Xurography and Lamination for Manufacturing Point-of-Care (POC) Micromixers

Rapid Fabrication of Disposable Micromixing Arrays Using Xurography and Laser Ablation

“…Standard commercial Arlon vinyl sheets (polyvinyl chloride; Arlon Graphics, Placentia, CA, USA) were used for the manufacturability assessment (this vendor was selected considering the availability of a worldwide distributor network). Manufacture using xurography was employed on a testing material with three color variations; gray (G X ), orange (O X ), and black (B X ) using a similar methodology introduced by a previous work for a single micromixer device [ 10 , 45 ] and then adapted and employed on materials of the same batch for gray (G L ), orange (O L ), and black (B L ) using ablation. The procedures can be summarized as follows: a microfluidic device can be developed by patterning and stacking four layers of materials.…”

“…The implementation of the rapid fabrication methodology studied in this article was assessed in the manufacturing process of a passive micromixing following a procedure presented in previous work [ 10 ] and expanded for an array configuration. The implemented design is based on previous research [ 10 , 40 , 45 ] on an unbalanced split and recombine micromixer. Figure 1 a,b shows our proposed testing device setup.…”

“…To address these restrictions in the deployment of a particular type of microfluidic device (SAR) micromixer, we have recently developed a methodology to produce single devices from scratch to testing without the requirement of ancillary laboratory equipment [ 10 , 45 ]. Combining xurography and lamination offered promissing advantages over conventional manufacture such as flexibility, short cycle times, and low-cost.…”

“…In this work, we present a scaled-up version of a novel split-and-recombine (SAR) array design presented before by our group [ 10 , 45 ] and adapted to be an interface for a handheld multichannel micropipette as a step forward to meet the aforementioned criteria. The manufacturability has been assessed for xurography and laser ablation.…”