Y chromosome haplotype reference database (YHRD): Update

Willuweit, Sascha; Roewer, Lutz

doi:10.1016/j.fsigen.2007.01.017

Cited by 312 publications

(184 citation statements)

References 9 publications

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“…The Basque Y-STR-Y-SNP haplotype data have been uploaded to the public database YHRD under accession numbers YA003672-77, YA003718 and YA004063. 14 …”

Section: Methodsmentioning

confidence: 99%

New clues to the evolutionary history of the main European paternal lineage M269: dissection of the Y-SNP S116 in Atlantic Europe and Iberia

et al. 2015

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The dissection of S116 in more than 1500 individuals from Atlantic Europe and the Iberian Peninsula has provided important clues about the controversial evolutionary history of M269. First, the results do not point to an origin of M269 in the FrancoCantabrian refuge, owing to the lack of sublineage diversity within M269, which supports the new theories proposing its origin in Eastern Europe. Second, S116 shows frequency peaks and spatial distribution that differ from those previously proposed, indicating an origin farther west, and it also shows a high frequency in the Atlantic coastline. Third, an outstanding frequency of the DF27 sublineage has been found in Iberia, with a restricted distribution pattern inside this peninsula and a frequency maximum in the area of the Franco-Cantabrian refuge. This entire panorama indicates an old arrival of M269 into Western Europe, because it has generated at least two episodes of expansion in the Franco-Cantabrian area. This study demonstrates the importance of continuing the dissection of the M269 lineage in different European populations because the discovery and study of new sublineages can adjust or even completely revise the theories about European peopling, as has been the case for the place of origin of M269.

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“…The Basque Y-STR-Y-SNP haplotype data have been uploaded to the public database YHRD under accession numbers YA003672-77, YA003718 and YA004063. 14 …”

Section: Methodsmentioning

confidence: 99%

New clues to the evolutionary history of the main European paternal lineage M269: dissection of the Y-SNP S116 in Atlantic Europe and Iberia

et al. 2015

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“…27 Alleles were assigned according to the nomenclature rules as used in the YHRD databank. 28 All haplotypes were submitted to the Whit Athey's Haplogroup Predictor 29 to obtain probabilities for the inferred haplogroups. Based on these results, the samples were assigned to a specific Y-SNP assay to confirm the haplogroup and to assign the sub-haplogroup to the most accurate level of the latest Y-chromosomal tree, according to the updated tree version 1.2 of AMY-tree.…”

Section: Methodsmentioning

confidence: 99%

Genetic genealogy reveals true Y haplogroup of House of Bourbon contradicting recent identification of the presumed remains of two French Kings

et al. 2013

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Genetic analysis strongly increases the opportunity to identify skeletal remains or other biological samples from historical figures. However, validation of this identification is essential and should be done by DNA typing of living relatives. Based on the similarity of a limited set of Y-STRs, a blood sample and a head were recently identified as those belonging respectively to King Louis XVI and his paternal ancestor King Henry IV. Here, we collected DNA samples from three living males of the House of Bourbon to validate the since then controversial identification of these remains. The three living relatives revealed the Bourbon's Y-chromosomal variant on a high phylogenetic resolution for several members of the lineage between Henry IV and Louis XVI. This 'true' Bourbon's variant is different from the published Y-STR profiles of the blood as well as of the head. The earlier identifications of these samples can therefore not be validated. Moreover, matrilineal genealogical data revealed that the published mtDNA sequence of the head was also different from the one of a series of relatives. This therefore leads to the conclusion that the analyzed samples were not from the French kings. Our study once again demonstrated that in order to realize an accurate genetic identification of historical remains DNA typing of living persons, who are paternally or maternally related with the presumed donor of the samples, is required.

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“…To overcome potential bias due to recent historical factors (for example, colonisation by Europeans), the levels of genetic diversity were calculated in different African samples and within each lineage (with n45) after excluding chromosomes that had most likely been recently introduced by Europeans (including haplogroups E1b1b1, F, G, N1c, R1a, R1b1b2 and T). Because chromosomes belonging to haplogroup E1b1b1a-M78 can be considered of either African or European ancestry, a search for identical haplotypes was performed on the YHRD, 36 and only those that did not present a match in European populations were maintained in the analysis.…”

Section: Characterisation Of the Male Lineages Of Equatorial Guineamentioning

confidence: 99%

The genetic landscape of Equatorial Guinea and the origin and migration routes of the Y chromosome haplogroup R-V88

et al. 2012

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Human Y chromosomes belonging to the haplogroup R1b1-P25, although very common in Europe, are usually rare in Africa. However, recently published studies have reported high frequencies of this haplogroup in the central-western region of the African continent and proposed that this represents a 'back-to-Africa' migration during prehistoric times. To obtain a deeper insight into the history of these lineages, we characterised the paternal genetic background of a population in Equatorial Guinea, a Central-West African country located near the region in which the highest frequencies of the R1b1 haplogroup in Africa have been found to date. In our sample, the large majority (78.6%) of the sequences belong to subclades in haplogroup E, which are the most frequent in Bantu groups. However, the frequency of the R1b1 haplogroup in our sample (17.0%) was higher than that previously observed for the majority of the African continent. Of these R1b1 samples, nine are defined by the V88 marker, which was recently discovered in Africa. As high microsatellite variance was found inside this haplogroup in Central-West Africa and a decrease in this variance was observed towards Northeast Africa, our findings do not support the previously hypothesised movement of Chadic-speaking people from the North across the Sahara as the explanation for these R1b1 lineages in Central-West Africa. The present findings are also compatible with an origin of the V88-derived allele in the Central-West Africa, and its presence in North Africa may be better explained as the result of a migration from the south during the mid-Holocene.

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Y chromosome haplotype reference database (YHRD): Update

Cited by 312 publications

References 9 publications

New clues to the evolutionary history of the main European paternal lineage M269: dissection of the Y-SNP S116 in Atlantic Europe and Iberia

New clues to the evolutionary history of the main European paternal lineage M269: dissection of the Y-SNP S116 in Atlantic Europe and Iberia

Genetic genealogy reveals true Y haplogroup of House of Bourbon contradicting recent identification of the presumed remains of two French Kings

The genetic landscape of Equatorial Guinea and the origin and migration routes of the Y chromosome haplogroup R-V88

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