Y-Cell Receptive Field and Collicular Projection of Parasol Ganglion Cells in Macaque Monkey Retina

Crook, Joanna D.; Peterson, Barry T.; Packer, Orin S.; Robinson, Farrel R.; Troy, John B.; Dacey, Dennis M.

doi:10.1523/jneurosci.2982-08.2008

Cited by 132 publications

(198 citation statements)

References 91 publications

(139 reference statements)

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“…Although the available results are vague, two studies showing striking similarities to our results are worth mentioning. In the studies of parasol retinal ganglion cells in the macaque monkey (homologs of cat's Y cells) (Crook et al, 2008), spike count variance across trials was much lower than its mean (Uzzell and Chichilnisky, 2004). The finding was inconsistent with Poisson statistics but matched a model that included the relative refractory period.…”

Section: Differences Between Cell Classesmentioning

confidence: 95%

Variability of Visual Responses of Superior Colliculus Neurons Depends on Stimulus Velocity

Mochol

Wójcik²,

Wypych³

et al. 2010

J. Neurosci.

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Visually responding neurons in the superficial, retinorecipient layers of the cat superior colliculus receive input from two primarily parallel information processing channels, Y and W, which is reflected in their velocity response profiles. We quantified the timedependent variability of responses of these neurons to stimuli moving with different velocities by Fano factor (FF) calculated in discrete time windows. The FF for cells responding to low-velocity stimuli, thus receiving W inputs, increased with the increase in the firing rate. In contrast, the dynamics of activity of the cells responding to fast moving stimuli, processed by Y pathway, correlated negatively with FF whether the response was excitatory or suppressive. These observations were tested against several types of surrogate data. Whereas Poisson description failed to reproduce the variability of all collicular responses, the inclusion of secondary structure to the generating point process recovered most of the observed features of responses to fast moving stimuli. Neither model could reproduce the variability of low-velocity responses, which suggests that, in this case, more complex time dependencies need to be taken into account. Our results indicate that Y and W channels may differ in reliability of responses to visual stimulation. Apart from previously reported morphological and physiological differences of the cells belonging to Y and W channels, this is a new feature distinguishing these two pathways.

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Section: Differences Between Cell Classesmentioning

confidence: 95%

Variability of Visual Responses of Superior Colliculus Neurons Depends on Stimulus Velocity

Mochol

Wójcik²,

Wypych³

et al. 2010

J. Neurosci.

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show abstract

“…This suggests that as a population, parasol cells do project to the superior colliculus (Crook et al, 2008a).…”

mentioning

confidence: 92%

“…Parasol cells of the primate retina have many properties in common with Y-cells (Crook et al, 2008a). Morphologically, they have large somas, thick axons, and wide dendritic fields.…”

mentioning

confidence: 99%

“…Unexpectedly, when contrast-reversing gratings were presented at high spatial frequencies, every recorded parasol cell displayed the frequency-doubled responses characteristic of Y-cells. These nonlinear responses originated from within the receptive field center, where the strongest Y-cell frequency-doubled responses are elicited (Demb et al, 1999;Crook et al, 2008a).…”

mentioning

confidence: 99%

“…Poor image focus degrades the presentation quality of the high spatial frequencies at which frequency doubling is elicited, and as a result, the magnitude of these nonlinear responses is reduced. By recording in vitro, Crook et al (2008a) could focus stimuli more precisely, thereby eliminating this problem. In addition, the in vitro retina is not continuously subjected to the hyperpolarizing effect of anesthesia (Nicoll and Madison, 1982).…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Primate Retina Contains Distinct Types of Y-Like Ganglion Cells: Figure 1.

Rosenberg

Talebi²

2009

J. Neurosci.

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Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina

Raghuram

Werginz

Fried

et al. 2021

Advanced NanoBiomed Research

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Retinal prostheses are a promising therapeutic intervention for patients afflicted by outer retinal degenerative diseases such as retinitis pigmentosa and age‐related macular degeneration. Although significant advances in the development of retinal implants have been made, the quality of vision elicited by these devices remains largely suboptimal. The variability in the responses produced by retinal devices is most likely due to the differences between the natural cell‐type‐specific signaling that occur in the healthy retina versus the nonspecific activation of multiple cell types arising from artificial stimulation. To replicate these natural signaling patterns, stimulation strategies must be capable of preferentially activating specific retinal ganglion cell (RGC) types. To design more selective stimulation strategies, a better understanding of the morphological factors that underlie the sensitivity to prosthetic stimulation must be developed. Herein, the role that different anatomical components play in driving the direct activation of RGCs by extracellular stimulation is focused on. Briefly, 1) the variability in morphological properties of α‐RGCs is characterized, 2) the influence of morphology on the direct activation of RGCs by electric stimulation is detailed, and 3) some of the potential biophysical mechanisms that could explain differences in activation thresholds and electrically evoked responses between RGC types are described.

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Y-Cell Receptive Field and Collicular Projection of Parasol Ganglion Cells in Macaque Monkey Retina

Cited by 132 publications

References 91 publications

Variability of Visual Responses of Superior Colliculus Neurons Depends on Stimulus Velocity

Variability of Visual Responses of Superior Colliculus Neurons Depends on Stimulus Velocity

The Primate Retina Contains Distinct Types of Y-Like Ganglion Cells: Figure 1.

Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina

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