Ximenia americana L. enhances the antibiotic activity and inhibit the development of kinetoplastid parasites

Menezes, Irwin Rose Alencar de; Costa, Roger Henrique Sousa da; Boligon, Aline Augusti; Rolón, Míriam; Coronel, Cathia; Vega, Celeste; Coutinho, Henrique Douglas Melo; Costa, Maria do Socorro; Tintino, Saulo Relison; Pereira, Raimundo Luiz Silva; Albuquerque, Thaís Rodrigues de; Almeida, Jackson Roberto Guedes da Silva; Quintans‐Júnior, Lucindo José

doi:10.1016/j.cimid.2019.02.007

Cited by 14 publications

(8 citation statements)

References 28 publications

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“…A similar effect was also found when the Ximenia americana leaf extract was associated with beta-lactams and fluoroquinolones, presenting several antagonisms against S. aureus, P. aeruginosa and E. coli strains, with the exception of S. aureus in association with the antibiotic norfloxacin (82).…”

Section: Antibiotic Activity Modulatory Actionsupporting

confidence: 62%

UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria

Freitas

Campina

Costa

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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With the spread of bacterial resistance against clinically used antibiotics, natural plant-derived products are being studied as new sources of antibacterial molecules. Manilkara zapota is a common plant species in the American continent that is used as a food source. Studies show the M. zapota extract is rich in phenolic substances that can serve as basic molecules for the pharmaceutical industry. An extract from fresh M. zapota leaves was produced and tested to identify the compounds present, as well as its direct antibacterial and clinical antibiotic modulatory activities. To analyze the results, a new statistical methodology based on the Shannon-Wiener index was tested, capable of correcting distortions in heterogeneous environments. The Hydroethanolic Extract of Manilkara zapota leaves (HEMzL) presented a wide variety of phenolic products, as well as tannins, in the UPLC analysis. The extract showed direct antibacterial activity against the standard Staphylococcus aureus strain, however, it either acted antagonistically when associated with the tested antibiotics, or it did not present statistical significance when compared to the control. This demonstrates a need to be cautious when associating natural products with antibiotics for clinical use, as a hindrance to infectious treatments may occur. As for the statistical analysis mechanism tested, this proved to be effective, reducing false negatives at low antibiotic concentrations and false positives at high concentrations in the microdilution plate.

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Section: Antibiotic Activity Modulatory Actionsupporting

confidence: 62%

UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria

Freitas

Campina

Costa

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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“…The present study reports, for the first time, the potential of the hydroethanolic extract obtained from the stem bark of Ximenia americana L. in inhibiting the development of gastric lesions in different acute experimental models in mice. 2019) characterized the chromatographic profile (by high-performance liquid chromatography-HPLC) of the same extract, revealing the presence of the compounds quercitrin and caffeic acid as major components, in addition to several others, such as quercetin, rutin, gallic acid, catechin, chlorogenic acid, ellagic acid, and kaempferol [31,32]. A similar chemical composition was observed in other studies, indicating low chemical variation among the samples [14,15].…”

Section: Discussionsupporting

confidence: 57%

“…Qualitative analysis revealed the presence of various metabolite classes, including phenols, anthocyanins, anthocyanidins, flavonols, chalcones, aurones, leucoanthocyanidin, catechins, and steroids [15,31]. In previous research, our group reported the quantitative chemical profile of polyphenols in EHXA using the HPLC-DAD method, which identified significant compounds such as caffeic acid and quercitrin, as well as other phenolic derivatives, including gallic acid, chlorogenic acid, ellagic acid, and flavonoids such as catechin, rutin, quercetin, and kaempferol [31,32]. The treatment with EHXA (2000 mg/kg) caused no deaths or signs of toxicity in orally treated animals, indicating that the extract has no significant toxicity in vivo.…”

