XRD and ATR-FTIR techniques for integrity assessment of gamma radiation sterilized cortical bone pretreated by antioxidants

El-Hansi, Naglaa S.; Said, Hoda H.; Desouky, Omar S.; Khalaf, Mahmoud; Talaat, M.S.; Sallam, Al-Aliaa M.

doi:10.1007/s10561-020-09879-4

Cited by 7 publications

(2 citation statements)

References 82 publications

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“…For example, in non-mineralized collagen in dried tendon, damage induced by X-rays is identified following ionization due to exposure to 12 kGy 22 . This is known as “primary radiation damage” and has been shown to split polypeptide chains 23 , 24 or destroy organic crystals 14 . On the other hand, hydrated tendon samples exhibit degradation only after exposure to ~20 kGy.…”

Section: Introductionmentioning

confidence: 99%

“…This suggests that water slows-down collagen ionization or shields the fibers from direct damage, despite free radical formation by radiolysis 25 , 26 . When this occurs, reactive species induce structural degradation known as “secondary radiation damage”, mediated for example by mobile OH-radicals 2 , 24 , 27 . Yet the higher doses sustained by wet collagen, at least initially, suggest that overall, the tissue is less damaged and that a smaller portion of the impinging radiation energy actually directly ionizes and fragments the fibers in the material.…”

Section: Introductionmentioning

confidence: 99%

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Primary radiation damage in bone evolves via collagen destruction by photoelectrons and secondary emission self-absorption

et al. 2022

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X-rays are invaluable for imaging and sterilization of bones, yet the resulting ionization and primary radiation damage mechanisms are poorly understood. Here we monitor in-situ collagen backbone degradation in dry bones using second-harmonic-generation and X-ray diffraction. Collagen breaks down by cascades of photon-electron excitations, enhanced by the presence of mineral nanoparticles. We observe protein disintegration with increasing exposure, detected as residual strain relaxation in pre-stressed apatite nanocrystals. Damage rapidly grows from the onset of irradiation, suggesting that there is no minimal ‘safe’ dose that bone collagen can sustain. Ionization of calcium and phosphorous in the nanocrystals yields fluorescence and high energy electrons giving rise to structural damage that spreads beyond regions directly illuminated by the incident radiation. Our findings highlight photoelectrons as major agents of damage to bone collagen with implications to all situations where bones are irradiated by hard X-rays and in particular for small-beam mineralized collagen fiber investigations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary radiation damage in bone evolves via collagen destruction by photoelectrons and secondary emission self-absorption

et al. 2022

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Assessment of bone dose response using ATR-FTIR spectroscopy: A potential method for biodosimetry

Castro

Dias

Del-Valle

et al. 2022

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Structural Changes in Cortical Bone After Bombardment With Low-Energy Hydrogen Ions

DESOUKY,

ABDELREHEEM,

EL-MARAKBY

et al. 2024

Surf. Rev. Lett.

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Radiobiological studies focused mainly on tracking the effects of photons (X and gamma rays) and high-energy charged particles over low energy ions, which raises interest in studying their biological effects. Therefore, the aim of this study is to investigate the interaction of low-energy hydrogen ions beam with xcortical bovine bone as a biological model. A hydrogen ions beam was used to bombard cortical bone with different fluences; 45, 70 and [Formula: see text][Formula: see text]ions/cm2 at low energy of 5[Formula: see text]keV. The interaction of hydrogen ions with cortical bone was estimated theoretically by the SRIM/TRIM code. The obtained results showed that the average distribution range and the maximum depth for 5[Formula: see text]keV hydrogen ions are 91 and 150[Formula: see text]nm respectively. The energy losses from incident ions are 4.45[Formula: see text]keV for ionization, 170[Formula: see text]eV for phonons and 18[Formula: see text]eV for vacancies. Also, the energy losses from the recoil atoms are 119[Formula: see text]eV for ionization, 234[Formula: see text]eV for phonons and 8[Formula: see text]eV for vacancies. At the same time, the effect of low-energy hydrogen ions bombardment on the structure of bone was studied by X-ray diffraction (XRD) and FTIR.

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XRD and ATR-FTIR techniques for integrity assessment of gamma radiation sterilized cortical bone pretreated by antioxidants

Cited by 7 publications

References 82 publications

Primary radiation damage in bone evolves via collagen destruction by photoelectrons and secondary emission self-absorption

Primary radiation damage in bone evolves via collagen destruction by photoelectrons and secondary emission self-absorption

Assessment of bone dose response using ATR-FTIR spectroscopy: A potential method for biodosimetry

Structural Changes in Cortical Bone After Bombardment With Low-Energy Hydrogen Ions

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