XtalFluor‐E: An Efficient Reagent for Synthesis of Oxazolines from Carboxylic Acids and <i>O</i>‐Silylated Amino Alcohols

Kumar, Vadiga Shanthi; Gudise, Veera Babu; Reddy, Eeda Koti; Anwar, Shaik

doi:10.1002/jhet.3642

Cited by 8 publications

(1 citation statement)

References 55 publications

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“…Oxazoline and their derivatives have been found to have pharmacological activities 14 , anticancer activity 15,16 antibacterial, antitumor, antidepressant, and anti-Alzheimer's activities. [17][18][19][20][21][22][23] The antioxidant properties of aryl-substituted 2-oxazolines have recently been investigated. [24][25][26] Our present In-silico studies of 2-aryloxazoline compounds which were synthesized and showed the antifungal activity with low cytotoxicity by Luis M. Z. Argomedo, and et al (Scheme 1).…”

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confidence: 99%

In-silico investigations on the anticancer activity of selected 2-aryloxazoline derivatives that inhibit fatty acid synthase (FASN)

Rani

Nath

Kumer

2022

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As the in-silico study has become an important tool to search the new drugs in the concurrent era with towering acceptance and accuracy, it is executed in our research for unearthing the effective cancer drugs. To say more, breast cancer has accounted for the serious diseases for both men and women although few research outputs have been obtained on breast cancer that is not an adequate amount to ascertain new drugs. Due to this gap, the virtual screening, In-silico study, provides the ability to design and select by quickly identifying anticancer compounds with desirable drug-like properties. A total of nine 2-aryloxazoline derivatives were chosen, and In-silico was studied as a potential anticancer agent with the comparison of seven Food and Drug Administration (FDA) approved breast cancer drugs. These compounds were subjected to computational ADME and Lipinski analysis, as well as molecular docking and molecular dynamics simulations calculations against a variety of therapeutic targets involved in cell proliferation (PDB ID: 3TJM, 3ERT, 4OAR, 2J6M). An in-silico docking study reveals that ligands Hit-4, Hit-6, and Hit-8 had the highest docking scores of -10.3 kcal/mole − 10.3 kcal/mole, and − 10.2 kcal/mole towards Fatty Acid Synthase. The ligands had docking scores better than the standard anti-breast cancer drug gefitinib (− 5.3 kcal/mole). Our studies show the significance of pharmaceutical researchers in designing and developing new anticancer breast cancer drugs.

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Section: Introductionmentioning

confidence: 99%

In-silico investigations on the anticancer activity of selected 2-aryloxazoline derivatives that inhibit fatty acid synthase (FASN)

Rani

Nath

Kumer

2022

Preprint

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Organocascade Synthesis of Spiro[chroman‐3,2′‐indanedione] Scaffolds via [4+2] or [1+1+4] Cyclisation

et al. 2021

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A simple and convenient protocol has been demonstrated for the construction of spiro[chroman‐3,2′‐indanedione] via Oxa‐Michael/Michael cascade reaction sequence using 2‐arylidene‐1,3‐indanedione and (E)‐2‐(2‐nitrovinyl)phenol. This [4+2] cyclisation protocol results in the generation of two stereocentres along with an all carbon quaternary centre in good to high chemical yields of upto 93 %. A triple cascade reaction approach was carried out for the construction of spiro[chroman‐3,2′‐indanedione] using [1+1+4] cyclisation protocol.

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Advancements in the synthesis of oxazolines

2022

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XtalFluor‐E: An Efficient Reagent for Synthesis of Oxazolines from Carboxylic Acids and O‐Silylated Amino Alcohols

Cited by 8 publications

References 55 publications

In-silico investigations on the anticancer activity of selected 2-aryloxazoline derivatives that inhibit fatty acid synthase (FASN)

In-silico investigations on the anticancer activity of selected 2-aryloxazoline derivatives that inhibit fatty acid synthase (FASN)

Organocascade Synthesis of Spiro[chroman‐3,2′‐indanedione] Scaffolds via [4+2] or [1+1+4] Cyclisation

Advancements in the synthesis of oxazolines

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