1985
DOI: 10.2165/00003495-198530040-00002
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Xipamide A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy

Abstract: Xipamide is a diuretic derived from salicylic acid and has a structural resemblance to chlorthalidone. Its pharmacodynamic profile shows a diuretic efficacy is similar to that of frusemide (furosemide) at doses up to 40 mg, but the onset and duration of action are comparable to those of hydrochlorothiazide. Xipamide has been studied mostly in the treatment of mild to moderate essential hypertension, with few controlled studies of its use in oedematous states. The efficacy of xipamide 20 to 40 mg once daily in … Show more

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Cited by 33 publications
(11 citation statements)
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“…Xipamide 52 is chemically related to salicylic acid, and although it has a powerful diuretic action similar to that of furosemide, its onset of action (about 1 h) and duration of action (often in excess of 12 h) are more akin to hydrochlorthiazide, which is a medium-acting thiazide. Its long duration of action can prove troublesome for elderly recipients, and serum potassium concentrations as low as 2.2 mmol/L have been encountered with its long-term use.…”
Section: Clinical Uses Of Diureticsmentioning
confidence: 99%
“…Xipamide 52 is chemically related to salicylic acid, and although it has a powerful diuretic action similar to that of furosemide, its onset of action (about 1 h) and duration of action (often in excess of 12 h) are more akin to hydrochlorthiazide, which is a medium-acting thiazide. Its long duration of action can prove troublesome for elderly recipients, and serum potassium concentrations as low as 2.2 mmol/L have been encountered with its long-term use.…”
Section: Clinical Uses Of Diureticsmentioning
confidence: 99%
“…We used the diuretic xipamide, which is a salicylic acid derivative chemically related to chlorthalidone; it is neither a thiazide nor a loop diuretic in its mechanism of action [11].…”
Section: Cardiovasc Drugs Ther 1991; 5:741-746mentioning
confidence: 99%
“…It is used mainly as an antihypertensive in doses of 10 to 40mg daily. Most data indicate that xipamide exerts its renal effect on the distal convoluted tubules (Prichard & Brogden 1985), eventually via a mechanism different from that of the thiazides. However, the pattern of side effects with regard to disturbances in electrolyte balance is similar to that of the thiazides.…”
Section: Xipamidementioning
confidence: 99%