Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway

Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D

“…The high dose of XBJ (18 ml/kg/day) improved the survival of CLP mice ( Figure 1A ). H&E staining was performed to assess the alteration of lung tissues at 24 h after CLP and we graded pathological scores following the established scoring criteria ( Wang Y. et al, 2022 ). The high dose of XBJ treatment dramatically reduced the pathological deterioration caused by CLP, including edema, alveolar collapse, and inflammatory cell infiltration ( Figures 1B,C ).…”

“…The left lobe tissues were used to assess the wet-to-dry weight ratio by the gravimetric method at 24 h after CLP. After the wet lungs were weighed, the lung tissues were dried at 80°C for 48 h. Then, the dry lungs were measured and the ratio between wet and dry lung weights was calculated ( Wang Y. et al, 2022 ).…”

Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway

“…Beside anaphylatoxin, targeting the anaphylotoxin receptors C3aR and C5aR resulted in a prominent anti-inflammatory response in the treatment of COVID-19 ( Carvelli et al, 2020 ; Posch et al, 2021 ). Recent studies have indicated that XFBD inhibited the inflammation of LPS-induced ALI ( Wang et al, 2022b ; Zhao et al, 2021 ). In this study, we found that XFBD significantly reduced histopathological changes and decreased the production of proinflammatory mediators, including IL-6, IL-1β, IL-18, TNF-α and MCP-1 in ALI mice induced by IgG-IC.…”

“…Network pharmacology analysis demonstrated that XFBD play a role in balancing immunity and eliminating the inflammation( Wang et al, 2020b ). Furthermore, studies showed that XFBD prevented the cyclophosphamide-induced immunosuppression( Yan et al, 2021 ) and inhibited the production of cytokine in macrophages( Wang et al, 2022b ). However, the molecular mechanisms of XFBD are still poorly understood.…”

Research and development of Chinese anti-COVID-19 drugs

“…The traditional Chinese medicine prescriptions such as Jinhua qinggan granule 92 , Lianhua Qingwen capsule/granule 93 , Xuebijing injection 94 , Lung Cleaner (Qingfei Paidu decoction) 95 , cure14 (Huashi Baidu granules) 96 , XuanFei Baidu granules 97 , 98 , 99 are collectively termed “three medicines and three formulas”. Besides the above 6 prescriptions, other traditional Chinese medicine prescriptions, such as Fuzheng Huayu tablets 100 , Buzhong Yiqi decoction 101 , Hanshiyi formula 102 , 103 , Reduning injection 104 , 105 , 106 , Tanreqing injection 107 , 108 and FuzhengJiedu granules 109 , 110 , etc.…”