Xy Spermatocytes in an Xyy Male

Evans, E. P.; Ford, C. E.; Chaganti, R. S. K.; Blank, C. E.; Hunter, Henry

doi:10.1016/s0140-6736(70)90949-9

Cited by 47 publications

(21 citation statements)

References 7 publications

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“…Analysis of the sex chromosome complements of sperm from XYY men has confirmed the rarity of sex chromosomally aneuploid gametes (Benet and Martin, 1988;Blanco et al, 1997;Chevret et al, 1997). The fertility of XYY men is explained by the fact that they are usually germinal XY/XYY mosaics (Thompson et al, 1967;Melynk et al, 1969;Evans et al, 1970;Hultén, 1970;Chandley et al, 1976;Faed et al, 1976;Speed et al, 1991;Gabriel-Robez et al, 1996). Nevertheless, it is clear from histological assessment of the testes of XYY men that some degree of spermatogenic impairment is common, and in some men it is severe (Hultén, 1970;Skakkebaek et al, 1973;Baghdassarian et al, 1975;Solari and Valzacchi, 1997); the low incidence of XYY men in fertility clinics could be due to a reduced frequency of marriage.…”

Section: Discussionmentioning

confidence: 95%

Evidence that sex chromosome asynapsis, rather than excess Y gene dosage, is responsible for the meiotic impairment of XYY mice

Rodríguez

Burgoyne²

2000

Cytogenet Genome Res

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There is extensive evidence for the existence of a meiotic checkpoint that acts to eliminate spermatocytes that fail to achieve full sex chromosome synapsis at the pachytene stage of the first meiotic prophase. XYY mice are nearly always sterile, with clear signs of meiotic impairment, and sex chromosome asynapsis has been proposed to underlie this impairment. However, a study of XYY*^X mice (mice having three sex chromosomes but only a single dose of Y genes) revealed that these mice are fertile, and thus implicated Y gene dosage as a major factor in the sterility of XYY mice. To address this question further, sex chromosome synapsis and spermatogenic proficiency were compared between XYY*^X and XYY mice generated in the same litters. This established that differences in spermatogenic proficiency within and between the two genotypes correlated with the frequency of radial trivalent formation (full sex chromosome synapsis); XYY*^X males, as a group, had double the radial trivalent frequency of XYY males. This observation provides strong support for the view that sex chromosome asynapsis (or some consequence thereof), rather than Y gene dosage, is the major factor leading to the meiotic impairment of XYY mice.

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Section: Discussionmentioning

confidence: 95%

Evidence that sex chromosome asynapsis, rather than excess Y gene dosage, is responsible for the meiotic impairment of XYY mice

Rodríguez

Burgoyne²

2000

Cytogenet Genome Res

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“…Thus our finding supports the view of Evans et al (1978) that the mouse system in this regard differs from the human one (Melnyk ct al. 1969;Evans et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

A 39,X/40,XY/41,XYY mosaic male mouse

Ak²

1984

Cytogenet Genome Res

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Cytogenetic analyses of bone marrow and gonadal cells in a male mouse, which appeared to be normal, revealed mosaicism in both tissues. Three chromosome complements, 39, X, 40, XY, and 41, XYY, were found in both bone marrow and spermatogonia, while only the last two complements were found in spermatocytes. In this mouse, unlike in the human, the XYY cells showed a proliferative advantage over the XY cells. In XYY cells at diakinesis/metaphase I the gonosomes showed all possible types of association, and a pairing advantage of the X chromosome was clearly demonstrated. The fertility of the mouse was not determined. However, since the epididymal sperm count was reduced by only 55% and the incidence of sperm head abnormality was near normal, it is not evident that the mouse was sterile.

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“…and 1 case had oligozoospermia. The extra Y chromosome in XYY men is eliminated during spermatogenesis [14], Speed et al [ 15] reported that XYY cells reached meta phase I. Han et al [16] found that the overall ratio of X-to Y-bearing sperm did not differ from that of normal donors using double FISH with X and Y chromosome probes.…”

Section: Xyymentioning

confidence: 99%

Cytogenetic Survey of 1,007 Infertile Males

Yoshida

Miura

Shirai³

1997

Urol Int

100

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The aim of this study was to investigate the influence of a chromosome abnormality on male infertility. The subjects consisted of 1,007 males with the chief complaint of infertility. Karyotyping was conducted mainly by G banding. Major chromosome abnormalities were observed in 62 patients (6.2%) in total and consisted of sex chromosome abnormalities in 38 patients (3.8%) and autosomal chromosome abnormalities in 24 (2.4%). Among the patients with sex chromosome abnormalities, 28 cases were 47, XXY, 3 were 47, XYY, and 7 cases had a Y chromosome abnormality. Autosomal chromosome abnormalities comprised 10 cases of reciprocal translocation, 8 cases of Robertsonian translocation, 5 cases of inversion, and 1 case of ring chromosome. In patients with a sperm density < 5 × 10⁶/ml, a total motile sperm count < 1 × 10⁶, a follicle-stimulating hormone value = 30.1 mlU/ml, a luteinizing hormone value = 8.9 mlU/ml, a testosterone value ≤ 2.69 ng/ml, or an average testis volume ≤ 8 ml, the incidence of major chromosome abnormalities was significantly higher. These findings suggest that patients who need microinsemination should undergo chromosome analysis. We should counsel patients about obtaining adequate information on each chromosome abnormality.

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Xy Spermatocytes in an Xyy Male

Cited by 47 publications

References 7 publications

Evidence that sex chromosome asynapsis, rather than excess Y gene dosage, is responsible for the meiotic impairment of XYY mice

Evidence that sex chromosome asynapsis, rather than excess Y gene dosage, is responsible for the meiotic impairment of XYY mice

A 39,X/40,XY/41,XYY mosaic male mouse

Cytogenetic Survey of 1,007 Infertile Males

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