Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats

Chen, Yi; Tong, Huasheng; Zhang, Xingqin; Tang, Liang; Pan, Zhiguo; Liu, Zhifeng; Duan, Peng-kai; Su, Lei

doi:10.1016/s0254-6272(13)60133-8

Cited by 28 publications

(38 citation statements)

References 19 publications

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“…A pilot study by our group showed that the formation of heat stroke in the saline-treated rats was 73.6±1.8 min under heat stress (16) similar to the time determined by previous studies (17,18). Therefore, arterial blood (0.5 ml) was drawn from the right femoral artery at 0, 20, 40 and 60 min after the start of the experiment.…”

Section: Methodssupporting

confidence: 85%

Xuebijing injection attenuates pulmonary injury by reducing oxidative stress and proinflammatory damage in rats with heat stroke

Chen

Tong

Pan

et al. 2017

Experimental and Therapeutic Medicine

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The present study aimed to investigate the protective effect of Xuebijing injection (XBJ) on lung injury in heat-stroke rats and the underlying mechanisms. In total, 54 rats were randomly assigned to non-thermal, saline vehicle and XBJ groups. The rectal temperature (Tc), mean arterial pressure (MAP) and respiratory rate (RR) of the rats were recorded. The time-point of heat stroke and the time of survival were assessed, and indicators of arterial blood gas were regularly measured from 0 to 60 min. The concentration of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-10 was also determined. At the end of the experiment, lung tissue was harvested for histopathological analysis. Inducible nitric oxide synthase (iNOS) and superoxide dismutase (SOD) expression was measured by immunohistochemistry. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling was used to measure apoptosis. XBJ pretreatment prolonged the decline of clinical characteristics, as demonstrated by increases in Tc, MAP, RR and indicators in arterial blood gas in rats under heat stress. The time until heat stroke and the survival time in the Saline group were shorter than in rats treated with XBJ. The expression of iNOS in lung tissue and the concentration of TNF-α, IL-1β and IL-10 in the bronchoalveolar lavage fluid of rats treated with saline was higher than in rats with XBJ pre-treatment. Contrarily, SOD expression in rats treated with saline was decreased compared with that in rats treated with XBJ. Moreover, the apoptotic rate in the lung tissues of rats with saline treatment was higher than that in rats treated with XBJ. In conclusion, XBJ delayed the development of heat stroke and increased the survival time in rats under heat-stress by ameliorating pulmonary failure and acute lung injury. The underlying mechanisms of this effect may be the reduction of inflammatory cytokines as well as attenuation of oxidative stress and apoptosis by XBJ.

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Section: Methodssupporting

confidence: 85%

Xuebijing injection attenuates pulmonary injury by reducing oxidative stress and proinflammatory damage in rats with heat stroke

Chen

Tong

Pan

et al. 2017

Experimental and Therapeutic Medicine

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“…Carthami flos , Paeoniae Radix Rubra, Chuanxiong Rhizoma, Salviae miltiorrhizae and Angelicae sinensis Radix are the main constituents of XBJ. XBJ has been widely used in the clinic to treat sepsis and multiple organ dysfunctions [10,11,12]. Recent studies showed that XBJ reduced patient mortality due to sepsis by inhibiting T-cell growth [13].…”

Section: Introductionmentioning

confidence: 99%

Mitigating the Effects of Xuebijing Injection on Hematopoietic Cell Injury Induced by Total Body Irradiation with γ rays by Decreasing Reactive Oxygen Species Levels

Zhang

et al. 2014

IJMS

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Hematopoietic injury is the most common side effect of radiotherapy. However, the methods available for the mitigating of radiation injury remain limited. Xuebijing injection (XBJ) is a traditional Chinese medicine used to treat sepsis in the clinic. In this study, we investigated the effects of XBJ on the survival rate in mice with hematopoietic injury induced by γ ray ionizing radiation (IR). Mice were intraperitoneally injected with XBJ daily for seven days after total body irradiation (TBI). Our results showed that XBJ (0.4 mL/kg) significantly increased 30-day survival rates in mice exposed to 7.5 Gy TBI. This effect may be attributable to improved preservation of white blood cells (WBCs) and hematopoietic cells, given that bone marrow (BM) cells from XBJ-treated mice produced more granulocyte-macrophage colony forming units (CFU-GM) than that in the 2 Gy/TBI group. XBJ also decreased the levels of reactive oxygen species (ROS) by increasing glutathione (GSH) and superoxide dismutase (SOD) levels in serum and attenuated the increased BM cell apoptosis caused by 2 Gy/TBI. In conclusion, these findings suggest that XBJ enhances the survival rate of irradiated mice and attenuates the effects of radiation on hematopoietic injury by decreasing ROS production in BM cells, indicating that XBJ may be a promising therapeutic candidate for reducing hematopoietic radiation injury.

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“…8). XBJ injection is a traditional Chinese medicine preparation and has been widely used clinically for the treatment of sepsis, and it is beneficial to inhibit inflammatory reaction and oxidative stress in China [12]. The main effective components of XBJ are safflower yellow A, tetramethylpyrazine, paeoniflorin, and ferulic acid [9].…”

Section: Discussionmentioning

confidence: 99%

“…XBJ (4 mL/kg) was injected into the test group (intraperitoneal injection), and the control group received saline solution (4 mL/kg, intraperitoneal injection). All the injections were performed twice per day for 7 d [12]. To prevent cannibalism or injury caused by normal socialization, each rat was given a neck collar [13] and housed individually in standard experimental cages in an environmentally controlled room and were fed standard rat chow and water ad libitum.…”

Section: Flap Model and Experimental Designmentioning

confidence: 99%

Beneficial effects of Xuebijing injection on random skin flap survival in rats

Cao

Lin

Cai

et al. 2015

Journal of Surgical Research

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Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats

Abstract: XBJ can alleviate HS-induced systemic inflammatory response syndrome and liver injury in rats, and improve outcomes. These protective effects may be due to the ability of XBJ to inhibit cytokine secretion by KCs.

Cited by 28 publications

References 19 publications

Xuebijing injection attenuates pulmonary injury by reducing oxidative stress and proinflammatory damage in rats with heat stroke

Xuebijing injection attenuates pulmonary injury by reducing oxidative stress and proinflammatory damage in rats with heat stroke

Mitigating the Effects of Xuebijing Injection on Hematopoietic Cell Injury Induced by Total Body Irradiation with γ rays by Decreasing Reactive Oxygen Species Levels

Beneficial effects of Xuebijing injection on random skin flap survival in rats

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