Yacon leaf extract supplementation demonstrates neuroprotective effect against memory deficit related to β-amyloid-induced neurotoxicity

Martinez-Oliveira, Patrícia; Oliveira, Micaela Federizzi de; Alves, Niége; Coelho, Ritiéle Pinto; Pilar, Bruna Cocco; Güllich, Angélica Aparecida da Costa; Ströher, Deise Jaqueline; Boligon, Aline Augusti; Piccoli, Jacqueline da Costa Escobar; Mello‐Carpes, Pâmela Billig; Manfredini, Vanusa

doi:10.1016/j.jff.2018.08.004

Cited by 14 publications

(21 citation statements)

References 57 publications

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“…In the same way, in this study, the hippocampal infusion of Aβ 25–35 promoted hippocampal oxidative stress and damage (increased ROS levels and lipid peroxidation) and decreased the total antioxidant capacity and acetylcholinesterase activity in the hippocampus, leading to STM and LTM recognition deficits. Also, in a previous study, our group performed the histopathological analysis of the cerebral cortex of the rats submitted to the same Aβ hippocampal infusion model and we observed that the cerebral cortex of these rats presented intense deposition of amyloid plaques (Martinez-Oliveria et al, 2018 ).…”

Section: Discussionmentioning

confidence: 92%

The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise

Daré

Garcia

Soares

et al. 2020

Front. Behav. Neurosci.

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Alzheimer's disease (AD) is the leading cause of dementia in the world, accounting for 50-75% of cases. Currently, there is limited treatment for AD. The current pharmacological therapy minimizes symptom progression but does not reverse brain damage. Studies focused on nonpharmacological treatment for AD have been developed to act on brain plasticity and minimize the neurotoxicity caused by the amyloid-beta (Aβ) peptide. Using a neurotoxicity model induced by Aβ in rats, the present study shows that physical (PE) and cognitive exercise (CE) reverse recognition memory deficits (with a prominent effect of long-term object recognition memory), decrease hippocampal lipid peroxidation, restore the acetylcholinesterase activity altered by Aβ neurotoxicity, and seems to reverse, at least partially, hippocampal tissue disorganization.

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Section: Discussionmentioning

confidence: 92%

The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise

Daré

Garcia

Soares

et al. 2020

Front. Behav. Neurosci.

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“…Our data mining has identified 84 metabolites from Peruvian plants previously characterized biochemically from 1970 to 2020 ( Tables S1–S6 ). Then, we filtered these metabolites by their neuroprotective, antihypertensive and antioxidant properties, finding the following native plants: Smallanthus sonchifolius (Yacon) of the family Asteraceae, showing that the antihypertensive and anti-inflammatory properties of the leaf extract on LPS-stimulated mouse microglial cells in vitro [ 42 ] prevented the deposition of amyloid plaques and neurotoxicity because of its antioxidant effect on the hippocampus [ 43 ]. Lepidium meyenii (Maca) is a hypocotyl of the family Brassicaceae with neuroprotective effects due to the inhibition of acetylcholinesterase (AChE) activity, improving scopolamine-induced memory deficits [ 38 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

et al. 2022

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Background: Despite research on the molecular bases of Alzheimer’s disease (AD), effective therapies against its progression are still needed. Recent studies have shown direct links between AD progression and neurovascular dysfunction, highlighting it as a potential target for new therapeutics development. In this work, we screened and evaluated the inhibitory effect of natural compounds from native Peruvian plants against tau protein, amyloid beta, and angiotensin II type 1 receptor (AT1R) pathologic AD markers. Methods: We applied in silico analysis, such as virtual screening, molecular docking, molecular dynamics simulation (MD), and MM/GBSA estimation, to identify metabolites from Peruvian plants with inhibitory properties, and compared them to nicotinamide, telmisartan, and grapeseed extract drugs in clinical trials. Results: Our results demonstrated the increased bioactivity of three plants’ metabolites against tau protein, amyloid beta, and AT1R. The MD simulations indicated the stability of the AT1R:floribundic acid, amyloid beta:rutin, and tau:brassicasterol systems. A polypharmaceutical potential was observed for rutin due to its high affinity to AT1R, amyloid beta, and tau. The metabolite floribundic acid showed bioactivity against the AT1R and tau, and the metabolite brassicasterol showed bioactivity against the amyloid beta and tau. Conclusions: This study has identified molecules from native Peruvian plants that have the potential to bind three pathologic markers of AD.

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“…and endl.) (Smallanthus sonchifolius) extract of the leaf Rat Memory deficits prevented [162] Natural safflower aqueous extract Rat Short and long-term memory improved [163] Methanolic extract of Lactucacapensis thunb. leaves Rat Lowering the degree of lipid peroxidation and protein oxidation [164] Turmeric powder Human Improvement in the quality of life and behavioral symptoms [165] Tabernaemontana divaricata root extract Mouse Prevented memory loss [166] Coconut oil enriched Mediterranean diet Human Enhanced cognitive features [167] Osmotin, a protein derived from Nicotiana tabacum Mouse Increased conduct of random alternation [168] Germinated brown rice SH-SY5Y cells Reduced production of intracellular ROS [169] Isolated from Huperzia serrata is Huperzine A Human Improvement in functions of memory, cognition, and actions [170] Huperzine A isolated from Huperzia serrata Rat Reduce oxidative damage [171] Table 2.…”

Section: Name Of Plant Part Name Of Model Neuroprotective Mechanisms Referencesmentioning

confidence: 99%

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

et al. 2021

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Natural products derived from plants, as well as their bioactive compounds, have been extensively studied in recent years for their therapeutic potential in a variety of neurodegenerative diseases (NDs), including Alzheimer’s (AD), Huntington’s (HD), and Parkinson’s (PD) disease. These diseases are characterized by progressive dysfunction and loss of neuronal structure and function. There has been little progress in designing efficient treatments, despite impressive breakthroughs in our understanding of NDs. In the prevention and therapy of NDs, the use of natural products may provide great potential opportunities; however, many clinical issues have emerged regarding their use, primarily based on the lack of scientific support or proof of their effectiveness and patient safety. Since neurodegeneration is associated with a myriad of pathological processes, targeting multi-mechanisms of action and neuroprotection approaches that include preventing cell death and restoring the function of damaged neurons should be employed. In the treatment of NDs, including AD and PD, natural products have emerged as potential neuroprotective agents. This current review will highlight the therapeutic potential of numerous natural products and their bioactive compounds thatexert neuroprotective effects on the pathologies of NDs.

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Yacon leaf extract supplementation demonstrates neuroprotective effect against memory deficit related to β-amyloid-induced neurotoxicity

Cited by 14 publications

References 57 publications

The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise

The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

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