Yakammaoto inhibited human coxsackievirus B4 (CVB4)-induced airway and renal tubular injuries by preventing viral attachment, internalization, and replication

Yen, Ming Hong; Lee, Jia-Jung; Yeh, Chia Feng; Wang, Kuo Chih; Chiang, Ya Wen; Chiang, Lien Chai; Chang, Jung San

doi:10.1016/j.jep.2013.11.049

Cited by 27 publications

(24 citation statements)

References 23 publications

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“…As a result of developments in food research, much work has been done on jujube in recent decades and the nature of the polysaccharides present in jujube has been studied (Li et al, 2007;Zhao et al, 2008). On account of the abundance of polysaccharides in jujube, much attention has been directed to their extensive bioactivities in regard to immunomodulation (Zhang et al, 2013), anti-cancer (Plastina et al, 2012), anti-virus (Yen et al, 2014), and anti-oxidation properties (Shen et al, 2009). Although, jujube fruits can be made into paste, puree, syrup, and preparations to aid digestion and general health, deep-processing jujube products are still rare.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Background: American ginseng (Panax quinquefolius L.) and Chinese jujube (Zizyphus jujuba Mill.) are commonly used in traditional Chinese medicine to enhance immune function. Objective: The present study aimed to develop one Chinese prescription, Shenzao Cha (SZC), consisting of American ginseng and Chinese jujube, and systematically investigate its immunomodulation in healthy ICR mice. Methods: Normal ICR mice received intragastric administration of SZC (1.3, 2.6, and 5.2 g raw material/kg body weight) once daily for four weeks, while a control group received the same amount of sterile water. Results: SZC significantly increased the spleen and thymus indices and T-lymphocyte proliferation, while the T-lymphocyte proliferation in the 5.2 g/kg group was 1.4-fold higher than that in the control. Further, 1.3 g/kg SZC could markedly improve hemolytic activity by 25.2%, and 2.6 g/kg SZC increased the NK cell activity by 78.6% relative to the control. In addition, the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase), that participated in modulating oxidative stress, were significantly increased in the liver, spleen, thymus, and serum, while the contents of malondialdehyde were dramatically decreased. Conclusions: SZC exhibited potent immunomodulatory effects on innate and adaptive immunity in healthy ICR mice, as well as potential antioxidant activity for prevention of oxidative stress, which was suggested to partly contribute to the immune enhancement.

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Section: Introductionmentioning

confidence: 99%

Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice

et al. 2016

J. Zhejiang Univ. Sci. B

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“…4-Hydroxyphenylacetic acid (4-HPA) is an active component of Chinese herb Aster tataricus (fan hun cao) which had been widely used in China for the treatment of pneumonia, HBV, and carcinoma [20,21,22]. Some previous studies reported that 4-HPA, a metabolite of aromatic amino acid catabolism that is secreted in saliva, controlled the NadA gene expression and could become a potential hypopigmenting agent [23,24,25].…”

Section: Introductionmentioning

confidence: 99%

4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats

Liu

Zhang

et al. 2014

IJMS

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4-Hydroxyphenylacetic acid (4-HPA) is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases. The aim of this study is to investigate the effect of 4-HPA on seawater aspiration-induced lung injury. Pulmonary inflammation and edema were assessed by enzyme-linked immunosorbent assay (ELISA), bronchoalveolar lavage fluid (BALF) white cell count, Evans blue dye analysis, wet to dry weight ratios, and histology study. Hypoxia-inducible factor-1α (HIF-1α) siRNA and permeability assay were used to study the effect of 4-HPA on the production of inflammatory cytokines and monolayer permeability in vitro. The results showed that 4-HPA reduced seawater instillation-induced mortality in rats. In lung tissues, 4-HPA attenuated hypoxia, inflammation, vascular leak, and edema, and decreased HIF-1α protein level. In primary rat alveolar epithelial cells (AEC), 4-HPA decreased hypertonicity- and hypoxia-induced HIF-1α protein levels through inhibiting the activations of protein translational regulators and via promoting HIF-1α protein degradation. In addition, 4-HPA lowered inflammatory cytokines levels through suppressing hypertonicity- and hypoxia-induced HIF-1α in NR8383 macrophages. Moreover, 4-HPA decreased monolayer permeability through suppressing hypertonicity and hypoxia-induced HIF-1α, which was mediated by inhibiting vascular endothelial growth factor (VEGF) in rat lung microvascular endothelial cell line (RLMVEC). In conclusion, 4-HPA attenuated inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats.

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“…The majority of coxsackie virus infections are asymptomatic; however, in a few cases such infections can be life-threatening (6). There are a limited number of case reports of any type of renal involvement in patients with coxsackie virus infection, including severe rhabdomyolysis and acute renal failure (7)(8)(9). To the best of our knowledge, this is the first case report of CG associated with coxsackie virus infection.…”

Section: Discussionmentioning

confidence: 99%

Collapsing glomerulopathy with rare associated coxsackie virus infection: A case report

Zhu

Liu

Yuan

et al. 2016

Experimental and Therapeutic Medicine

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A 38-year-old Chinese man was admitted to the Second Xiangya Hospital of the Central South University (Changsha, China) with heavy proteinuria and rapidly progressing renal failure with nephrotic syndrome. An initial renal biopsy identified collapsing glomerulopathy (CG) with characteristic segmental collapse of the glomerular tuft and marked hypertrophy and hyperplasia of the visceral epithelial cells. A second renal biopsy showed dilation of glomerular capillary loops as a result of effective treatment with rapamycin and anti-viral therapy. Serology for the coxsackie virus antibody was positive when the collapsing lesion was present, and became negative following treatment, which indicated a strong association between the development of CG and coxsackie virus infection. To the best of our knowledge, this is the first case report of CG associated with coxsackie virus infection.

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Yakammaoto inhibited human coxsackievirus B4 (CVB4)-induced airway and renal tubular injuries by preventing viral attachment, internalization, and replication

Cited by 27 publications

References 23 publications

Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice

Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice

4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats

Collapsing glomerulopathy with rare associated coxsackie virus infection: A case report

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