Xinfuli granule alleviates metabolic remodeling through inhibition of endoplasmic reticulum stress and mitochondrial injury in heart failure

Su, Yan-Ni; Lu, Peipei; Yan, Siyu; Guo, Xuan-Tong; Ma, Jing; Guo, Caixia; Ma, Lihong

doi:10.1016/j.jep.2022.115782

Cited by 8 publications

(2 citation statements)

References 46 publications

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“…EF reflects cardiac contractile function and ejection capacity, while FS reflects the heart’s radial contractile ability [ 57 ]. In models of chronic heart failure induced by abdominal aorta constriction, renal hypertension, and coronary ligation, all groups showed a significant decrease in EF and FS, consistent with literature reports [ 58 , 59 ], indicating that increased cardiac afterload and myocardial ischemia severely affect normal cardiac ejection function, a common cause of chronic heart failure. The study results suggest that crocetin can significantly increase EF, FS, and SV, thereby improving chronic heart failure.…”

Section: Discussionsupporting

confidence: 90%

Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure

Ma,

Li,

et al. 2024

Pharmaceuticals

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Gardenia is both a food and medicine plant. It is widely used for cardiovascular protection, and its main bioactive ingredient is crocetin. This study aims to observe the therapeutic effects of crocetin on chronic heart failure in rats induced by various etiologies. It further compares the efficacy differences between preventative and treatment administration, varying dosages, and treatment durations, to provide improved guidance for medication in heart failure rats and determine which categories of chronic heart failure rats might benefit most from crocetin. Chronic heart failure models induced by abdominal aorta constriction, renal hypertension, and coronary artery ligation were constructed. By examining cardiac function, blood biochemistry, and histopathology, the study assessed the preventive and therapeutic effects of crocetin on load-induced and myocardial ischemia-induced heart failure. The results showed that in all three models, both treatment and preventative administration of crocetin significantly improved chronic heart failure in rats, especially in preventative administration. The results indicate crocetin may be beneficial for improving symptoms and functional capacity in rats with heart failure. Furthermore, long-term administration was more effective than short-term administration across all three rat models, with therapeutic onset observed over 6 weeks.

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Section: Discussionsupporting

confidence: 90%

Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure

Ma,

Li,

et al. 2024

Pharmaceuticals

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“…Initially, they were immersed in 2.5% glutaraldehyde for an overnight xation, then underwent postxation using osmium tetroxide, dehydration, embedding, sectioning, and staining. These procedures were in accordance with those previously documented in the literature (44). In order to evaluate the expression of NT-proBNP in rat serum, the serum samples obtained from the freezer at -80°C were defrosted.…”

Section: Pathological Histological Observationmentioning

confidence: 99%

Shenfu Injection Regulates Pyroptosis through the NLRP3/Caspase-1 Pathway to Improve Chronic Heart Failure

FAN,

LIAO,

HUANG

et al. 2023

Preprint

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Objective: The objective of this research is to clarify how Shenfu injection enhances chronic heart failure treatment, specifically by examining its influence on the NLRP3-Caspase-1 pathway. Methods: The chronic heart failure in rats was induced through subcutaneous administration of isoproterenol. The effectiveness of Shenfu injection was assessed by examining cardiac function using echocardiography, monitoring changes in serum N-terminal brain natriuretic peptide levels, and conducting histological analysis with HE and Masson staining to evaluate modifications in myocardial cell structure and fibrosis. To assess the protein levels associated with the NLRP3/Caspase-1 pathway, cellular pyroptosis, and myocardial ultrastructure, various techniques including Western blotting, GSDMD-N staining, TUNEL immunofluorescence dual staining, and electron microscopy were employed. Results: Shenfu injection significantly ameliorated cardiac function, myocardial arrangement, and fibrosis in chronic heart failure rats. Significantly, it substantially decreased the protein levels of NLRP3, caspase-1, IL-1β, and IL-18, along with a reduction in cellular pyroptosis positivity (P < 0.05). Under electron microscopy, the morphology appeared normal, with only partial cell membranes exhibiting pore formation. Conclusion: In summary, our research indicates that the SFI intervention improves cardiac function in the chronic heart failure model induced by isoproterenol, possibly by regulating the NLRP3/Caspase-1 pathway to reduce pyroptosis, suppress inflammatory responses, protect myocardial cells, and maintain the integrity of cellular ultrastructure.

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