Y-chromosomal STR haplotypes in three ethnic groups and one cosmopolitan population from Tunisia

Cherni, Lotfi; Pereira, Luı́sa; Goios, Ana; Yacoubi-Loueslati, Besma; Khodjet‐El‐Khil, Houssein; Gomes, Iva; Gusmão, Leonor; Alves, Cı́ntia; Slama, Abdelhakim; Amorim, António; Elgaaïed, Amel Benammar

doi:10.1016/j.forsciint.2005.02.007

Cited by 26 publications

(25 citation statements)

References 4 publications

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“…Both French and North African populations have a tumultuous history with various ancestors but the Tunisian population appears to be significantly more heterogeneous as demonstrated by Y-STR diversity in the Sousse population51; the three novel polymorphisms are also in favor of the extreme heterogeneity in the studied cohort (Figure 1)355253. Heterogeneity in haplotype frequencies is often higher in Africans such as the YRI group, in comparison to the European populations who left the African continent and experienced bottlenecks during their migrations, reducing SNPs diversity (Figure 2).…”

Section: Discussionmentioning

confidence: 96%

Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?

Aloui

Sut

Prigent

et al. 2014

Sci Rep

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The CD40 ligand (CD40L/CD154), a member of TNF superfamily, is notably expressed on activated CD4+ T-cells and stimulated platelets. CD40L is linked to a variety of pathologies and to acute transfusion reactions (ATR). Mutations in this gene (CD40LG) lead to X-linked hyper-IgM syndrome. Some CD40LG polymorphisms are associated with variable protein expression. The rationale behind this study is that CD40L protein has been observed to be involved in ATR. We wondered whether genetic polymorphisms are implicated. We investigated genetic diversity in the CD40LG using DHPLC and capillary electrophoresis for screening and genotyping (n = 485 French and Tunisian blood donors). We identified significant difference in the CD40LG linkage pattern between the two populations. Variant minor alleles were significantly over-represented in Tunisian donors (P<0.0001 to 0.0270). We found higher heterogeneity in the Tunisian, including three novel low frequency variants. As there was not a particular pattern of CD40LG in single apheresis donors whose platelet components induced an ATR, we discuss how this information may be useful for future disease association studies on CD40LG.

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Section: Discussionmentioning

confidence: 96%

Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?

Aloui

Sut

Prigent

et al. 2014

Sci Rep

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“…The database included 127 Berbers from Tunisia; 15,16 102 South Tunisians; 17 109 Moroccan Arab and Berber speakers; 18 50 Moroccan and 52 Tunisians (unpublished data). NW African specific haplogroups were identified by further genotyping of samples that were previously described elsewhere.…”

Section: Samplesmentioning

confidence: 99%

Moors and Saracens in Europe: estimating the medieval North African male legacy in southern Europe

et al. 2009

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To investigate the male genetic legacy of the Arab rule in southern Europe during medieval times, we focused on specific Northwest African haplogroups and identified evolutionary close STR-defined haplotypes in Iberia, Sicily and the Italian peninsula. Our results point to a higher recent Northwest African contribution in Iberia and Sicily in agreement with historical data. southern Italian regions known to have experienced long-term Arab presence also show an enrichment of Northwest African types. The forensic and genomic implications of these findings are discussed.

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“…with the exclusion of DYS385) found in the Arab population sample from Algeria and geographical neighbours from north Africa[14,[18][19][20] and southern Europe[21][22][23] are shown inTable S3. Significant R ST values were observed between Algerian Arabs and Berbers from Morocco (R ST = 0.05962; p <0.01) and Tunisia (R ST = 0.02791; p<0.01), whereas the only significant comparisons with non-Berber populations from north Africa were with northern Egyptians (R ST = 0.01996; p <0.05) and Tunisian Andalusians (R ST =0.00962; p<0.05).…”

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confidence: 99%

Analysis of Y-chromosomal SNP haplogroups and STR haplotypes in an Algerian population sample

et al. 2007

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The distribution of Y-chromosomal single nucleotide polymorphism (SNP) haplogroups and short tandem repeat (STR) haplotypes was determined in a sample of 102 unrelated men of Arab origin from northwestern Algeria (Oran area). A total of nine different haplogroups were identified by a panel of 22 binary markers. The most common haplogroups observed in the Algerian population were E3b2 (45.1%) and J1 (22.5%). Y-STR typing by a 17-loci multiplex system allowed 93 haplotypes to be defined (88 were unique). Striking differences in the allele distribution and gene diversity of Y-STR markers between haplogroups could be found. In particular, intermediate alleles at locus DYS458 specifically characterized the haplotypes of individuals carrying haplogroup J1. All the intermediate alleles shared a common repeat sequence structure, supporting the hypothesis that the variant originated from a single mutational event.

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Y-chromosomal STR haplotypes in three ethnic groups and one cosmopolitan population from Tunisia

Cited by 26 publications

References 4 publications

Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?

Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?

Moors and Saracens in Europe: estimating the medieval North African male legacy in southern Europe

Analysis of Y-chromosomal SNP haplogroups and STR haplotypes in an Algerian population sample

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