YALES2BIO: A General Purpose Solver Dedicated to Blood Flows

Mendez, Simon; Bérod, Alain; Chnafa, Christophe; Garreau, Morgane; Gibaud, Etienne; Larroque, Anthony; Lindsey, Stéphanie E.; Afonso, Marco Martins; Mattéoli, Pascal; Rojano, Rodrigo Méndez; Midou, Dorian; Puiseux, Thomas; Sigüenza, Julien; Taraconat, Pierre; Zmijanović, Vladeta; Nicoud, Franck

doi:10.1002/9781119986607.ch7

Cited by 1 publication

(1 citation statement)

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“…A numerical framework to compute the blood flow within patient-specific human hearts was developed by Chnafa et al (2014). The geometry of the heart cavities and their wall dynamics were extracted from medical images of a patient, and the simulations were made using the in-house YALES2BIO solver (Mendez et al (2022)). The geometric domain is composed by the four pulmonary veins, the left atrium, the left ventricle and the aorta.…”

Section: Methodsmentioning

confidence: 99%

Simulated Increase in Monoarticular Hip Muscle Strength Reduces the First Peak of Knee Compression Forces During Walking

Jolas,

Simonsen,

Andersen

2023

Journal of Biomechanical Engineering

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Reducing compressive knee contact forces (KCF) during walking could slow the progression of knee osteoarthritis. A previous study has shown that compensating for the hip flexion/extension moment could reduce the KCF peak occurring during early-stance (KCFp1). Therefore, this study aimed to identify if monoarticular hip muscle could allow this compensation while considering different walking strategies. Gait trials from 24 healthy participants were used to make musculoskeletal models. Five load-cases were examined: (I) Normal, (II) with an applied external moment compensating for the hip flexion/extension moment, (III-V) three conditions with isolated/combined 30% increase of isometric strength of gluteus medius and maximus. KCF, hip muscle forces, and joint moments were computed. A cluster analysis of the Normal condition was performed with hip and knee flexion/extension moment during KCFp1 as input to examine the influence of walking strategies. The cluster analysis revealed two groups having different hip and knee moments in early-stance [p<0.01]. The reduction in KCFp1 from the normal condition, although present in both groups, was greater for the group with the highest hip and lowest knee flexion/extension moments for all conditions (II: -6.03% versus -21.82% [p<0.001], III: -3.21% versus -1.59%, IV: -3.00% versus -1.76%, V: -6.12 versus -3.09%). This reduction in KCFp1 occurred through a shift in force developed by the hamstrings to the gluteus medius and maximus. Differences between groups suggest that this reduction depends on the walking strategy.

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Section: Methodsmentioning

confidence: 99%