Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway

Wang, Yuying; Sang, Xiaoqing; Shao, Rui; Qin, Honglin; Chen, Xuanhao; Xue, Zhifeng; Li, Lin; Wang, Yu; Zhu, Yan; Chang, Yan‐xu; Gao, Xiumei; Zhang, Boli; Zhang, Han; Yang, Jian

doi:10.1016/j.jep.2021.114701

Cited by 40 publications

(22 citation statements)

References 39 publications

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“…), can directly affect the relevant targets to exert an anti‐inflammatory effect, which is reflected in the reversal of inflammation indicators. On the other hand, as reported in most current studies, 48 , 72 TCM may indirectly inhibit the expression of inflammation related mediators and targets, but the precise mechanism is not yet clear. In short, cell‐based models are the most classic methods currently among the methods for assessing the anti‐inflammatory effects of TCM.…”

Section: The Classical Experimental Model Of the Anti‐inflammatory Ef...mentioning

confidence: 56%

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Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Hou

Guo

et al. 2022

Anim Models and Exp Med

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Inflammation is a common disease involved in the pathogenesis, complications, and sequelae of a large number of related diseases, and therefore considerable research has been directed toward developing anti‐inflammatory drugs for the prevention and treatment of these diseases. Traditional Chinese medicine (TCM) has been used to treat inflammatory and related diseases since ancient times. According to the review of abundant modern scientific researches, it is suggested that TCM exhibit anti‐inflammatory effects at different levels, and via multiple pathways with various targets, and recently a series of in vitro and in vivo anti‐inflammatory models have been developed for anti‐inflammation research in TCM. Currently, the reported classic mechanisms of TCM and experimental models of its anti‐inflammatory effects provide reference points and guidance for further research and development of TCM. Importantly, the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation‐related diseases.

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Section: The Classical Experimental Model Of the Anti‐inflammatory Ef...mentioning

confidence: 56%

“…Eventually, these proinflammatory cytokines work together. As abundant reports show, 48 , 49 TCM (Xuanfei Baidu Decoction and Baitouweng decoction) can exert anti‐inflammatory effects by suppression of IL‐6.…”

Section: The Classic Mechanisms Of the Anti‐inflammatory Effects Of T...mentioning

confidence: 99%

Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Hou

Guo

et al. 2022

Anim Models and Exp Med

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“…A Shimadzu UHPLC system equipped with a photodiode array detector (PDA) was used to qualitatively and quantitatively analyze multiple components in XFBD granule refer to the published article ( Wang et al, 2021 ). Briefly, 2 g of XFBD was extracted with ultrapure water (1:25, g/ml) in an ultrasonic water bath for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Modulating effect of Xuanfei Baidu granule on host metabolism and gut microbiome in rats

Shi

Xing

et al. 2022

Front. Pharmacol.

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Xuanfei Baidu granule (XFBD) is a recommended patented drug for the prevention and treatment of Corona Virus Disease 2019 (COVID-19), which is approved by the National Medical Products Administration. XFBD suppresses the over-activated immune response caused by inflammatory factor storms in COVID-19 infection. The intestine plays a crucial role in the immune system. The mass spectrometry based fecal metabolomics with 16S rDNA sequencing were combined to evaluate the effects of XFBD on host metabolism and gut microbiome. Short-chain fatty acids (SCFAs) contents in fecal matter were quantified by gas chromatography-mass spectrometry (GC-MS). Plasma samples were used to detect immune and inflammatory levels. The results were verified with a rat model of intestinal disorder. Results indicated that XFBD could increase the immune level of Immunoglobulin A (IgA), Immunoglobulin G (IgG) and Immunoglobulin M (IgM) (p < 0.05). The OPLS-DA analysis results showed that a total of 271 differential metabolites (178 up-regulated and 93 down-regulated) were identified based on the VIP ≥1, p < 0.05, FC ≥ 2 and FC ≤ 0.5. The metabolic pathways mainly involved D-Glutamine and D-glutamate metabolism, Arginine biosynthesis, Biotin metabolism, et al. XFBD modified the gut bacteria structure according to the principal component analysis (PCA), that is, 2 phyla, 3 classes, 5 orders, 11 families and 14 genera were significantly different based on taxonomic assignment. In addition, it could partially callback the relative abundance of intestinal microflora in bacterial disorder rats caused by antibiotics. It is suggested that the intervention mechanism of XFBD might be related to the regulation of intestinal flora composition. The evidence obtained in the study provides a useful reference for understanding the mechanism of XFBD.

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“…The traditional Chinese medicine prescriptions such as Jinhua qinggan granule 92 , Lianhua Qingwen capsule/granule 93 , Xuebijing injection 94 , Lung Cleaner (Qingfei Paidu decoction) 95 , cure14 (Huashi Baidu granules) 96 , XuanFei Baidu granules 97 , 98 , 99 are collectively termed “three medicines and three formulas”. Besides the above 6 prescriptions, other traditional Chinese medicine prescriptions, such as Fuzheng Huayu tablets 100 , Buzhong Yiqi decoction 101 , Hanshiyi formula 102 , 103 , Reduning injection 104 , 105 , 106 , Tanreqing injection 107 , 108 and FuzhengJiedu granules 109 , 110 , etc.…”

Section: Traditional Chinese Medicinementioning

confidence: 99%

Research and development of Chinese anti-COVID-19 drugs

Meng

Zhu

et al. 2022

Acta Pharmaceutica Sinica B

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Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway

Cited by 40 publications

References 39 publications

Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Modulating effect of Xuanfei Baidu granule on host metabolism and gut microbiome in rats

Research and development of Chinese anti-COVID-19 drugs

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