDA-MB-231 cells from anoikis and promoted cell migration, invasion, and tumor growth.…”

Section: The Hippo Pathway Plays Important Roles In Breast Cancermentioning

confidence: 99%

Hippo pathway in mammary gland development and breast cancer

Shi

Feng

Chen

2015

ABBS

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Accumulated evidence suggests that the Hippo signaling pathway plays crucial roles in mammary gland development and breast cancer. Key components of the Hippo pathway regulate breast epithelial cell proliferation, migration, invasion, and stemness. Additionally, the Hippo pathway regulates breast tumor growth, metastasis, and drug resistance. It is expected that the Hippo pathway will provide novel therapeutic targets for breast cancer. This review will discuss and summarize the roles of several core components of the Hippo pathway in mammary gland development and breast cancer.

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“…This alternate function of YAP has been noted in few morphologic studies of breast and prostate cancer, which have shown that YAP expression is lost in the tumor cells and retained in normal tissues. 15,16 YAP has also been noted to induce apoptosis in several hematologic malignancies. 17 This dual role as an oncogene as well as tumor suppressor gene makes it similar to FAT atypical cadherin 1, and may be related to its phosphorylation status and nuclear versus cytoplasmic localization as shown in a subset of head and neck squamous cell carcinomas.…”

Section: Hippo Pathway and Cancermentioning

confidence: 99%

YAP and the Hippo pathway in pediatric cancer

Ahmed

Mohamed

Gener

et al. 2017

Molecular & Cellular Oncology

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The Hippo pathway is an important signaling pathway that controls cell proliferation and apoptosis. It is evolutionarily conserved in mammals and is stimulated by cell-cell contact, inhibiting cell proliferation in response to increased cell density. During early embryonic development, the Hippo signaling pathway regulates organ development and size, and its functions result in the coordinated balance between proliferation, apoptosis, and differentiation. Its principal effectors, YAP and TAZ, regulate signaling by the embryonic stem cells and determine cell fate and histogenesis. Dysfunction of this pathway contributes to cancer development in adults and children. Emerging studies have shed light on the upregulation of Hippo pathway members in several pediatric cancers and may offer prognostic information on rhabdomyosarcoma, osteosarcoma, Wilms tumor, neuroblastoma, medulloblastoma, and other brain gliomas. We review the results of such published studies and highlight the potential clinical application of this pathway in pediatric oncologic and pathologic studies. These studies support targeting this pathway as a novel treatment strategy.

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YAP Expression in Normal and Neoplastic Breast Tissue: An Immunohistochemical Study

Cited by 26 publications

References 14 publications

Association between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levels

Association between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levels

Hippo pathway in mammary gland development and breast cancer

YAP and the Hippo pathway in pediatric cancer

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