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Abstract

Allethrin is a widely used pyrethroid in mosquito coil and has a potential toxic effect. The purpose of the current research was to explore the effects triggered by allethrin-based mosquito coil smoke using an albino wistar rat model on certain biochemical parameters to ascertain the oxidative stress to be the mechanism of insult to testicular tissue. The animals in our study were clustered among the four groups. Group 1 st , with 12 rats represented as control, while group 2 nd having 12 rats, mosquito coil smoke was given to them 8 hours per day, seven days per week for twelve weeks. Group 3 rd with 8 rats having the same exposure as in group 2 nd and then kept for further 8 weeks without any exposure served as the withdrawal group. Group 4 th , a maximum of ten rats with similar treatment as group 2 nd , together with administration of vitamin C. Group 2 nd rats showed derangement in oxidative markers compared to group 1 st , 3 rd , and 4 th as there was a substantial amount of (P<0.001) reduction in glutathione peroxidase (GPX), superoxide dismutase(SOD), catalase(CAT) and reduced glutathione (GSH) activities with a significant rise (P<0.001) in activities of malondialdehyde (MDA). The results of this analysis indicate that vitamin C supplementation is a more effective treatment modality than exposure withdrawal against the oxidative stress triggered by PBMC's smoke in testis of rat.