YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization

Wu, Nan; Xu, Jindong; Du, William W.; Li, Xiangmin; Awan, Faryal Mehwish; Li, Feiya; Mısır, Sema; Eshaghi, Esra; Lyu, Jingjing; Zhou, Le; Zeng, Ke; Adil, Aisha; Wang, Sheng; Yang, Burton B.

doi:10.1016/j.ymthe.2020.12.004

Cited by 66 publications

(53 citation statements)

References 44 publications

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“…Recently, circYap was found to be downregulated in cardiac tissues of patients with cardiac hypertrophy and in a transverse aortic constriction (TAC) mouse model of pressure overload. 96 Delivery of nanoparticle-conjugated circYap plasmids attenuated cardiac fibrosis and improved heart function by decreasing actin polymerization in TAC mice.…”

Section: Targeting Circrnas In Diseasementioning

confidence: 99%

“… 148 Lastly, AuNP-conjugated circYap plasmids significantly attenuated cardiac fibrosis and improved heart functions in a pressure-overload mouse model. 96 The delivery efficiency of circRNA nanoparticles is lower than siRNA and AON nanoparticles. An ongoing area of investigation surrounds the optimization of nanoparticle properties to improve their penetrance into and distribution throughout tumors.…”

Section: Strategies To Target Circrnasmentioning

confidence: 99%

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Targeting circular RNAs as a therapeutic approach: current strategies and challenges

Liu

et al. 2021

Sig Transduct Target Ther

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253

216

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Significant progress has been made in circular RNA (circRNA) research in recent years. Increasing evidence suggests that circRNAs play important roles in many cellular processes, and their dysregulation is implicated in the pathogenesis of various diseases. CircRNAs are highly stable and usually expressed in a tissue- or cell type-specific manner. Therefore, they are currently being explored as potential therapeutic targets. Gain-of-function and loss-of-function approaches are typically performed using circRNA expression plasmids and RNA interference-based strategies, respectively. These strategies have limitations that can be mitigated using nanoparticle and exosome delivery systems. Furthermore, recent developments show that the cre-lox system can be used to knockdown circRNAs in a cell-specific manner. While still in the early stages of development, the CRISPR/Cas13 system has shown promise in knocking down circRNAs with high specificity and efficiency. In this review, we describe circRNA properties and functions and highlight their significance in disease. We summarize strategies that can be used to overexpress or knockdown circRNAs as a therapeutic approach. Lastly, we discuss major challenges and propose future directions for the development of circRNA-based therapeutics.

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Section: Targeting Circrnas In Diseasementioning

confidence: 99%

Section: Strategies To Target Circrnasmentioning

confidence: 99%

Targeting circular RNAs as a therapeutic approach: current strategies and challenges

Liu

et al. 2021

Sig Transduct Target Ther

Self Cite

253

216

View full text Add to dashboard Cite

show abstract

“…CircYap: The Yes-associated protein (YAP) gene generates three circRNAs (circYap) in human cardiac tissue with the highest expression levels of hsa_circ_0002320. CircYap is highly expressed in and downregulated in cardiac hypertrophy [76]. CircYAP inhibits the actin polymerization in cardiac tissue through binding and sequestration of tropomyosin 4 (TPM-4) and gamma actin (ACTG).…”

Section: Cell Morphology and Differentiationmentioning

confidence: 99%

Emerging Role of Circular RNA–Protein Interactions

Das

Sinha

Shyamal

et al. 2021

ncRNA

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Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA–protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered circRNAs. RBPs are a large family of proteins known to play a critical role in gene expression by modulating RNA splicing, nuclear export, mRNA stability, localization, and translation. However, the interaction of RBPs with circRNAs and their implications on circRNA biogenesis and function has been emerging in the last few years. Recent studies suggest that circRNA interaction with target proteins modulates the interaction of the protein with downstream target mRNAs or proteins. This review outlines the emerging mechanisms of circRNA–protein interactions and their functional role in cell physiology.

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“…Subsequent studies unveiled that circYAP acts as a protein scaffold to promote TMP4 and ACTG complexes' formation to inhibit actin aggregation and thus inhibit fibrosis progression. After knockdown of circYAP, actin aggregation efficiency is enhanced and fibrosis accelerated, leading to cardiac hypertrophy's pathological characteristics [91].…”

Section: Circyap and Tmp4/actgmentioning

confidence: 99%

CircRNA-Protein Interactions in Muscle Development and Diseases

Zheng¹,

Zhang²,

Odame³

et al. 2021

Preprint

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Muscle is one of the most critical organs for mammals, which governs multiple movement and physiological functions. Circular RNA (circRNA) is a kind of novel endogenous RNA without 5'-Caps and 3'-poly(A) structures formed by pre-mRNA's back-splicing. RNA binding proteins (RBPs) control the production and degradation of circRNA, help nucleus-cytoplasm transport and locate circRNA, and regulate circRNA translation. Therefore, circRNAs and the chaperoned RBPs play critical roles in muscle growth, development, and disease progression. In this review, we systematically characterize the possible molecular mechanism of circRNA-protein interactions. Also, we summarize the latest researches on circRNA-protein interactions in muscle development and diseases. Besides, we provide several valid prediction methods and experimental verification approaches. Our review reveals the importance of circRNAs and their protein chaperones and provides a reference for further study in this field.

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YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization

Cited by 66 publications

References 44 publications

Targeting circular RNAs as a therapeutic approach: current strategies and challenges

Targeting circular RNAs as a therapeutic approach: current strategies and challenges

Emerging Role of Circular RNA–Protein Interactions

CircRNA-Protein Interactions in Muscle Development and Diseases

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