XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck

DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

“…There are two described polymorphisms that induce amino acid changes in the protein: at codons 312 (Asp to Asn) and 751 (Lys to Gln) (87)(88)(89). To date, these two polymorphisms have been extensively studied (87,88,(90)(91)(92)(93)(94)(95).…”

Genetic Associations of 115 Polymorphisms with Cancers of the Upper Aerodigestive Tract across 10 European Countries: The ARCAGE Project

“…The association between different variants in these pathways and UADT cancer has been investigated in multiple studies, but the results are inconsistent (19)(20)(21)(22)(23)(24)(25).…”

Identification of genetic polymorphisms in DNA repair xenoderma pigmentosum group D gene and its association with head and neck cancer susceptibility in rural Indian population: a hospital based case-control study from south-western Maharashtra, India

“…The investigations into the relationship between polymorphisms in DNA repair genes and susceptibility to environmental cancer have not yet produced consistent results. [20][21][22][23][24][25][26][27][28][29][30] However, there is an inconsistency most likely due to the complexity of the biological process and of molecular epidemiological investigations.…”

“…14,[16][17][18][19]21 Whereas few other studies failed to find positive evidence for XPD polymorphisms in squamous cell carcinoma of the head and neck (SCCHN) or melanoma. [20][21][22][23][24][25][26][27][28][29][30][31][32] Very few studies from Northern and Southern India have reported the genetic polymorphisms in the DNA repair genes with respect to a variety of cancer risks including prostate, breast, oral and esophageal cancers. [33][34][35] However, very limited information is available on the association of genetic polymorphisms of DNA repair genes including NER pathway genes and their susceptibility to oral cancer from rural population of Maharashtra where the rate of tobacco and alcohol consumption is very high.…”

“…[14][15][16][17][18][19] Few molecular epidemiologic studies have evaluated the association of HNC with functional genetic variants in the XPD genes, but in some of the studies the results are contradictory rather than convincing. [20][21][22][23][24][25] Also, the earlier observations were not consistent in terms of their roles in oral cancer susceptibility and therefore the influence of the polymorphisms of XPD genes on DNA repair capacity is still unclear. It is also uncertain which DNA repair pathway genes may be more important for protection against head and neck cancer.…”