XLVII.—The action of caustic alkali on α-bromo-α-ethylbutyrylcarbamide

Newbery, George

doi:10.1039/ct9252700295

Cited by 8 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The yield was increased to 65 per cent when the bromoureide was boiled with aqueous ammonium carbonate instead of potassium hydroxide (21), but similar conditions did not improve yields in the cyclization of "-alkyl-or N'-arylbromoacylureas. a-Bromoa-ethylbutyrylurea (adalin, carbromal) gave 5,5-diethyl-4-oxazolidone when treated with alkali (135).…”

Section: -Dichloromethylene-3-phenylmentioning

confidence: 99%

2,4-Oxazolidinediones

Clark-Lewis¹

1958

Chem. Rev.

View full text Add to dashboard Cite

Section: -Dichloromethylene-3-phenylmentioning

confidence: 99%

2,4-Oxazolidinediones

Clark-Lewis¹

1958

Chem. Rev.

View full text Add to dashboard Cite

“…Except for XII, these acylureas were prepared by reaction of the corresponding acyl chloride (or bromide) with urea (Spielman, Geiszler & Close, 1948). The structural isomer of carbromal, XII, was prepared by treating ectylurea with 45% w/v hydrogen bromide in glacial acetic acid as described by Newbery (1925). The acylureas were all colourless, crystalline solids after crystallization from aqueous ethanol or toluene.…”

Section: R I Mrongovius and M J Randmentioning

confidence: 99%

A Study in Mice of Bromo and Chloro Acylurea Analogues of the Sedative‐hypnotic Bromureides

Mrongovius

Rand

1977

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. A series of 1-(2-chloroacyl)ureas, related to the sedative-hypnotic drugs bromvaletone and carbromal, was synthesized and tested in mice to determine central depressant and acute toxic effects. Four 1-(2-bromoacyl)ureas and two 3-halo compounds were included for comparison. 2. Large variations in potency were seen between the compounds. Much of this can be ascribed to differences in lipophilicity. Among homologous 1-(2-chloroacyl)ureas, those with 6 acyl carbons had maximal potency. Among groups of structural isomers, the most potent were 2-halo, 3-alkyl substituted compounds. 3. The most potent compounds were also those with the largest ratios of hypnotic to lethal activity. 4. The variation in the onset and duration of action of these compounds enables a choice to be made for a compound with a particular set of characteristics.

show abstract

Hypnotics

Wollweber

2000

Ullmann's Encyclopedia of Industrial Chemistry

View full text Add to dashboard Cite

The article contains sections titled: 1. Introduction 1.1. Amino Acids and Hormones Influencing Sleep 1.2. Influence of Hypnotics on Sleep 1.3. Requirements of Hypnotics 1.4. Applications of Hypnotics 1.5. Consumption of Hypnotics 1.6. Classification and Evaluation of Hypnotics 2. Sedatives, Antihistamines, and Tranquilizers 3. Alcohols and Aldehydes 4. Urethanes, Acyclic Urea Derivatives, and Amides 5. Cyclic Carboxamides, Carboximides, Cyclic Urea Derivatives, and Related Compounds 5.1. Barbituric Acids 5.2. Piperidinediones 5.3. Quinazolinones 5.4. Benzodiazepines 6. Other Hypnotics

show abstract

XLVII.—The action of caustic alkali on α-bromo-α-ethylbutyrylcarbamide

Cited by 8 publications

References 0 publications

2,4-Oxazolidinediones

2,4-Oxazolidinediones

A Study in Mice of Bromo and Chloro Acylurea Analogues of the Sedative‐hypnotic Bromureides

Hypnotics

Contact Info

Product

Resources

About