XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis

Cheng, Teng; Wei, Rui; Jiang, Guiying; Zhou, Ying; Lv, Mengqin; Dai, Yun; Yuan, Yuan; Luo, Danfeng; Ma, Ding; Li, Fēi; Liu, Xi

doi:10.1177/1010428317717122

Cited by 16 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it is known that this aminopeptidase activates growth factors, hormones, coagulants, toxins, cytokines and neurotransmitters [115], the role of XPNPEP2 in cancer is still unknown. It is known that XPNPEP2 is overexpressed in cervical cancer, promoting cell invasion and migration without affecting cell proliferation and apoptosis [116]. Our gene expression results corroborate these findings and point out that XPNPEP2 can be up-regulated in GBM.…”

Section: Gene Expression Validation Of the Microarray Resultssupporting

confidence: 89%

Genomic and Transcriptomic Characterization of the New Human Glioblastoma Cell Line AHOL1

Ferreira¹,

Amorim²,

Burbano³

et al. 2019

Preprint

View full text Add to dashboard Cite

Cancer cell lines are widely used as in vitro models of tumorigenesis, facilitating fundamental discoveries in cancer biology and translational medicine. Currently, there are few options for glioblastoma (GBM) treatment and limited in vitro models with accurate genomic and transcriptomic characterization. Here, a detailed characterization of a new GBM cell line, namely AHOL1, was conducted in order to fully characterize its molecular composition based on its copy number alteration (CNA) and transcriptome profiling, followed by the validation of key elements associated with GBM tumorigenesis. Large numbers of CNAs and differentially expressed genes (DEGs) were identified. CNAs were distributed throughout the genome, including gains at Xq11.1-q28, Xp22.33-p11.1, Xq21.1-q21.33, 4p15.1-p14, 8q23.2-q23.3 and losses at Yq11.21-q12, Yp11.31-p11.2 and 12p13.31 positions. Nine druggable genes were identified, including HCRTR2, ETV1, PTPRD, PRKX, STS, RPS6KA6, ZFY, USP9Y and KDM5D. By integrating DEGs and CNAs, we identified 57 overlapping genes enriched in fourteen pathways. Altered expression of several cancer-related candidates found in the DEGs-CNA dataset was confirmed by RT-qPCR. Taken together, this first comprehensive genomic and transcriptomic landscape of AHOL1 provides unique resources for further studies and identifies several druggable targets that may be useful for therapeutics and biologic and molecular investigation of GBM.

show abstract

Section: Gene Expression Validation Of the Microarray Resultssupporting

confidence: 89%

Genomic and Transcriptomic Characterization of the New Human Glioblastoma Cell Line AHOL1

Ferreira¹,

Amorim²,

Burbano³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…XPNPEP2 serves a vital role in the ovarian breakdown and follicular dysplasia induced by hexavalent chromium in rat germ cells (33). XPNPEP2 overexpression is also observed in cervical cancer tissues, and is associated with pathological staging, lymph node metastasis and poor OS (34), which coincides with the results from the present study findings in the XPNPEP2 study in OSC, in renal clear cell carcinoma (CCRCC) (35) and in advanced gastric cancer (36).…”

Section: Discussionsupporting

confidence: 91%

Identification of a 3‑mRNA signature as a novel potential prognostic biomarker in patients with ovarian serous cystadenocarcinoma in G2 and G3

Zhou

Wang

et al. 2019

Oncol Lett

View full text Add to dashboard Cite

The use of mRNAs as biomarkers serves to diagnose, treat, as well as aid the prognosis of cancer. The present study involved an analysis of mRNAs in the cell cycle at the G2 and G3 tumor grades for the prognosis of ovarian serous cystadenocarcinoma (OSC) using 364 clinical samples (G2:G3=42:322). Statistics aided the identification of NPFFR2, XPNPEP2 and CELA3B; the 3-mRNA model that allows for classification of patients into high- and low-risk groups using a median value of 0.9580745. The rates of survival varied (P=0.00149) and the independent detection of stratification of the risk of this disease was validated with success using the 3-mRNA signature, which was demonstrated to be more successful than the weight model. This approach was revealed to provide the prognosis of grade G2 and G3 in patients with OSC compared with factors used traditionally. Compared with traditional factors, this 3-mRNA model was demonstrated to be the only and independent prognostic factor for patients with G2 and G3 stage OSC. A literature survey was also performed in the present study in order to assess the role of the 3 genes and indirectly prove their effectiveness. The establishment of this new genetic model will enhance prospective prognosis and treatment for patients with OSC.

show abstract

“…MMP9 is a member of the matrix metalloproteinase family, which has a role in degradation of the extracellular matrix and promotes tumor invasion and metastasis 26 . XPNPEP2 (also known as aminopeptidase P) was reported to facilitate cervical cancer cell invasion and migration by mediating the EMT) 27 . GSEA 25 showed that 15 pathways were significantly enriched in thrombi, most of which were related to the immune response, such as the lymphocyte proliferation, lysosome, and inflammatory response pathway.…”

Section: Resultsmentioning

confidence: 99%

Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus

et al. 2020

View full text Add to dashboard Cite

Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRCC associated with tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing on 110 normal-tumor pairs and 42 normal-tumor-thrombus triples, and transcriptome sequencing on 61 tumor-normal pairs and 30 primary-thrombus pairs from 152 Chinese patients with ccRCC. Our analysis reveals that a mutational signature associated with aristolochic acid (AA) exposure is widespread in Chinese ccRCC. Tumors from patients with ccRCC-TT show a higher mutational burden and genomic instability; in addition, mutations in BAP1 and SETD2 are highly enriched in patients with ccRCC-TT. Moreover, patients with/without TT show distinct molecular characteristics. We reported the integrative genomic sequencing of Chinese ccRCC and identified the features associated with tumor thrombus, which may facilitate ccRCC diagnosis, prognosis and treatment.

show abstract

XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis

Cited by 16 publications

References 22 publications

Genomic and Transcriptomic Characterization of the New Human Glioblastoma Cell Line AHOL1

Genomic and Transcriptomic Characterization of the New Human Glioblastoma Cell Line AHOL1

Identification of a 3‑mRNA signature as a novel potential prognostic biomarker in patients with ovarian serous cystadenocarcinoma in G2 and G3

Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus

Contact Info

Product

Resources

About