Xylitol Toxicosis in Dogs

Retrospective evaluation of acute liver failure in dogs (1995–2012): 49 cases

“…Only 7/49 (14%) of the dogs survived to discharge. This survival rate is in accordance with that suggested in isolated case reports in dogs with toxic or infectious causes of ALF (0–37%), and is similar to the survival rate (10–30%) reported for ALF in people in the absence of transplantion …”

“…In the veterinary literature, isolated case series of dogs with acute hepatic disease related to toxins, drugs, neoplasia, or infection have been reported . Although these reports include dogs that fit the criteria for ALF, no comprehensive study reporting solely on dogs with ALF exists.…”

Wulingsan (Oryeongsan/Goreisan) ameliorate lipid metabolism of obesity rats via regulation of the plasma metabolic profiling

“…Citrulline is an important nutritional supplement to help balance nitrogen and metabolism in the body, whereas a previous study showed that increased plasma citrulline in obesity mice may predict the development of the metabolic syndrome . Although the visceral fat volume, plasma insulin and lipid concentrations of the xylitol‐fed rats were lower than those of the high‐fat diet rats , excessive xylitol could also lead to obesity and elevated blood lipids . Both of the two metabolites were normalized after oral administration of WLS.…”

Retrospective evaluation of the use of glucagon infusion as adjunctive therapy for hypoglycemia in dogs: 9 cases (2005–2014)

“…Many conditions may result in hypoglycemia in small animals. These include iatrogenic insulin overdose, insulinoma, xylitol toxicosis, hypoadrenocorticism, sepsis, and paraneoplastic disease . Two of the patients in this series were receiving exogenous insulin for previously diagnosed diabetes mellitus; 1 was then diagnosed with hypoadrenocorticism and 1 with an insulinoma.…”