YAP and TAZ, the conductors that orchestrate eye development, homeostasis, and disease

Zhu, Jianwei; Lin, Sen; Ye, Jian

doi:10.1002/jcp.26870

Cited by 19 publications

(12 citation statements)

References 115 publications

(208 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, six6a correlated with three PKA regulatory subunit genes. It is known that Hippo signaling regulates eye development (Zhu et al 2018b) and that it is activated in embryonic and postnatal pituitary gland (Lodge et al 2016). However, to our knowledge, there are no studies so far linking Six6/Six3 and the Hippo pathway.…”

Section: Discussionmentioning

confidence: 98%

Transcription Profiles of Age-at-Maturity-Associated Genes Suggest Cell Fate Commitment Regulation as a Key Factor in the Atlantic Salmon Maturation Process

Kurko

Debes

House

et al. 2020

G3 Genes|Genomes|Genetics

View full text Add to dashboard Cite

Despite recent taxonomic diversification in studies linking genotype with phenotype, follow-up studies aimed at understanding the molecular processes of such genotype-phenotype associations remain rare. The age at which an individual reaches sexual maturity is an important fitness trait in many wild species. However, the molecular mechanisms regulating maturation timing processes remain obscure. A recent genome-wide association study in Atlantic salmon (Salmo salar) identified large-effect age-at-maturity-associated chromosomal regions including genes vgll3, akap11 and six6, which have roles in adipogenesis, spermatogenesis and the hypothalamic-pituitary-gonadal (HPG) axis, respectively. Here, we determine expression patterns of these genes during salmon development and their potential molecular partners and pathways. Using Nanostring transcription profiling technology, we show development- and tissue-specific mRNA expression patterns for vgll3, akap11 and six6. Correlated expression levels of vgll3 and akap11, which have adjacent chromosomal location, suggests they may have shared regulation. Further, vgll3 correlating with arhgap6 and yap1, and akap11 with lats1 and yap1 suggests that Vgll3 and Akap11 take part in actin cytoskeleton regulation. Tissue-specific expression results indicate that vgll3 and akap11 paralogs have sex-dependent expression patterns in gonads. Moreover, six6 correlating with slc38a6 and rtn1, and Hippo signaling genes suggests that Six6 could have a broader role in the HPG neuroendrocrine and cell fate commitment regulation, respectively. We conclude that Vgll3, Akap11 and Six6 may influence Atlantic salmon maturation timing via affecting adipogenesis and gametogenesis by regulating cell fate commitment and the HPG axis. These results may help to unravel general molecular mechanisms behind maturation.

show abstract

Section: Discussionmentioning

confidence: 98%

Transcription Profiles of Age-at-Maturity-Associated Genes Suggest Cell Fate Commitment Regulation as a Key Factor in the Atlantic Salmon Maturation Process

Kurko

Debes

House

et al. 2020

G3 Genes|Genomes|Genetics

View full text Add to dashboard Cite

show abstract

“…Additionally, six6a correlated with three PKA regulatory subunit genes. It is known that Hippo signaling regulates eye development (85) and that it is activated in embryonic and postnatal pituitary gland (86).…”

Section: Discussionmentioning

confidence: 99%

Transcription profiles of age-at-maturity-associated genes suggest cell fate commitment regulation as a key factor in the Atlantic salmon maturation process

Kurko

Debes

House

et al. 2019

Preprint

View full text Add to dashboard Cite

Despite recent taxonomic diversification in studies linking genotype with phenotype, follow-up studies aimed at understanding the molecular processes of such genotype-phenotype associations remain rare. The age at which an individual reaches sexual maturity is an important fitness trait in many wild species. However, the molecular mechanisms regulating maturation timing processes remain obscure. A recent genome-wide association study in Atlantic salmon (Salmo salar) identified large-effect age-at-maturity-associated chromosomal regions including genes vgll3, akap11 and six6, which have roles in adipogenesis, spermatogenesis and the hypothalamic-pituitary-gonadal (HPG) axis, respectively. Here, we determine expression patterns of these genes during salmon development and their potential molecular partners and pathways. Using Nanostring transcription profiling technology, we show development-and tissue-specific mRNA expression patterns for vgll3, akap11 and six6. Correlated expression levels of vgll3 and akap11, which have adjacent chromosomal location, suggests they may have shared regulation. Further, vgll3 correlating with arhgap6 and yap1, and akap11 with lats1 and yap1 suggests that Vgll3 and Akap11 take part in actin cytoskeleton regulation. Tissue-specific expression results indicate that vgll3 and akap11 paralogs have sexdependent expression patterns in gonads. Moreover, six6 correlating with slc38a6 and rtn1, and Hippo signaling genes suggests that Six6 could have a broader role in the HPG neuroendrocrine and cell fate commitment regulation, respectively. We conclude that Vgll3, Akap11 and Six6 may influence Atlantic salmon maturation timing via affecting on adipogenesis and gametogenesis by regulating cell fate commitment and the HPG axis. These results may help to unravel general molecular mechanisms behind maturation.

show abstract

“…YAP is an important effector of the Hippo pathway, and plays important roles in regulating cell proliferation, migration, and differentiation (Feng et al, 2016; Huang et al, 2016). The role of YAP in organ development, tumorigenesis and metastasis, and regenerative medicine has received increasing attention (Zhu et al, 2018; Moya and Halder, 2019; Wu et al, 2019). YAP, which is a transcriptional coactivator, is distributed in both the nucleus and cytoplasm, and its localization affects its function.…”

Section: Introductionmentioning

confidence: 99%

YAP nuclear‐cytoplasmic translocation is regulated by mechanical signaling, protein modification, and metabolism

Zou

Feng

et al. 2020

Cell Biology International

View full text Add to dashboard Cite

Nuclear‐cytoplasmic transport is necessary for the biological function of nuclear proteins. The mechanism underlying this process is very complex and has been a subject of intense research. Yes‐associated protein (YAP), a Hippo signaling pathway effector, localizes to both the cytoplasm and the nucleus and can influence cell proliferation, stem cell status, and tissue homeostasis. Recent studies have focused on the significance of YAP distribution between the nucleus and the cytoplasm in disease, but it remains unclear how this dynamic process is regulated. In this review, we discuss YAP nuclear‐cytoplasmic transport under different physiological and pathological conditions in terms of mechanical signaling, protein modification, and metabolism. Understanding the mechanisms underlying nuclear‐cytoplasmic YAP transport mechanism under different physiological and pathological conditions may help identify important targets for disease treatment.

show abstract

YAP and TAZ, the conductors that orchestrate eye development, homeostasis, and disease

Cited by 19 publications

References 115 publications

Transcription Profiles of Age-at-Maturity-Associated Genes Suggest Cell Fate Commitment Regulation as a Key Factor in the Atlantic Salmon Maturation Process

Transcription Profiles of Age-at-Maturity-Associated Genes Suggest Cell Fate Commitment Regulation as a Key Factor in the Atlantic Salmon Maturation Process

Transcription profiles of age-at-maturity-associated genes suggest cell fate commitment regulation as a key factor in the Atlantic salmon maturation process

YAP nuclear‐cytoplasmic translocation is regulated by mechanical signaling, protein modification, and metabolism

Contact Info

Product

Resources

About