XJB-5-131 protects chondrocytes from ferroptosis to alleviate osteoarthritis progression via restoring Pebp1 expression

Sun, Wei; Lv, Zhongyang; Li, Weitong; Lu, Jun; Xie, Ya; Wang, Peng; Jiang, Ruiyang; Dong, Jian; Guo, Hu; Liu, Zizheng; Fei, Yuxiang; Tan, Guihua; Wang, Maochun; Ren, Kewei; Xu, Jun; Sun, Huiqing; Jiang, Xuefeng; Shi, Dongquan

doi:10.1016/j.jot.2023.12.005

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2024

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Cited by 4 publications

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The role of ferroptosis in osteoarthritis: Progress and prospects

Sheng,

Liao,

Wang

et al. 2024

Biochemical and Biophysical Research Communications

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The role of ferroptosis in osteoarthritis: Progress and prospects

Sheng,

Liao,

Wang

et al. 2024

Biochemical and Biophysical Research Communications

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Advances in osteoarthritis research: From diagnosis, treatment to mechanism studies

Lv,

Wang,

Chen

et al. 2024

Journal of Orthopaedic Translation

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Hypoxia impedes differentiation of cranial neural crest cells into derivatives relevant for craniofacial development

Schmid,

Rodrian,

Kohler

et al. 2024

Preprint

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Orofacial clefts are the second-most prevalent congenital malformation. Risk factors are multifactorial and include genetic components but also environmental factors. One environmental factor is hypoxia during pregnancy, caused for instance by tobacco smoking, medication or living at high altitudes. Knowledge about the molecular link between hypoxia and orofacial clefts is at large. We here show that hypoxia has only modest effects on proliferating cranial neural crest cells, but dramatically influences their differentiation potential. We detected massive perturbations in their differentiation to chondrocytes, osteoblasts and smooth muscle cells. The transcriptional induction of the majority of regulated genes during each of these processes was grossly impaired by hypoxic conditions, as evidenced by genome-wide transcriptomic analyses. Bioinformatic analyses pointed to cytoskeletal organization and amino acid metabolism as two main processes compromised during all three differentiation pathways, and several orofacial cleft risk genes were among the genes with impaired induction during hypoxia. Our analyses reveal a drastic influence of hypoxia on the differentiation potential of cranial neural crest cells as a possible source for the occurrence of orofacial clefts.

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XJB-5-131 protects chondrocytes from ferroptosis to alleviate osteoarthritis progression via restoring Pebp1 expression

Cited by 4 publications

References 55 publications

The role of ferroptosis in osteoarthritis: Progress and prospects

The role of ferroptosis in osteoarthritis: Progress and prospects

Advances in osteoarthritis research: From diagnosis, treatment to mechanism studies

Hypoxia impedes differentiation of cranial neural crest cells into derivatives relevant for craniofacial development

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