Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships

Ajovalasit, Augusto; Sabatino, Maria Antonietta; Todaro, Simona; Alessi, Sabina; Giacomazza, Daniela; Picone, Pasquale; Carlo, Marta Di; Dispenza, Clelia

doi:10.1016/j.carbpol.2017.09.092

Cited by 73 publications

(32 citation statements)

References 25 publications

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“…The transition temperature of xyloglucans is inversely proportional to the concentration of polymer and the percentage of galactose residues removed [48,49]. Xyloglycans undergo a phase transition at a much lower concentration (1 to 3% wt) compared to other thermo-sensitive polymers, including block polymers [50,51]. Xyloglucans are highly biocompatible, biodegradable, and have high water absorption/retention capacity.…”

Section: Xyloglucanmentioning

confidence: 99%

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Thermosensitive Hydrogels–a Potential Carrier for the Delivery of Drugs and Macromolecules

et al. 2021

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In this review, the authors have discussed scientific advances in thermosensitive hydrogels over the past two decades. The ability of the thermo-sensitive hydrogel to undergo rapid changes with response to temperature makes it an attractive candidate for many biomedical applications such as targeted drug delivery, wound healing, soft contact lenses, sensors, tissue regeneration, gene, and protein delivery. This review aims to deliver a brief overview of gelation properties, merits, and demerits of various natural and synthetic thermo-sensitive polymers that have significant clinical relevance. The report emphasizes the importance of injectable thermosensitive hydrogels, as it can offer improved solubility of hydrophobic drugs and site-specificity, extended-release of drugs and macromolecules, improved safety, and local administration of drugs. The authors has also provided a commentary on the delivery of drugs or macromolecules from thermo-sensitive hydrogels through various approaches. This review highlights the current status of research in thermo-sensitive hydrogels and emphasizes the importance of developing nontoxic thermo-sensitive hydrogels, dual responsive, and multi-responsive hydrogel systems.

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Section: Xyloglucanmentioning

confidence: 99%

“…Derivatized xyloglucans are interconnected three-dimensional microporous systems that adhere to cells and detach when the suitable temperature is reached. The microporous structure of xyloglucans directs them to be a potential delivery vehicle in the use of regenerative medication [51,57].…”

Section: Xyloglucanmentioning

confidence: 99%

Thermosensitive Hydrogels–a Potential Carrier for the Delivery of Drugs and Macromolecules

et al. 2021

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“…In our last work [1] we showed that composite materials from cotton fabric and polylactic acid suggested having improved properties such as antibiotic delivery, mechanical strength, and an enhanced healing process while preventing bacterial infection. The reviewed literature shows that cotton fabric coated with different materials such as hydrocolloids [7], hydrogels [8,9], chitosan [7,10], or silver nanoparticles [5] displays an improved wound dressing property. Proper combinations of biodegradable materials that could quick-release antibiotics at the beginning then slow and controlled release with time, would make excellent material for wound care management.…”

Section: Introductionmentioning

confidence: 99%

Novel slow drug release bioceramic composite materials for wound dressing applications: potential of natural materials

Macha

Sultan

2020

SN Appl. Sci.

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There is a need for friendly and affordable wound dressing materials capable of uptaking and releasing active clinical agents. Proper combinations of materials that could quickly release antibiotics at the beginning, then slow and controlled release with time would make excellent materials for wound care management. In this study, cotton handwoven fabric hydroxyapatite (derived from coralline skeletons) polylactic acid composites were developed. The developed composites were characterized in terms of their physical and mechanical properties. Also, the in vitro drug release profiles for the developed composites were established. Bacteria efficacy of natural antimicrobial agents loaded composites against gram-positive bacteria Staphylococcus aureus (S. aureus) was also studied. The results suggested that the hand-weaving method has the potential to control the porosity of the fabric for different applications. Woven fabric with 1 mm pore sizes is suggested to have better particle uptake properties and moderate mechanical and physical properties suitable for wound dressing applications. Particle embedment capacity (w/w %) seemed to increase as the fabric pore sizes increases. On the other hand fabric with 1 mm pore sizes uptakes the highest amount of particles (0.174 g). A combination of coralline derived hydroxyapatite particles with cotton fabric suggested controlling the drug release rate by 30% compared with the fabric without the particles, appropriate for prolonged drug release applications. The released drug and natural antimicrobial agents from the developed composites suggested inhibiting microbial growth in which honey performed close to a clinical antibiotic. It was recommended to conduct an in vivo study for the developed composite.

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“…[17][18][19] Although a lot of gel formulations related to Xyl have been reported before, there are not so many studies for the application of Xyl sheets to wound healing. 13,14,[20][21][22][23][24][25][26][27][28][29][30][31] For Xyl-sugar hydrogel sheets, promotion of wound healing by sugar and maintenance of appropriate moisture are expected.…”

Section: Introductionmentioning

confidence: 99%

Novel Xyloglucan Sheet for the Treatment of Deep Wounds: Preparation, Physicochemical Characteristics, and <i>in Vivo</i> Healing Effects

Hirose

Sasatsu

Toraishi

et al. 2019

Biological & Pharmaceutical Bulletin

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In the present study, a novel wound dressing made of xyloglucan (Xyl)-sucrose (Suc) hydrogel was developed for the treatment of deep wounds including pressure ulcers. The dressing was prepared by casing an aqueous solution of Xyl and sugar and then warming, and a hydrogel sheet was obtained. The in vitro characteristics of these sheets, such as their strength, extensibility, water content, adhesion potential, and water absorption, were examined. The strength, Young's modulus, and adhesion strength of the sheets were greater when they had a lower water content. Furthermore, adhesion and gradual water absorbability were similar to those of commercial dressings. These in vitro features suggest that Xyl sheets possess the physicochemical properties required for wound dressings. In the in vivo experiment, a Xyl sheet made from a mixture of 3.0% (w/v) Xyl solution and 33.3% (w/w) Suc, which displayed moderate strength and water content, was selected and compared with gauze, commercial polyurethane film, and Xyl/Suc (1 : 2) hydrogel using a rat deep wound model caused by serious frostbite. Wound healing rates based on reductions in wound areas were the best in the order of the sheet > hydrogel > commercial film > gauze. The sheet resulted in better wound surface states than the other preparations by improving the conditions. Thus, the potential applicability of Xyl sheets to the treatment of deep wounds was demonstrated.

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Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships

Cited by 73 publications

References 25 publications

Thermosensitive Hydrogels–a Potential Carrier for the Delivery of Drugs and Macromolecules

Thermosensitive Hydrogels–a Potential Carrier for the Delivery of Drugs and Macromolecules

Novel slow drug release bioceramic composite materials for wound dressing applications: potential of natural materials

Novel Xyloglucan Sheet for the Treatment of Deep Wounds: Preparation, Physicochemical Characteristics, and <i>in Vivo</i> Healing Effects

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