Y-Box-binding protein-1 is a promising predictive marker of radioresistance and chemoradioresistance in nasopharyngeal cancer

Tay, Wei-Lin; Yip, George; Tan, Puay‐Hoon; Matsumoto, Ken; Yeo, Reuben J.; Ng, Tze‐Pin; Kumar, Srinivasan Dinesh; Tsujimoto, Masafumi; Bay, Boon‐Huat

doi:10.1038/modpathol.2008.181

Cited by 39 publications

(26 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was reported that the expression of YB-1 increases in cancer cells and its high expression or expression in nucleus were associated with poor prognosis in many types of cancer [6–9, 13]. Also, this nuclear expression of YB-1 in tumor cell activates gene transcription for protein and relates to multidrug resistance and ionizing radiation [10, 14]. …”

Section: Discussionmentioning

confidence: 99%

The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean

et al. 2015

View full text Add to dashboard Cite

BackgroundThe human Y-box-binding protein 1 (YB-1) is a member of the DNA/RNA-binding family of proteins that regulates transcription and translation of genes. Previous studies suggest that YB-1 may have an oncogenic role in various cancers. In this study, we evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer.MethodsImmunohistochemical staining study was performed with YB-1 using tissue block from 233 patients with invasive ductal carcinoma. Patients were divided into two groups according to expression of cytoplasmic YB-1 in tumor cell (high versus low). The relationship between the expression of YB-1, clinicopathological characteristics and breast cancer prognosis was analyzed.ResultsHormone receptor negativity, worse histologic and nuclear grade, high tumor stage, lymphovascular invasion and high Ki67 (≥14 %) were related with the increased expression of cytoplasmic YB-1 in tumor cell (p < 0.05). Although there was no significant difference in relapse-free survival (RFS) between the two groups (p = 0.412), difference in overall survival (OS) was statistically significant (p = 0.035). In multivariate analysis for OS, YB-1 was an independent prognostic factor (p = 0.043).ConclusionThis suggests that the increased expression of cytoplasmic YB-1 in tumor cells can be regarded as an independent prognostic factor for breast cancer, related to poor prognostics. Expression of cytoplasmic YB-1 in cancer cell could be used as an independent prognostic marker for predicting OS in breast cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean

et al. 2015

View full text Add to dashboard Cite

show abstract

“…vRNP was prepared from purified influenza A/Puerto Rico/8/34 (A/PR/8/34) virus as previously described (66). Rabbit polyclonal antibodies against YB-1, RAP55, RCK, PB1, PB2, PA, M1, and NP and rat antibody against NS2 were prepared as previously described (30,31,40,50,71,72,77). Rabbit polyclonal antibodies against TIAR, PML (Santa Cruz Biotechnology), and Rab11a (Invitrogen) and mouse monoclonal antibodies against ␣-tubulin (Sigma) and PML (Santa Cruz Biotechnology) were purchased.…”

Section: Methodsmentioning

confidence: 99%

YB-1 Functions as a Porter To Lead Influenza Virus Ribonucleoprotein Complexes to Microtubules

Kawaguchi

Matsumoto

Nagata

2012

J Virol

Self Cite

View full text Add to dashboard Cite

-1), a cellular protein that is involved in regulation of cellular transcription and translation. YB-1 translocated to the nucleus from the cytoplasm and accumulated in PML nuclear bodies in response to influenza virus infection. vRNP assembled into the exporting complexes with YB-1 at PML nuclear bodies. After nuclear export, using YB-1 knockdown cells and in vitro reconstituted systems, YB-1 was shown to be required for the interaction of vRNP exported from the nucleus with microtubules around the microtubule-organizing center (MTOC), where Rab11a-positive recycling endosomes were located. Further, we also found that YB-1 overexpression stimulates the production of progeny virions in an Rab11a-dependent manner. Taking these findings together, we propose that YB-1 is a porter that leads vRNP to microtubules from the nucleus and puts it into the vesicular trafficking system.

show abstract

“…However, it is unclear whether these molecules continue to be relevant as prognostic factors for patients with DLBCL who are treated with rituximab plus CHOP/CHOP-like chemotherapy. Meanwhile, in some reports, the expression of YB-1 in tumor tissues has been shown to be restricted to the cytoplasm [12,24], and no correlation has been found between the expressions of YB-1 and P-gp [20]. The role of YB-1 in predicting the outcome of malignant neoplasms is thus still unclear.…”

Section: Introductionmentioning

confidence: 92%

Y-box binding protein-1 expression in diffuse large B-cell lymphoma: an impact on prognosis in the rituximab era

Momose¹,

Higashi²,

Tokuhira³

et al. 2010

Leukemia & Lymphoma

View full text Add to dashboard Cite

The expression of YB-1 has been reported to predict poor clinical outcome in many human malignancies, including hematopoietic malignancies. In this study, we investigated the correlations between YB-1 expression and the clinicopathological features of patients with diffuse large B-cell lymphoma (DLBCL) in a single institution. The expression of YB-1 was analyzed in 168 cases by immunohistochemistry. Fifteen out of 168 cases (8.9%) showed cytoplasmic expression of YB-1. The expression of YB-1 was significantly associated with 5-year overall survival (OS) (p = 0.023). Rituximab plus CHOP therapy (n = 94) improved the 5-year survival rate in both YB-1-positive and -negative patients. In conclusion, the data presented in this report provide evidence that the cytoplasmic expression of YB-1 is a poor prognosis factor in DLBCL treated with CHOP therapy, whereas rituximab improves the survival of both YB-1-positive and -negative patients with DLBCL.

show abstract

Y-Box-binding protein-1 is a promising predictive marker of radioresistance and chemoradioresistance in nasopharyngeal cancer

Cited by 39 publications

References 34 publications

The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean

The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean

YB-1 Functions as a Porter To Lead Influenza Virus Ribonucleoprotein Complexes to Microtubules

Y-box binding protein-1 expression in diffuse large B-cell lymphoma: an impact on prognosis in the rituximab era

Contact Info

Product

Resources

About