Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1Rβ/PI3K/Akt signaling pathway

Zeng, Jiuseng; Ji, Yafei; Luan, Fei; Hu, Jingwen; Rui, Yixing; Liu, Yao; Rao, Zhili; Liu, Rong; Zeng, Nan

doi:10.1016/j.jep.2022.115005

Cited by 33 publications

(16 citation statements)

References 43 publications

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“…ELRs benefit from characteristics such as elasticity, low thrombogenicity, self-assembly, and thermoresponsive behavior, comparable to those of natural elastin but compensate for elastin insolubility and restricted obtainability of sources (Fig. 2 ) [ 276 ]. Recently, in vitro and in vivo angiogenesis properties of ELRs have been reported [ 274 ].…”

Section: Induction Of Angiogenesis Using Scaffolds For Muscle Regener...mentioning

confidence: 99%

Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties

et al. 2023

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Muscular diseases and injuries are challenging issues in human medicine, resulting in physical disability. The advent of tissue engineering approaches has paved the way for the restoration and regeneration of injured muscle tissues along with available conventional therapies. Despite recent advances in the fabrication, synthesis, and application of hydrogels in terms of muscle tissue, there is a long way to find appropriate hydrogel types in patients with congenital and/or acquired musculoskeletal injuries. Regarding specific muscular tissue microenvironments, the applied hydrogels should provide a suitable platform for the activation of endogenous reparative mechanisms and concurrently deliver transplanting cells and therapeutics into the injured sites. Here, we aimed to highlight recent advances in muscle tissue engineering with a focus on recent strategies related to the regulation of vascularization and immune system response at the site of injury.

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Section: Induction Of Angiogenesis Using Scaffolds For Muscle Regener...mentioning

confidence: 99%

Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties

et al. 2023

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“…In lifestyle practice, exercise, environmental enrichment, and even dietary factors have been shown to enhance adult neurogenesis in animal models and can effectively alleviate depression and cognitive decline associated with animal models of mental illness ( Hueston et al, 2017 ; Ma C. L. et al, 2017 ; Gronska-Peski et al, 2021 ). Adult neurogenesis is improved by medication for the symptoms of depression ( Elder et al, 2006 ; Zeng et al, 2022 ), AD ( Ye et al, 2016 ; Stazi and Wirths, 2021 ), and stroke ( Chen et al, 2016 ), with TCM having the greatest effects on the aforementioned adult neurogenesis-related diseases. Together, these findings show that improving adult neurogenesis is indeed one of the most important ways to treat diseases.…”

Section: Adult Neurogenesis: From Neural Stem Cells To Therapymentioning

confidence: 99%

What can traditional Chinese medicine do for adult neurogenesis?

Shen

Jiang²,

Zhou

2023

Front. Neurosci.

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Adult neurogenesis plays a crucial role in cognitive function and mood regulation, while aberrant adult neurogenesis contributes to various neurological and psychiatric diseases. With a better understanding of the significance of adult neurogenesis, the demand for improving adult neurogenesis is increasing. More and more research has shown that traditional Chinese medicine (TCM), including TCM prescriptions (TCMPs), Chinese herbal medicine, and bioactive components, has unique advantages in treating neurological and psychiatric diseases by regulating adult neurogenesis at various stages, including proliferation, differentiation, and maturation. In this review, we summarize the progress of TCM in improving adult neurogenesis and the key possible mechanisms by which TCM may benefit it. Finally, we suggest the possible strategies of TCM to improve adult neurogenesis in the treatment of neuropsychiatric disorders.

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“…XYS contributes to adherence to the entire AC course, which is of great significance to the success of anti-TB treatment. Previous studies focused on revealing the mechanisms underlying the antidepressant effects of XYS ( Chen et al, 2020 ; Zeng et al, 2022 ), but there is a lack of research on the mechanisms by which XYS attenuates liver damage.…”

Section: Introductionmentioning

confidence: 99%

Xiao-Yao-San protects against anti-tuberculosis drug-induced liver injury by regulating Grsf1 in the mitochondrial oxidative stress pathway

Bai

Tao

Zhou³

et al. 2022

Front. Pharmacol.

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Background: Xiao-Yao-San (XYS) is a traditional Chinese prescription that regulates gastrointestinal function, improves mental and psychological abnormalities, and enhances liver function. However, the underlying mechanism of XYS for relieving anti-tuberculosis (AT) drug-induced liver injury is not clear.Objective: The current study examined whether XYS alleviated the symptoms of AT drug-induced liver injury in mice via the mitochondrial oxidative stress pathway.Methods: BALB/c male mice were randomly divided into four groups of 12 animals, including a control group, a model group, a 0.32 g/kg XYS group, and a 0.64 g/kg XYS group. The effect of XYS on the degree of liver injury was observed using haematoxylin and eosin staining (HE) and oil red O staining of pathological sections, biochemical parameters, and reactive oxygen species (ROS) levels. The protein expression of mitochondrial synthesis-related proteins and ferroptosis-related proteins was examined using Western blotting.Results: XYS improved the pathological changes in liver tissue and reduced the level of oxidative stress in liver-injured mice. XYS increased the expression of mitochondrial synthesis-related proteins and reversed the expression of ferroptosis-related proteins. Knockdown of G-rich RNA sequence binding factor 1 (Grsf1) expression with Grsf1 shRNA blocked the protective effects of XYS in liver injury.Conclusion: Our findings suggest that XYS alleviates AT drug-induced liver injury by mediating Grsf1 in the mitochondrial oxidative stress pathway.

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Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1Rβ/PI3K/Akt signaling pathway

Cited by 33 publications

References 43 publications

Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties

Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties

What can traditional Chinese medicine do for adult neurogenesis?

Xiao-Yao-San protects against anti-tuberculosis drug-induced liver injury by regulating Grsf1 in the mitochondrial oxidative stress pathway

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