Xiaoyao San attenuates hepatic steatosis through estrogen receptor α pathway in ovariectomized ApoE−/− mice

Hu, Tianhui; Wei, Mian; Hong, Guoping; Qi, Tingting; Xiang, Yuanyuan; Yang, Yong; Yi, Yuanyuan

doi:10.1016/j.jep.2021.114612

Cited by 8 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the hepatic lipid accumulation was more remarkable in OVX ApoE KO mice when compared with the SHAM group. Hu et al [ 27 ] demonstrated that OVX ApoE KO mice fed with a standard diet also developed an increase in these parameters. These data agree with our results since we demonstrated an increase of TAG in the plasma and liver, confirming hepatic steatosis in OVX ApoE KO mice fed a hypercholesterolemic diet (Western diet).…”

Section: Discussionmentioning

confidence: 99%

Estradiol Protects Female ApoE KO Mice against Western-Diet-Induced Non-Alcoholic Steatohepatitis

Araujo,

Cruz,

Camargo

et al. 2023

IJMS

View full text Add to dashboard Cite

The prevalence of non-alcoholic fatty liver disease (NAFLD) and its severe form, non-alcoholic steatohepatitis (NASH), is higher in men than in women of reproductive age, and postmenopausal women are especially susceptible to developing the disease. Aim: we evaluated if female apolipoprotein E (ApoE) KO mice were protected against Western-diet (WD)-induced NASH. Methods: Female ovariectomized (OVX) ApoE KO mice or sham-operated (SHAM) mice were fed either a WD or a regular chow (RC) for 7 weeks. Additionally, OVX mice fed a WD were treated with either estradiol (OVX + E2) or vehicle (OVX). Results: Whole-body fat, plasma glucose, and plasma insulin were increased and associated with increased glucose intolerance in OVX mice fed a WD (OVX + WD). Plasma and hepatic triglycerides, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) hepatic enzymes were also increased in the plasma of OVX + WD group, which was associated with hepatic fibrosis and inflammation. Estradiol replacement in OVX mice reduced body weight, body fat, glycemia, and plasma insulin associated with reduced glucose intolerance. Treatment also reduced hepatic triglycerides, ALT, AST, hepatic fibrosis, and inflammation in OVX mice. Conclusions: These data support the hypothesis that estradiol protects OVX ApoE KO mice from NASH and glucose intolerance.

show abstract

Section: Discussionmentioning

confidence: 99%

Estradiol Protects Female ApoE KO Mice against Western-Diet-Induced Non-Alcoholic Steatohepatitis

Araujo,

Cruz,

Camargo

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…XYS is one of the representative prescriptions traditionally used for gynecological diseases such as menopausal symptoms ( Chen et al, 2011 ; Lee et al, 2021 ). Some laboratory studies have demonstrated estrogen- ( Hu et al, 2022 ) and antidepressant-like effects of XYS ( Dai et al, 2010 ; Yuan et al, 2020 ). At the same time, XYS has been commonly prescribed for FD patients, especially with Disharmony of liver and spleen systems pattern .…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of Xiaoyao-san for the treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials

et al. 2023

View full text Add to dashboard Cite

Objective: Although Xiaoyao-san (XYS) is a popular herbal remedy for indigestion, there is insufficient evidence to recommend it as a treatment option for functional dyspepsia (FD). This review aimed to assess the safety and efficacy of XYS in patients with FD, compared to conventional Western medicine (WM).Methods: Two independent reviewers searched for randomized controlled trials (RCTs) using 11 electronic databases, including Medline and Embase, to evaluate therapeutic effects of XYS on FD up to 31 January 2023. The primary outcome was the total clinical efficacy rate (TCE), and secondary outcomes included scores of dyspepsia-related symptoms (DSS) and incidence of adverse events (AEs). The risk of bias was evaluated using the Cochrane collaboration tool, and data synthesis and subgroup analyses were performed using the Review Manager program.Results: Six studies involving 707 participants were included in the meta-analysis. XYS significantly improved TCE compared to WM (RR = 1.15, 95% CI: 1.05, 1.26, p = 0.002) with high heterogeneity (I2 = 59%, p = 0.06). Combination therapy also showed higher TCE than WM alone (RR = 1.22, 95% CI: 1.05, 1.41, p = 0.008), and the heterogeneity was low (I2 = 0%, p = 0.86). The results showed a greater reduction in DSS in the XYS and combination therapy groups than in the WM alone group (SMD = −0.72, 95% CI: −0.90, −0.53, p < 0.00001) with low heterogeneity (I2 = 44%, p = 0.15), especially for abdominal distension and upper abdominal pain. AEs occurred less frequently in the XYS and combination therapy groups than in the WM alone group (RR = 0.20, 95% CI: 0.07, 0.63, p = 0.006), and the heterogeneity was low (I2 = 45%, p = 0.18). The certainty of the evidence for each outcome was rated from “very low” to “high.”Conclusion: This review suggests that XYS is effective and safe for reducing complaints in patients with FD. However, high-quality RCTs should be conducted to establish more convincing therapeutic evidence of XYS for the treatment of FD.Systematic Review Registration:https://www.crd.york.ac.uk/prospero, CRD42020178842

show abstract

Resveratrol protects against postmenopausal atherosclerosis progression through reducing PCSK9 expression via the regulation of the ERα-mediated signaling pathway

Yuan

et al. 2023

Biochemical Pharmacology

View full text Add to dashboard Cite

Xiaoyao San attenuates hepatic steatosis through estrogen receptor α pathway in ovariectomized ApoE−/− mice

Cited by 8 publications

References 41 publications

Estradiol Protects Female ApoE KO Mice against Western-Diet-Induced Non-Alcoholic Steatohepatitis

Estradiol Protects Female ApoE KO Mice against Western-Diet-Induced Non-Alcoholic Steatohepatitis

Safety and efficacy of Xiaoyao-san for the treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials

Resveratrol protects against postmenopausal atherosclerosis progression through reducing PCSK9 expression via the regulation of the ERα-mediated signaling pathway

Contact Info

Product

Resources

About