XRD, AFM, IR and TGA study of nanostructured hydroxyapatite

Mir, Mirta; Leite, Fábio L.; Herrmann, P. S. de P.; Pissetti, Fábio L.; Rossi, Alexandre Malta; Moreira, Elizabeth L.; Mascarenhas, Yvonne P.

doi:10.1590/s1516-14392012005000069

Cited by 38 publications

(32 citation statements)

References 19 publications

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“…This demonstrated that there were chemical interactions between β-TCP material and SBF solution. These interactions would lead to the commute of β-TCP (beta-tricalcium phosphate) to HA (hydroxyapatite) versus time and continued until β-TCP completely transformed into HA (Mirta et al 2012). Obtained result confirmed the bioactivity of β-TCP. )…”

Section: Physico-chemical Characterizationsupporting

confidence: 53%

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Synthesis and in vitro Experiment of Biomaterial Tricalcium Phosphate

Bui¹

2016

AJSTD

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Calcium phosphate ceramics consist of materials such as hydroxyapatite, tricalcium phosphate (TCP), calcium phosphate cement (CPC), biphasic calcium phosphate, etc. CPCs have been used for filling bone defects in dentistry and orthopedics. Among these materials, β-tricalcium phosphate is suggestedas an ideal candidate for bone graft in hard tissue engineering due to its high biocompatibility, bioactivity and bone bonding. The preparation, as well as the application of this powder material, has been the important topic of research in material science. In this paper, β-tricalcium phosphate (β-TCP), a component that has chemical formulation similar to bone structure, was synthesized by the precipitate method and then calcinated at 1000oC for 5 h. The physico-chemical properties of synthetic material were examined by XRD, FT-IR and SEM methods. In vitro experience was also carried by soaking β-TCP simulated body fluid powder in a different period of time. Obtained results confirmed the quality of β-TCP synthetic material and its bioactivity.

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Section: Physico-chemical Characterizationsupporting

confidence: 53%

“…Obtained result confirmed the bioactivity of β-TCP. ) (Mirta et al 2012). That demonstrated that after 5 days in SBF solution, β-TCP had transferred one part into HA.…”

Section: Physico-chemical Characterizationmentioning

confidence: 96%

Synthesis and in vitro Experiment of Biomaterial Tricalcium Phosphate

Bui¹

2016

AJSTD

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“…[20][21][22] The weak shoulder at 964 cm −1 and the broadband at 1033 cm −1 with shoulder at 1093 cm −1 correspond to the vibrational modes of stretch ν 1 and ν 3 of the phosphate group (PO 4 3− ), while the shoulder at 474 cm −1 and the strong bands at 566 and 601 cm −1 indicate the presence of the vibrational modes ν 2 and ν 4 of flexion of this same group. 22 The bands related to the stretching of the hydroxyl group (OH − ) can be observed at 3575 and 630 cm −1 , 21 and they gradually decrease while the Sr concentration increases. According to Frasnelli et al, 12 the deformation of the HA unit cell in the c-axis can lead to a limitation in spatial density of the bonds of the OH − .…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 97%

⁸⁹Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors

Rezende

Andrade

Cipreste

et al. 2019

Int J Applied Ceramic Tech

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Hydroxyapatite (HA) nanoparticles have been studied due to their high biocompatibility, similarity with bone tissue, and their capacity for bone regeneration since these nanoparticles can easily adhere on osteosarcoma and osteoblast cells, promoting osteoblast growth and osteosarcoma cell uptake. These materials may still accumulate spontaneously and selectively in regions of bone tumors through the enhanced permeability and retention effect. HA also allows the incorporation of strontium in your network. Strontium as a biochemical analog of calcium can maintain the osteogenesis characteristics of HA allowing the production of the radioactive isotopes strontium‐89 and phosphorus‐32 through neutron irradiation. These radioisotopes are beta emitters that enable the treatment of bone tumors, while the affected region is regenerated. In this work, we investigated the synthesis of strontium‐doped HA nanorods through the hydrothermal coprecipitation method as a potential therapeutic agent for bone tumors. All materials were successfully obtained and demonstrated high cell viability, maintaining the osteogenic capacity, making these materials promising agents for the specific treatment of bone tumors. The results indicate that the Sr provides an increase in therapeutic potential due to its beta emission.

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“…An increase in calcination temperature results in narrowing and sharpening of diffraction peaks as an indicator of raised crystallinity and an increase in crystal/grain size. 49 Further increase in temperature leads to dehydroxylation as a result of the separation of structural OH − group with corresponding changes in absorption bands at 630 and 3572 cm −1 . 48 Furthermore, the thermal treatment can also induce non-structural and structural changes in the phase composition of biomaterials that can be traced as alterations in FTIR absorption bands.…”

Section: Modification Of Calcination Parameters and Their Importancementioning

confidence: 99%

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

Ebrahimi

Botelho

et al. 2019

J Biomedical Materials Res

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Calcium phosphate bioceramics nanoparticles such as nano‐hydroxyapatite (nHA) and nano‐tricalcium phosphate (nTCP) are the main focus of basic and applied research for bone tissue regeneration. In particular, a combination of these two phases (nHA + nTCP) which refers to as “nano‐biphasic calcium phosphates (nBCP)” is of interest due to the preferred biodegradation nature compared to single‐phase bioceramics. However, the available synthesis processes are challenging and the biomaterials properties are yet to be optimized to mimic the physiochemical properties of the natural nanoscale bone apatite. In this study, a new approach was developed for the production of optimized bioceramic nanoparticles aiming to improve their biomimecity for better biological performances. Nanoparticles were synthesized through a carefully controlled and modified wet mechano‐chemical method combined with a controlled solid‐state synthesis. Different processing variables have been analyzed including; milling parameters, post‐synthesis treatment, and calcination phase. Detailed physicochemical characterizations of nanoparticles revealed higher crystallinity (∼100%), lower crystallite/particle size (58 nm), higher homogeneity, reduced particle agglomeration size (6 μm), and a closer molar ratio (1.8) to biological apatite compared to control and standard samples. Furthermore, the study group was confirmed as calcium‐deficient carbonate‐substituted BCP nanoparticles (nHA/nβ‐TCP: 92/8%). As such, the introduced method can afford an easier and accurate control over nanoparticle physiochemical properties including the composition phase which can be used for better customization of biomaterials for clinical applications. The findings of this article will also help researchers in the further advancement of production strategies of biomaterials. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1654–1666, 2019.

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XRD, AFM, IR and TGA study of nanostructured hydroxyapatite

Cited by 38 publications

References 19 publications

Synthesis and in vitro Experiment of Biomaterial Tricalcium Phosphate

Synthesis and in vitro Experiment of Biomaterial Tricalcium Phosphate

⁸⁹Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

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XRD, AFM, IR and TGA study of nanostructured hydroxyapatite

Cited by 38 publications

References 19 publications

Synthesis and in vitro Experiment of Biomaterial Tricalcium Phosphate

Synthesis and in vitro Experiment of Biomaterial Tricalcium Phosphate

89Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

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⁸⁹Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors