XRCC3 T241M polymorphism and lung cancer risk in the Han Chinese population: a meta-analysis

Abstract

ABSTRACT. Numerous studies have evaluated the association between the X-ray repair cross-complementing group 3 (XRCC3) T241M polymorphism and lung cancer risk; however, the actual association is controversial. We examined whether the T241M polymorphism confers a lung cancer risk in China. We searched the PubMed, Google Scholar, and China National Knowledge Infrastructure databases to identify studies that examined the association between the XRCC3 T241M polymorphism and the risk of lung cancer. We estimated the pooled odds ratio with its 95% confidence interval to assess this association. A total of 3977 patients with lung cancer and 3761 controls from 8 comparative studies were included in this meta-analysis. The meta-analysis results revealed no significant association between the XRCC3 T241M polymorphism and lung cancer risk. In the subgroup analysis, 6 studies with sample sizes over 500 found that the T241M polymorphism had no association with lung cancer. The XRCC3 T241M polymorphism may not be a risk factor for lung cancer. However, larger studies involving a stratified case-control population and biological characterization are needed to validate this finding.

Genetic susceptibility of lung cancer in Chinese population: An overview of systematic reviews and meta‐analyses

“…After excluding the reviews did not report the results, we found that the reviews finally included 20 meta‐analyses. The 20 meta‐analyses included 21 polymorphisms from 19 genes . All polymorphisms were analyzed by more than five case‐control studies in the original meta‐analysis (Table ).…”

“…There were eight meta‐analyses published in 2015 . All meta‐analyses were published in 11 different journals: including nine English journals and two Chinese journals . All English journals were indexed by Web of Science.…”