Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control

Mordovkina, Daria A.; Lyabin, Dmitry N.; Smolin, Egor A.; Sogorina, Ekaterina M.; Ovchinnikov, Lev P.; Eliseeva, Irina A.

doi:10.3390/biom10040591

Cited by 91 publications

(81 citation statements)

References 212 publications

(321 reference statements)

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“…Y-box (YB) proteins are DNA/RNA-binding proteins that belong to a large family of proteins with an evolutionarily conserved cold-shock domain. These proteins are involved in a number of cellular processes, including proliferation, differentiation, and stress response (Mordovkina et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status

et al. 2020

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“…HNRNPA1 and MBNL1, which belong to the subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs), regulate pre-mRNA processing and other aspects of mRNA metabolism and transport (41). YBX1 has been implicated in the regulation of transcription and translation, pre-mRNA splicing, DNA repair, and mRNA packaging (42).…”

Section: Discussionmentioning

confidence: 99%

Tumor Cell–Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA

Geng

Chen

et al. 2020

Cancer Immunology Research

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Dysfunction in T-cell antitumor activity contributes to the tumorigenesis, progression, and poor outcome of clear cell renal cell carcinoma (ccRCC), with this dysfunction resulting from high expression of programmed cell death-1 (PD-1) in T cells. However, the molecular mechanisms maintaining high PD-1 expression in T cells have not been fully investigated in ccRCC. Here, we describe a mechanism underlying the regulation of PD-1 at the mRNA level and demonstrated its impact on T-cell dysfunction. Transcriptomic analysis identified a correlation between transforming growth factor beta 1 (TGFB1) and PDCD1 in ccRCC samples. The mechanism underlying the regulation of PD-1 mRNA was then investigated in vitro and in vivo using syngeneic tumor models. We also observed that TGFβ1 had prognostic significance in ccRCC patients, and its expression was associated with PD-1 mRNA expression. CcRCC-derived TGFβ1 activated P38 and induced the phosphorylation of Ser 10 on H3, which recruited p65 to increase SRSF3 and SRSF5 expression in T cells. As a result, the half-life of PD-1 mRNA in T cells was prolonged. SRSF3 coordinated with NXF1 to induce PD-1 mRNA extranuclear transport in T cells. We then demonstrated that TGFβ1 could induce SRSF3 expression to restrict the antitumor activity of T cells, which influenced immunotherapy outcomes in ccRCC mouse models. Our findings highlight that tumor-derived TGFβ1 mediates immune evasion and has potential as a prognostic biomarker and therapeutic target in ccRCC.

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“…In all three members of the family, CSDs show more than 90% identity, while CTDs are close in amino acid composition and distribution of charged clusters. CTDs of YB protein family members from different vertebrates show high homology (approximately 60% identity) [ 27 ]. The CSD enables Y-box proteins to interact with both DNA and RNA to control the transcription and translation of specific genes [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma

et al. 2020

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As the most common neoplasm in digestive system, hepatocellular carcinoma (HCC) is one of the most important leading cause of cancer death worldwide. Its high-frequency metastasis and relapse rate lead to the poor survival of HCC patients. However, the mechanism of HCC metastasis is still unclear. Alternative splicing events (ASEs) have a great effect in cancer development, progression and metastasis. We downloaded RNA sequencing and seven types of ASEs data of HCC samples, in order to explore the mechanism of ASEs underlying tumorigenesis and metastasis of HCC. The data was taken from the TCGA and TCGASpliceSeq databases. Univariate Cox regression analysis was used to determine a total of 3197 survival-related ASEs (OS-SEs). And based on 5 OS-SEs screened by Lasso regression, we constructed a prediction model with the Area Under Curve of 0.765. With a good reliability of the model, the risk score was also proved to be an independent predictor. Among identified 390 candidate SFs, Y-box protein 3 (YBX3) was significantly correlated with OS and metastasis. Among 177 ASEs, ABCA6-43162-AT and PLIN5-46808-AT were identified both associated with OS, bone metastasis and co-expressed with SFs. Then we identified primary bile acid biosynthesis as survival related KEGG pathway by GSVA and univariate regression analysis, which was correlated with ABCA6-43162-AT and PLIN5-46808-AT. Finally, we proposed that ABCA6-43162-AT and PLIN5-46808-AT may contribute to HCC poor prognosis and metastasis under the regulation of aberrant YBX3 through the pathway of primary bile acid biosynthesis.

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Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control

Cited by 91 publications

References 212 publications

Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status

Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status

Tumor Cell–Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA

Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma

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