There is a continued interest to screen plant extracts for their antioxidant properties, in light of the fact that antioxidant activities parallel anticancer activities, amongst their ability to combat other diseases. Cancer is one of the diseases that has a high mortality status in developed countries and is on the rise in developing countries. Plant extracts have been tested for their antimicrobial, anticancer, Antidiabetic, insect repellant and a range of other biological activities. Since 1990s, antioxidant research has expanded significantly, due to its potential benefits in disease prevention and health promotion. Guyana, a country located on the mainland of South America and whose rich diverse flora needs continual screening for plants with a range of pharmaceutical and medicinal activities of which, antioxidant is one. In addition, the isolation of known and unknown natural antioxidants may contribute to novel drug discovery. This article is a mini review of plants/plant extracts that have exhibited antioxidant properties.