Yangyin Tongnao granules enhance neurogenesis in the peri-infarct area and upregulate brain-derived neurotrophic factor and vascular endothelial growth factor after focal cerebral ischemic infarction in rats

Wang, Yu; Yang, Jiehong; Du, Haixia; Zhang, Hongbo; Wan, Haitong

doi:10.1007/s11033-019-04824-5

Cited by 13 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, in this study, we found that the BDNF level in the MCAO group was lower than that in the control group. This is also consistent with some other animal experiments [ 45 , 46 ]. Meanwhile, at the downstream of the BDNF/TrkB signaling pathway, the changes in the TrkB level reflected those of BDNF in both our study and others [ 47 , 48 ].…”

Section: Discussionsupporting

confidence: 93%

Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity

et al. 2020

View full text Add to dashboard Cite

Poststroke cognitive impairment (PSCI) is a severe sequela of stroke. There are no effective therapeutic options for it. In this study, we evaluated whether electroacupuncture (EA) on the trigeminal nerve-innervated acupoints could alleviate PSCI and identified the mechanisms in an animal model. The male Sprague-Dawley rat middle cerebral artery occlusion (MCAO) model was used in our study. EA was conducted on the two scalp acupoints, EX-HN3 (Yintang) and GV20 (Baihui), innervated by the trigeminal nerve, for 14 sessions, daily. Morris water maze and novel object recognition were used to evaluate the animal’s cognitive performance. Neuroprotection and synaptic plasticity biomarkers were analyzed in brain tissues. Ischemia-reperfusion (I/R) injury significantly impaired spatial and cognition memory, while EA obviously reversed cognitive deterioration to the control level in the two cognitive paradigms. Moreover, EA reversed the I/R injury-induced decrease of brain-derived neurotrophic factor, tyrosine kinase B, N-methyl-D-aspartic acid receptor 1, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, γ-aminobutyric acid type A receptors, Ca2+/calmodulin-dependent protein kinase II, neuronal nuclei, and postsynaptic density protein 95 expression in the prefrontal cortex and hippocampus. These results suggest that EA on the trigeminal nerve-innervated acupoints is an effective therapy for PSCI, in association with mediating neuroprotection and synaptic plasticity in related brain regions in the MCAO rat model.

show abstract

Section: Discussionsupporting

confidence: 93%

Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Journal of Analytical Methods in Chemistry been extensively applied in the treatment of brain injury [3]. However, there are few reports on the HPLC fingerprint and pharmacological efficacy of YYTN.…”

Section: Discussionmentioning

confidence: 99%

“…However, four kinds of these Chinese herbal medicines except Dendrobii Caulis and Hirudo have been studied as a simplified formula in a lot of research [ 1 , 2 ]. The proportions of herbal composition of Yangying Tongnao (YYTN) simplified prescription are shown in Table 1 [ 3 ]. The efficacy of YYTN has been evaluated by clinical trials and animal experiments.…”

Section: Introductionmentioning

confidence: 99%

“…Previous researches have proved that YYTN had the functions of inhibiting neuronal apoptosis, improving haematological disorders [ 5 ], and is related with antioxidant and anti-inflammatory properties [ 6 ]. As a traditional Chinese herbal formula, YYTN can also improve the neurological deficits after focal cerebral ischemic infarction in rats [ 3 ]. At the same time, it was found that YYTN has protective effect on oxidative stress-induced cerebral ischemia injury in vivo through animal experiments [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spectrum-Effect Relationship between HPLC Fingerprints and Antioxidant Activity of Yangyin Tongnao Prescription

Zhang

Zhao

et al. 2021

Journal of Analytical Methods in Chemistry

Self Cite

View full text Add to dashboard Cite

Yangyin Tongnao (YYTN) prescription is used as a traditional Chinese herbal formula, and it has antioxidant activity that mainly contributes in the treatment of cardiovascular and cerebrovascular diseases. However, the compounds related to its antioxidant activity are still unknown. In the present study, the fingerprints of YYTN extracts under different extraction conditions were obtained by high performance liquid chromatography (HPLC) to identify the common peaks to all the samples processed. A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay and ferric reducing antioxidant power (FRAP) assay were carried out to evaluate the antioxidant activity of the extracts. Spectrum-effect relationship between HPLC fingerprints and antioxidant activity of YYTN was assessed by Pearson product-moment correlation coefficient (PPMCC) and multiple linear regression analysis (MLRA). The results showed that peaks 5, 6, 13, 15, and 24 of the fingerprints were closely connected to antioxidant activity. Five peaks were identified: vanillic acid (P5), puerarin (P7), ferulic acid (P13), daidzein (P21), and formononetin (P23). Our study successfully established the spectrum-effect relationship between HPLC fingerprints and antioxidant activity of YYTN, which provided a general method for establishing quality standards with a combination of chromatography and antioxidant activity.

show abstract

“…Therefore, the clinic mainly focuses on promoting blood circulation to remove stasis, replenishing Qi to nourish blood, and nursing viscera. Extensive clinical and in vivo and in vitro studies have confirmed that prescriptions SiJunZi decoction (Yang et al, 2019), ShengMai san (Li et al, 2013), and YangYin TongNao granules (Wang et al, 2019f) have a significant effect on ischemic stroke. Of course, the regulation of oxidative stress and inflammatory response are also common mechanisms of prescription in the treatment of ischemic brain injury.…”

Section: Prescription and Molecular Mechanisms In Regulating Mptp Opementioning

confidence: 96%

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

Sun

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Mammalian mitochondrial permeability transition pore (MPTP), across the inner and outer membranes of mitochondria, is a nonspecific channel for signal transduction or material transfer between mitochondrial matrix and cytoplasm such as maintenance of Ca 2+ homeostasis, regulation of oxidative stress signals, and protein translocation evoked by some of stimuli. Continuous MPTP opening has been proved to stimulate neuronal apoptosis in ischemic stroke. Meanwhile, inhibition of MPTP overopening-induced apoptosis has shown excellent efficacy in the treatment of ischemic stroke. Among of which, the potential molecular mechanisms of drug therapy for stroke has also been gradually revealed by researchers. The characteristics of multi-components or multitargets for ethnic drugs also provide the possibility to treat stroke from the perspective of mitochondrial MPTP. The advantages mentioned above make it necessary for us to explore and clarify the new perspective of ethnic medicine in treating stroke and to determine the specific molecular mechanisms through advanced technologies as much as possible. In this review, we attempt to uncover the relationship between abnormal MPTP opening and neuronal apoptosis in ischemic stroke. We further summarized currently authorized drugs, ethnic medicine prescriptions, herbs, and identified monomer compounds for inhibition of MPTP overopening-induced ischemic neuron apoptosis. Finally, we strive to provide a new perspective and enlightenment for ethnic medicine in the prevention and treatment of stroke by inhibition of MPTP overopeninginduced neuronal apoptosis.

show abstract

Yangyin Tongnao granules enhance neurogenesis in the peri-infarct area and upregulate brain-derived neurotrophic factor and vascular endothelial growth factor after focal cerebral ischemic infarction in rats

Cited by 13 publications

References 25 publications

Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity

Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity

Spectrum-Effect Relationship between HPLC Fingerprints and Antioxidant Activity of Yangyin Tongnao Prescription

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

Contact Info

Product

Resources

About