Xinfeng capsule inhibits cartilage extracellular matrix degradation and inflammation in osteoarthritis by modulating circ_0032131 and miR-502-5p/TRAF2 axis
Qiao zhouqiao,
Jian Liu,
Yuedi Hu
et al.
Abstract:Clinical practice has proved that Xinfeng capsule (XFC) can effectively cure osteoarthritis (OA). In our study, we investigated the molecular mechanism and role of XFC in the treatment of OA using network pharmacology and cellular experiments. hsa_circ_0032131 was overexpressed in OA peripheral blood mononuclear cells (PBMCs). Both PBMCs and chondrocytes are cellular members of the inflammatory microenvironment in OA. To investigate the function of hsa_circ_0032131 in PBMCs stimulated chondrocytes. A series of… Show more
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