XIX. Ueber einen bisher unbekannten Nebenapparat am Haarsystem des Menschen: Haarscheiben

Pinkus, Felix

doi:10.1159/000241971

Cited by 61 publications

(16 citation statements)

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“…As he saw an association with nerve Wbers, he assumed them to represent sensory organs and called them "Tastzellen" (touch cells). The association of these "clear cells" with nerves was conWrmed by Pinkus (1902) in human skin. It took about 70 years to clarify their hallmark by electron microscopy, namely the electron-dense membrane-surrounded neuroendocrine granules (Winkelmann and Breathnach 1973) containing speciWc neuropeptides and biogenic amines (Hartschuh and Grube 1979;Hartschuh and Weihe 1989;Hartschuh et al 1989b).…”

Section: Introductionmentioning

confidence: 88%

Evidence for distinct populations of human Merkel cells

Eispert

Fuchs

Brandner

et al. 2009

Histochem Cell Biol

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Merkel cells (MCs) are neuroendocrine cells of unknown origin located in the skin. They are identified at electron microscopic level by electron dense granules, at light microscopic level by the presence of cytokeratins 8, 18, 19 and 20. Contradictory reports concerning the presence of other molecules of epithelial as well as neural origin prompted us to investigate whether there are distinct populations of human MCs. Here, we show the heterogeneous expression of villin, N-CAM, NGF-R, and neurofilaments in MCs. Synaptophysin is found in all MCs but with different intensity, nestin is absent. Expression patterns vary between interfollicular epidermis, hair follicles and glabrous epidermis. We conclude that there are distinct populations of MCs, but all populations contain markers for epithelial as well as neural cells. Putative functions of the distinct populations are discussed.

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Section: Introductionmentioning

confidence: 88%

Evidence for distinct populations of human Merkel cells

Eispert

Fuchs

Brandner

et al. 2009

Histochem Cell Biol

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“…In hairy skin the so-called 'Tastscheibe" was primarly described by Pinkus (1902Pinkus ( , 1905, and for this reason it is also referred to as Pinkus corpuscle. With the assistance of light and electron microscopy, it has been deSCribed by several authors (Straile, 1960(Straile, , 1961Mann, 1968;Smith, 1967;Iggo and Muir, 1969;Straile and Mann, 1972;Fitzgerald et al, 1984).…”

Section: The "Tastscheibe" Of the Hairy Skinmentioning

confidence: 99%

Sensory Innervation of the Hairless and Hairy Skin in Mammals including Humans

Halata

1990

The Primary Afferent Neuron

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“…In the hairy skin of mice and humans the interfollicular epidermis (IFE) contains specialized epithelial structures termed touch domes (TDs) that consist of epidermal keratinocytes in juxtaposition with neuroendocrine Merkel cells (Moll et al, 1996a;Johnson et al, 2000;Johnson, 2001;Halata et al, 2003;Pinkus, 1902;Reinisch and Tschachler, 2005;Smith, 1977). Merkel cells are putative sensory mechanoreceptor cells that are thought to be required for the perception of light touch stimuli ).…”

Section: Introductionmentioning

confidence: 99%

Identification of epidermal progenitors for the Merkel cell lineage

et al. 2010

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Epithelial stem cells in adult mammalian skin are known to maintain epidermal, follicular and sebaceous lineages during homeostasis. Recently, Merkel cell mechanoreceptors were identified as a fourth lineage derived from the proliferative layer of murine skin epithelium; however, the location of the stem or progenitor population for Merkel cells remains unknown. Here, we have identified a previously undescribed population of epidermal progenitors that reside in the touch domes of hairy skin, termed touch dome progenitor cells (TDPCs). TDPCs are epithelial keratinocytes and are distinguished by their unique co-expression of α6 integrin, Sca1 and CD200 surface proteins. TDPCs exhibit bipotent progenitor behavior as they give rise to both squamous and neuroendocrine epidermal lineages, whereas the remainder of the α6+ Sca1+ CD200– epidermis does not give rise to Merkel cells. Finally, TDPCs possess a unique transcript profile that appears to be enforced by the juxtaposition of TDPCs with Merkel cells within the touch dome niche.

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XIX. Ueber einen bisher unbekannten Nebenapparat am Haarsystem des Menschen: Haarscheiben

Cited by 61 publications

References 0 publications

Evidence for distinct populations of human Merkel cells

Evidence for distinct populations of human Merkel cells

Sensory Innervation of the Hairless and Hairy Skin in Mammals including Humans

Identification of epidermal progenitors for the Merkel cell lineage

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