Xijiao Dihuang decoction relieves the erlotinib-induced dermatitis

Zheng, Yufeng; Zhao, Qiong; Jiang, Lin; Dai, Xiaohu; Zhu, Chi; Wang, Yujie; Fu, Hengzhi

doi:10.1016/j.yexcr.2022.113437

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…This is similar to previous findings that XJDHT can reduce erlotinib-induced dermatitis by inhibiting the increase of inflammatory cytokines and chemokines. 30 …”

Section: Discussionmentioning

confidence: 99%

Deciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation

Guo,

Gan,

et al. 2023

DDDT

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Purpose This study aims to confirm the efficacy of Xijiao Dihuang decoction (XJDHT), a classic prescription, in treating psoriasis and to explore the potential therapeutic mechanism. Methods For pharmacodynamic analysis, a mouse model of imiquimod cream (IMQ)-induced psoriasis was constructed. Active ingredients and genes of XJDHT, as well as psoriasis-related targets, were obtained from public databases. Intersecting genes (IGEs) of XJDHT and psoriasis were collected by Venn Diagram. A protein–protein interaction (PPI) network of IGEs is constructed through the STRING database. The Molecular Complex Detection (MCODE) and Cytohubba plug-ins of Cytoscape software were used to identified hub genes. In addition, we conducted enrichment analysis of IGEs using the R package clusterProfiler. Hub genes were validated via external GEO databases. The influence of XJDHT on Hub gene expression was examined by qPCR and ELISA, and molecular docking was used to evaluate the binding efficacy between active ingredients and hub genes. Results The results revealed that XJDHT possesses 92 potential genes for psoriasis, and 8 Hub genes were screened. Enrichment analysis suggested that XJDHT ameliorate psoriasis through multiple pathways, including AGE-RAGE, HIF-1, IL-17 and TNF signaling pathway. Validation data confirmed the differential expression of IL6, VEGFA, TNF, MMP9, STAT3, and TLR4. Molecular docking revealed a strong affinity between active ingredients and Hub genes. The efficacy of XJDHT in improving psoriatic lesions in model mice was demonstrated by PASI score and HE staining, potentially attributed to the down-regulation of VEGFA, MMP9, STAT3, TNF, and IL-17A, as evidenced by ELISA and qPCR. Conclusion This study employed network pharmacology and in vitro experiments to identify the potential mechanisms underlying the therapeutic effects of XJDHT on psoriasis, providing a new theoretical basis for its clinical application in the treatment of psoriasis.

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“…This is similar to previous findings that XJDHT can reduce erlotinib-induced dermatitis by inhibiting the increase of inflammatory cytokines and chemokines. 30 …”

Section: Discussionmentioning

confidence: 99%

Deciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation

Guo,

Gan,

et al. 2023

DDDT

View full text Add to dashboard Cite

show abstract

Xijiao Dihuang decoction relieves the erlotinib-induced dermatitis

Cited by 1 publication

References 41 publications

Deciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation

Deciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation

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