Section: Resultsmentioning

confidence: 99%

“…Discussion The present study reports, for the first time, the potential of the hydroethanolic extract obtained from the stem bark of Ximenia americana L. in inhibiting the development of gastric lesions in different acute experimental models in mice. The studies carried out by Silva et al (2018) and Costa et al (2019) characterized the chromatographic profile (by high-performance liquid chromatography-HPLC) of the same extract, revealing the presence of the compounds quercitrin and caffeic acid as major components, in addition to several others, such as quercetin, rutin, gallic acid, catechin, chlorogenic acid, ellagic acid, and kaempferol[31,32]. A similar chemical composition was observed in other studies, indicating low chemical variation among the samples[14,15].According to a previously published study, the HPLC analysis of Ximenia americana fruit pulp extract identified various phenolic compounds, including rutin, gallic acid, catechin, epicatechin, p-coumaric acid, and ferulic acid[29].…”

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confidence: 99%

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Ximenia americana L.: Chemical Characterization and Gastroprotective Effect

et al. 2023

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Ximenia americana L., popularly known in Brazil as “ameixa do-mato, ameixa-brava, and ameixa-do-sertão,” is widely used in folk medicine to treat several intestinal disorders. The present study assessed the potential mechanisms of action underlying the gastroprotective activity of the hydroethanolic extract of Ximenia americana L. (EHXA) stem bark. The acute toxicity of EHXA was estimated, and later, the gastroprotective effect in mice was assessed through acute models of gastric lesions induced by acidified or absolute ethanol and indomethacin, where the following mechanisms were pharmacologically analyzed: the involvement of prostaglandins (PG), histamine (H2) receptors, ATP-dependent potassium channels, sulfhydryl groups (SH), α2 adrenergic receptors, nitric oxide (NO), myeloperoxidase (MPO), gastric mucus production, and acetylcholine-mediated intestinal motility. Regarding toxicity, EHXA did not cause deaths or signs of toxicity (LD50 greater than or equal to 2000 mg/kg/p.o.). When the gastroprotective effect was assessed, EHXA (50, 100, and 200 mg/kg/p.o.) reduced the rate of lesions induced by acidified ethanol by 65.63; 53.66, and 58.02% in absolute ethanol at 88.91, 78.82, and 74.68%, respectively, when compared to the negative control group. In the indomethacin-induced gastric injury model, the reductions were 84.69, 55.99, 55.99, and 42.50%, respectively. The study revealed that EHXA might stimulate mucus production and reduce intestinal motility through SH groups, NO production, and activation of α2 adrenergic receptors. The results indicated that EHXA had significant gastroprotective activity in the evaluated models. However, further investigation is required to elucidate the cellular and molecular events underlying the action of EHXA components and to correlate them with the modulation of the signaling pathways, as demonstrated by the current pharmacological approach. Therefore, the results demonstrated in the present study, as well as previously reported findings, support the recommendation of using this species in traditional communities in Brazil.

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“…Traditionally, X. americana' fruits and leaves have several uses in medication as folks for humans and animals [18]. e leaves and twigs of the plant are used for fever, cold, as a solution for toothaches, as a laxative and eye lotion, and poison cure [19][20][21]. e root part of the plant is also used as a treatment for skin burns, leprosy, headaches, hemorrhoids, guinea worm attack, sleeping thickness, puffiness, and some sexually transmitted diseases [22].…”

Section: Importance Of Ximenia Americana In Different Parts Of the Worldmentioning

confidence: 99%

Ximenia americana: Economic Importance, Medicinal Value, and Current Status in Ethiopia

Kefelegn

Desta

2021

The Scientific World Journal

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Ximenia americana is one of the most valuable wild edible plants in the world. In different countries, it is utilized as food, medicine, an essential oil source, and the industrial component to other products. In Ethiopia, it was one of the most known and very important plants for a long period of time. It was utilized as food, a medicinal plant, and animal feed. It was also one of the most economically important and culturally valuable plants. But nowadays, it is not adequately available in the country due to deforestation problem in the years. In addition, its economic importance, current status, and medicinal roles are not well documented and understood. As for research studies, it is concluded that unless a collective effort is taken, the existence of this plant is under severe threat and needs to have some measures. This review article is aimed at addressing the abovelined topics in detail and to pinpoint and explain the importance and status of Ximenia americana.

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Ximenia americana L. enhances the antibiotic activity and inhibit the development of kinetoplastid parasites

Cited by 14 publications

References 28 publications

UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria

UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria

Ximenia americana L.: Chemical Characterization and Gastroprotective Effect

Ximenia americana: Economic Importance, Medicinal Value, and Current Status in Ethiopia

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