Xylitol Production by an<i>Enterobacter</i>Species

Yoshitake, Juichi; Ishizaki, Haruki; Shimamura, Mutsuo; Imai, Tomio

doi:10.1080/00021369.1973.10861002

Cited by 30 publications

(4 citation statements)

References 1 publication

(1 reference statement)

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“…Although "pathway B" predominates in fungi, e.g., Aspergillus niger [15], yeast, e.g., Candida guilliermondii [16], Pichia spitis [17], Pichia caribbica [18] and Scheffersomyces amazonensis [19], and dairy yeast, e.g., Kluyveromyces marxianus [20], but few bacteria, e.g., Enterobacter sp. [21], Corynebacterium, Enterobacter [22], Bacillus and Pseudomonas [23], were also reported for xylitol production (Table 3). Around 960 wild yeast strains were isolated from soil, wood and insect larvae and termites and compared for xylose consumption.…”

Section: Third Generation (Microbial Fermentation and Enzymatic Transmentioning

confidence: 98%

Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Ahuja

Macho

Ewe

et al. 2020

Foods

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Xylitol is a white crystalline, amorphous sugar alcohol and low-calorie sweetener. Xylitol prevents demineralization of teeth and bones, otitis media infection, respiratory tract infections, inflammation and cancer progression. NADPH generated in xylitol metabolism aid in the treatment of glucose-6-phosphate deficiency-associated hemolytic anemia. Moreover, it has a negligible effect on blood glucose and plasma insulin levels due to its unique metabolism. Its diverse applications in pharmaceuticals, cosmetics, food and polymer industries fueled its market growth and made it one of the top 12 bio-products. Recently, xylitol has also been used as a drug carrier due to its high permeability and non-toxic nature. However, it become a challenge to fulfil the rapidly increasing market demand of xylitol. Xylitol is present in fruit and vegetables, but at very low concentrations, which is not adequate to satisfy the consumer demand. With the passage of time, other methods including chemical catalysis, microbial and enzymatic biotransformation, have also been developed for its large-scale production. Nevertheless, large scale production still suffers from high cost of production. In this review, we summarize some alternative approaches and recent advancements that significantly improve the yield and lower the cost of production.

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Section: Third Generation (Microbial Fermentation and Enzymatic Transmentioning

confidence: 98%

Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Ahuja

Macho

Ewe

et al. 2020

Foods

View full text Add to dashboard Cite

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“…XR (Figure 1) enzymatic activity is present in Enterobacter liquefaciens, with NADPH as co-factor, and a productivity of 0.35 g L −1 h −1 has been reported in this case [110]. The XR route has also evolved in enteric bacteria such as E. coli; however, the efficiency of the pathway is low.…”

Section: Xylitolmentioning

confidence: 79%

“…Thus, there is a need to look for other microorganisms capable of producing xylitol with high yields, namely bacterial species. Several studies have shown the ability of some bacterial strains, namely Cellulomonas, Corynebacterium sp., Enterobacter liquefaciens, Gluconobacter oxydans, Mycobacterium smegmatis, and Serratia, to produce xylitol [106][107][108][109][110].…”

Section: Xylitolmentioning

confidence: 99%

Xylose Metabolism in Bacteria—Opportunities and Challenges towards Efficient Lignocellulosic Biomass-Based Biorefineries

et al. 2021

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In a sustainable society based on circular economy, the use of waste lignocellulosic biomass (LB) as feedstock for biorefineries is a promising solution, since LB is the world’s most abundant renewable and non-edible raw material. LB is available as a by-product from agricultural and forestry processes, and its main components are cellulose, hemicellulose, and lignin. Following suitable physical, enzymatic, and chemical steps, the different fractions can be processed and/or converted to value-added products such as fuels and biochemicals used in several branches of industry through the implementation of the biorefinery concept. Upon hydrolysis, the carbohydrate-rich fraction may comprise several simple sugars (e.g., glucose, xylose, arabinose, and mannose) that can then be fed to fermentation units. Unlike pentoses, glucose and other hexoses are readily processed by microorganisms. Some wild-type and genetically modified bacteria can metabolize xylose through three different main pathways of metabolism: xylose isomerase pathway, oxidoreductase pathway, and non-phosphorylative pathway (including Weimberg and Dahms pathways). Two of the commercially interesting intermediates of these pathways are xylitol and xylonic acid, which can accumulate in the medium either through manipulation of the culture conditions or through genetic modification of the bacteria. This paper provides a state-of-the art perspective regarding the current knowledge on xylose transport and metabolism in bacteria as well as envisaged strategies to further increase xylose conversion into valuable products.

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“…Therefore, the production of xylitol via microorganisms, which can be performed under mild conditions is expected to meet market demands with a more economic value [ 17 ]. Various microorganisms, such as bacteria, yeast, and fungi, were studied for their ability to convert xylose to xylitol [ 16 , 18 , 19 , 20 ]. Among these microorganisms, Debaryomyces hansenii is one of the best yeasts for generating xylitol in high concentrations [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

An Integrated Process for the Xylitol and Ethanol Production from Oil Palm Empty Fruit Bunch (OPEFB) Using Debaryomyces hansenii and Saccharomyces cerevisiae

et al. 2022

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Oil palm empty fruit bunch (OPEFB) is the largest biomass waste from the palm oil industry. The OPEFB has a lignocellulose content of 34.77% cellulose, 22.55% hemicellulose, and 10.58% lignin. Therefore, this material’s hemicellulose and cellulose content have a high potential for xylitol and ethanol production, respectively. This study investigated the integrated microaerobic xylitol production by Debaryomyces hansenii and anaerobic ethanol semi simultaneous saccharification and fermentation (semi-SSF) by Saccharomyces cerevisiae using the same OPEFB material. A maximum xylitol concentration of 2.86 g/L was obtained with a yield of 0.297 g/gxylose. After 96 h of anaerobic fermentation, the maximum ethanol concentration was 6.48 g/L, corresponding to 71.38% of the theoretical ethanol yield. Significant morphological changes occurred in the OPEFB after hydrolysis and xylitol and ethanol fermentation were shown from SEM analysis.

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Xylitol Production by anEnterobacterSpecies

Cited by 30 publications

References 1 publication

Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Xylose Metabolism in Bacteria—Opportunities and Challenges towards Efficient Lignocellulosic Biomass-Based Biorefineries

An Integrated Process for the Xylitol and Ethanol Production from Oil Palm Empty Fruit Bunch (OPEFB) Using Debaryomyces hansenii and Saccharomyces cerevisiae

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