“…Similar to findings in adult malignancies, XPO1 inhibitors in pediatric cancers have been found to induce a G1 cell cycle arrest, leading to a decrease in cells entering S/G2, in leukemia, neuroblastoma, MRT, and ATRT [ 30 , 89 , 90 , 91 , 95 ]. Further, XPO1-directed therapy has been shown to upregulate apoptosis in leukemia, high-grade glioma, ATRT, neuroblastoma, MRT, and sarcoma [ 30 , 89 , 90 , 91 , 93 , 94 , 95 ]. In acute leukemia, Etchin et al demonstrated the effect of KPT-185 on G1 cell cycle arrest and showed that the majority of apoptosis is induced at G1 [ 89 ].…”