YAG laser treatment of experimental bleeding canine gastric ulcers

Johnston, J.H.; Jensen, Dennis M.; Mautner, W; Elashoff, Janet D.

doi:10.1016/0016-5085(80)90921-x

Cited by 40 publications

(6 citation statements)

References 13 publications

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“…Values for absorption and scattering coefficients have yet to be experimentally determined. Reported estimates vary considerably (1,4,5,8,13). The current model should provide a theoretical basis for more precise determination.…”

Section: Resultsmentioning

confidence: 99%

“…FIGURE 4 Theoretical heating pattern of mammalian tissue using a spot size of 2.5-mm with power settings and pulse durations sufficient to bring the surface temperature to 100°C. Nd:YAG, 80 W for 1.5 s, ARG, 8 W for 0.31 s, CO2, I W for 0.28 s. tissue effects have been described extensively in the medical literature (13,14). Comparison of histological observations indicate that the current model provides a reasonable approximation of the size and shape of these lesions throughout a wide range of power settings.…”

Section: Resultsmentioning

confidence: 99%

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Thermal effects of laser radiation in biological tissue

Cummins¹,

Nauenberg²

1983

Biophysical Journal

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Thermal effects of laser radiation in biological tissue

Cummins¹,

Nauenberg²

1983

Biophysical Journal

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“…was added 1171. Animal studies suggest that coaxial C02 enhances efficacy of hemostasis with the superficially penetrating argon laser [20] but experiments with the Nd:YAG laser do not support this hypothesis [21]. Silverstein et a1 [20] assessed the Nd-YAG laser using an early 4" divergent beam using the standard experimental gastric ulcer model.…”

Section: Discussionmentioning

confidence: 99%

“…Johnston et al [21] found Nd:YAG laser photocoagulation highly effective in stopping experimental gastric ulcer bleeding both at laparotomy and endoscopy.…”

Section: Discussionmentioning

confidence: 99%

Influence of Nd:YAG laser power density and coaxial CO₂ on the gastric wall

Joffe

Rao²

1984

Lasers Surg Med

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A detailed understanding is required of the effect of Nd:YAG power density and coaxial CO2 on tissue necrosis in both the acute and healing situation. Lesions were produced by varying peak powers at eight increments of 10 W from 40-110 W/sec for a time duration of 1 sec with and without coaxial CO2 on the rabbit (n = 16) stomach. Surface areas and careful histological examinations were performed at 2 hr and 4 days. In further experiments, a total incident energy of 60 or 120 J with varying peak powers from 30-120 W/sec were applied at a 1-cm distance. The lesion surface area at 1 cm was 21.7 mm2 compared to 12 mm2 when the fiber tip was held 2 cm away (p less than 0.05). Coaxial CO2 at 1 cm reduced the surface area to 10 mm2 (p less than 0.001). There was a positive correlation between surface areas and the incidental power (r = 0.86, p less than 0.01). There was no significant difference in the mean surface area of lesions at 2 hr compared to those at 4 days, nor was there a correlation between the increasing peak powers with the constant incident energy. Histological features were those of coagulative necrosis (81%) with minimal ulceration (1.6%) at 2 hr with ulceration increasing to 22% at 4 days. These results have helped in planning a safe and effective Nd:YAG photocoagulation study in patients in order to obtain maximum hemostasis with minimal tissue injury.

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“…This induces rapid thrombus formation with an adherent layer of fibrin. Linscheer and Fazio [25] reported the effectiveness of this technique in low-flow bleeding from experimentally induced ulcers and erosions but this could not be confirmed by others [26,27]. They used the method endoscopically in 12 patients with upper gastrointestinal bleeding, the type of lesions being unspecified; bleeding from oozing lesions in the stomach and duodenum were stopped without complication.…”

Section: Topical Methodsmentioning

confidence: 98%

Bleeding gastroduodenal ulcers: Nonoperative treatment

Laurence

Cotton

1987

World j. surg.

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Early endoscopy is now standard diagnostic practice in most institutions for assessment of patients with acute upper gastrointestinal bleeding. Definition of the cause of bleeding facilitates management, and the precise appearance of the lesion may give additional prognostic information about the risk of rebleeding. Many endoscopic tools have now been developed for use in attempts to stop bleeding directly, or to reduce the risk of rebleeding. This article reviews the methods that have been described, which range in expense and complexity from lasers, through diathermy and heater probes, to simple injection needles. Despite the difficulties in assessment and a relative lack of controlled trials, it is clear that most methods can be effective, but also that the experience of a team is probably more important than the choice of probe. Guidelines for selection of patients will continue to evolve. The concept of high‐risk patients with high‐risk lesions provides a valuable framework for stratification. Endoscopic hemostasis is simply a new way of applying surgery. Close collaboration between gastroenterology and surgical teams is essential for future progress in this field.

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YAG laser treatment of experimental bleeding canine gastric ulcers

Cited by 40 publications

References 13 publications

Thermal effects of laser radiation in biological tissue

Thermal effects of laser radiation in biological tissue

Influence of Nd:YAG laser power density and coaxial CO₂ on the gastric wall

Bleeding gastroduodenal ulcers: Nonoperative treatment

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YAG laser treatment of experimental bleeding canine gastric ulcers

Cited by 40 publications

References 13 publications

Thermal effects of laser radiation in biological tissue

Thermal effects of laser radiation in biological tissue

Influence of Nd:YAG laser power density and coaxial CO2 on the gastric wall

Bleeding gastroduodenal ulcers: Nonoperative treatment

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Influence of Nd:YAG laser power density and coaxial CO₂ on the gastric wall