XY gonadal dysgenesis in a heifer

Sharma, AK; Vijaykumar, N; Khar, S. K.; Verma, SK; Nigam, J. M.

doi:10.1136/vr.107.14.328

Cited by 13 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the mid 1960's, Henricson and Akesson [1967] described 2 cases of XY sex reversal, these animals represent the first male-to-female sex-reversed cattle to be reported. Following this first article several other reports appeared [Chapman et al, 1978;Sharma et al, 1980;Murakami et al, 1989;Kondoh et al, 1992;Hare et al, 1994]. In the article by Murakami and colleagues, a Holstein heifer with a 60,XY karyotype and female characteristics is described: ovaries (but no histological examinations were performed), uterus and vagina; moreover, a feeble oestrus was reported.…”

Section: Gonadal Differentiation Abnormalitiesmentioning

confidence: 98%

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

Villagómez

Parma

Radi

et al. 2009

Cytogenet Genome Res

View full text Add to dashboard Cite

The association of abnormal chromosome constitutions and disorders of sex development in domestic animals has been recorded since the beginnings of conventional cytogenetic analysis. Deviated karyotypes consisting of abnormal sex chromosome sets (e.g. aneuploidy) and/or the coexistence of cells with different sex chromosome constitutions (e.g. mosaicism or chimerism) in an individual seem to be the main causes of anomalies of sex determination and sex differentiation. Molecular cytogenetics and genetics have increased our understanding of these pathologies, where human and mouse models have provided a substantial amount of knowledge, leading to the discovery of a number of genes implicated in mammalian sex determination and differentiation. Additionally, other genes, which appeared to be involved in ovary differentiation, have been found by investigations in domestic species such as the goat. In this paper, we present an overview of the biology of mammalian sex development as a scientific background for better understanding the body of knowledge of the clinical cytogenetics of disorders of sex development in domestic animals. An attempt to summarize of what has been described in that particular subject of veterinary medicine for each of the main mammalian domestic species is presented here.

show abstract

Section: Gonadal Differentiation Abnormalitiesmentioning

confidence: 98%

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

Villagómez

Parma

Radi

et al. 2009

Cytogenet Genome Res

View full text Add to dashboard Cite

show abstract

“…It has been reported in a variety of animals including sheep, goats and cows (Sharma et al. ; Smith et al. , ; Timurkaan and Ozer ; Raggio et al.…”

Section: Introductionmentioning

confidence: 97%

A Case of Successful Pregnancy in a Ewe with Uterus Didelphys

Carr

Aitken

Milne

et al. 2013

Reprod Domestic Animals

View full text Add to dashboard Cite

Uterus didelphys is a rare congenital abnormality of the reproductive tract. Although it occurs in various species, there are no published reports describing pregnancy outcome in association with this abnormality. Herein we describe a case of successful unilateral singleton pregnancy in a ewe incidentally found to have uterus didelphys during the course of a biomedical research study. The pregnancy was established using assisted reproductive techniques and interrupted in late gestation, at which point the abnormality was identified. Serial ultrasound assessment of foetal biometry revealed a normal foetal growth trajectory. Despite a 45% reduction in placentome number, total placentome weight was near normal secondary to compensatory placentome growth and development. To our knowledge, this is the first detailed report of normal foetal growth in an animal with uterus didelphys and illustrates the ability of the ovine placenta to adapt to a reduced number of placentomes and maintain foetal nutrient supply.

show abstract

“…Bovine XY sex reversal syndrome has been found to be much more common than its counterpart (XX sex reversal syndrome). Indeed, several cases have been reported in this species [Henricson and Akesson, 1967;Chapman et al, 1978;Sharma et al, 1980;Murakami et al, 1989;Kondoh et al, 1992;Hare et al, 1994]. Later, when SRY sequences were published [Payen and Cotinot, 1994], testing XY sex reversal animals for the SRY gene revealed the lack of SRY sequences by both PCR and FISH-mapping analysis in such individuals [Kawakura et al, 1996[Kawakura et al, , 1997.…”

Section: Sex Reversal Syndromementioning

confidence: 99%

Disorders of Sexual Development and Abnormal Early Development in Domestic Food-Producing Mammals: The Role of Chromosome Abnormalities, Environment and Stress Factors

Favetta

Villagómez

Iannuzzi

et al. 2011

Sex Dev

View full text Add to dashboard Cite

The management of disorders of sexual development (DSD) in humans and domestic animals has been the subject of intense interest for decades. The association between abnormal chromosome constitutions and DSDs in domestic animals has been recorded since the beginnings of conventional cytogenetic analysis. Deviated karyotypes consisting of abnormal sex chromosome sets and/or the coexistence of cells with different sex chromosome constitutions in an individual seem to be the main causes of anomalies of sex determination and sex differentiation. In recent years, a growing interest has developed around the environmental insults, such as endocrine-disrupting compounds (EDC) and heat stressors, which affect fertility, early embryonic development and, in some instances, directly the sex ratio and/or the development of 1 specific sex versus the other. A variety of chemical compounds present in the environment at low doses has been shown to have major effects on the reproductive functions in human and domestic animals following prolonged exposure. In this review, we present an overview of congenital/chromosomal factors that are responsible for the DSDs and link them and the lack of proper embryonic development to environmental factors that are becoming a major global concern.

show abstract

XY gonadal dysgenesis in a heifer

Cited by 13 publications

References 0 publications

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

A Case of Successful Pregnancy in a Ewe with Uterus Didelphys

Disorders of Sexual Development and Abnormal Early Development in Domestic Food-Producing Mammals: The Role of Chromosome Abnormalities, Environment and Stress Factors

Contact Info

Product

Resources

About