Xpitx3 : a member of the Rieg/Pitx gene family expressed during pituitary and lens formation in Xenopus laevis

Pommereit, Dagmar; Pieler, Tomas; Hollemann, Thomas

doi:10.1016/s0925-4773(01)00305-7

Cited by 44 publications

(34 citation statements)

References 16 publications

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“…Lanctot et al, 1997;Pommereit et al, 2001) and contact the adenohypophyseal placode in amphibians (Kawamura and Kikuyama, 1992) and hagfish (Gorbman, 1983). We tested these predictions by analyzing the expression of Oikopleura pitx and Six genes in larvacean embryos and hatchlings.…”

Section: Eya Pitx and Six Gene Expression In The Ventral Organmentioning

confidence: 99%

The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioica

Bassham

Postlethwait

2005

Development

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The evolutionary origin of vertebrate placodes remains controversial because divergent morphologies in urochordates, cephalochordates and vertebrates make it difficult to recognize organs that are clearly homologous to placode-derived features, including the olfactory organ, adenohypophysis, lens, inner ear, lateral line and cranial ganglia. The larvacean urochordate Oikopleura dioica possesses organs that morphologically resemble the vertebrate olfactory organ and adenohypophysis. We tested the hypothesis that orthologs of these vertebrate placodes exist in a larvacean urochordate by analyzing the developmental expression of larvacean homologs of the placode-marking gene families Eya, Pitx and Six. We conclude that extant chordates inherited olfactory and adenohypophyseal placodes from their last common ancestor, but additional independent proliferation and perhaps loss of placode types probably occurred among the three subphyla of Chordata.

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Section: Eya Pitx and Six Gene Expression In The Ventral Organmentioning

confidence: 99%

The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioica

Bassham

Postlethwait

2005

Development

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“…CAK has been shown to play a role in the activation of cdks as well as in the function of TFIIH and RNA polymerase II. Retroviral transduction of antisense Mat1 constructs into fetal human lens (Pannese et al, 1995;Kablar et al, 1996;Hirsch and Harris, 1997;Penzel et al, 1997;Zygar et al, 1998;Schaefer et al, 1999;Kenyon et al, 1999;Hollemann and Pieler, 1999;Zhou et al, 2000;Ishibashi and Yasuda, 2001;Pommereit et al, 2001).…”

Section: A Profile Of Gene Expression In Transdifferentiating Cornea mentioning

confidence: 99%

Characterizing gene expression during lens formation in Xenopus laevis: Evaluating the model for embryonic lens induction

Henry

Carinato

Schaefer

et al. 2002

Developmental Dynamics

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Few directed searches have been undertaken to identify the genes involved in vertebrate lens formation. In the frog Xenopus, the larval cornea can undergo a process of transdifferentiation to form a new lens once the original lens is removed. Based on preliminary evidence, we have shown that this process shares many elements of a common molecular/genetic pathway to that involved in embryonic lens development. A subtracted cDNA library, enriched for genes expressed during cornea-lens transdifferentiation, was prepared. The similarities/identities of specific clones isolated from the subtracted cDNA library define an expression profile of cells undergoing cornea-lens transdifferentiation ("lens regeneration") and corneal wound healing (the latter representing a consequence of the surgery required to trigger transdifferentiation). Screens were undertaken to search for genes expressed during both transdifferentiation and embryonic lens development. Significantly, new genes were recovered that are also expressed during embryonic lens development. The expression of these genes, as well as others known to be expressed during embryonic development in Xenopus, can be correlated with different periods of embryonic lens induction and development, in an attempt to define these events in a molecular context. This information is considered in light of our current working model of embryonic lens induction, in which specific tissue properties and phases of induction have been previously defined in an experimental context. Expression data reveal the existence of further levels of complexity in this process and suggests that individual phases of lens induction and specific tissue properties are not strictly characterized or defined by expression of individual genes.

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“…Moreover, members of the fibroblast growth factor (FGF) family, which specify retinal fate (Nguyen and Arnheiter, 2000), emanate from the lens ectoderm, and are known to promote proliferation of retinal progenitor cells (Chow and Lang, 2001). Accordingly, expression of the lens placode marker Xpitx3 (Pommereit et al, 2001) was reduced (data not shown). The small eye phenotype (Fig.…”

Section: Overexpression Of Mdhcr7 May Impair Eye Formation Through Anmentioning

confidence: 97%

Cholesterol homeostasis in development: The role of Xenopus 7‐dehydrocholesterol reductase (Xdhcr7) in neural development

Tadjuidje¹,

Hollemann²

2006

Developmental Dynamics

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7-dehydrocholesterol reductase (7-Dhcr) catalyses the final step in the pathway of cholesterol biosynthesis. Human patients with inborn errors of 7-Dhcr (Smith-Lemli-Opitz-Syndrome) have elevated serum levels of 7-dehydrocholesterol but low levels of cholesterol, which in phenotypical terms can result in growth retardation, craniofacial abnormalities including cleft palate, and reduced metal abilities. This study reports the isolation and molecular characterisation of 7-dehydrocholesterol reductase (Xdhcr7) from Xenopus laevis. During early embryonic development, the expression of Xdhcr7 is first of all spatially restricted to the Spemann's organizer and later to the notochord. In both tissues, Xdhcr7 is coexpressed with Sonic hedgehog (Shh), which itself is cholesterol-modified during autoproteolytic cleavage. Data from Xdhcr7 overexpression and knockdown experiments reveals that a tight control of cholesterol synthesis is particularly important for proper development of the central and peripheral nervous system.

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Xpitx3 : a member of the Rieg/Pitx gene family expressed during pituitary and lens formation in Xenopus laevis

Cited by 44 publications

References 16 publications

The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioica

The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioica

Characterizing gene expression during lens formation in Xenopus laevis: Evaluating the model for embryonic lens induction

Cholesterol homeostasis in development: The role of Xenopus 7‐dehydrocholesterol reductase (Xdhcr7) in neural development

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