Xiaotan Tongfu granules contribute to the prevention of stress ulcers

Yan, Bing; Shi, Jun; Xiu, Lijuan; Li, Xuan; Zhou, Yuqi; Feng, Shou-Han; Lv, Can; Yuan, Xiuxia; Zhang, Yincheng; Li, Yongjin; Wei, Pin‐Kang; Qin, Zhifeng

doi:10.3748/wjg.v19.i33.5473

Cited by 7 publications

(3 citation statements)

References 60 publications

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“…In the mouse cold-restraint stress model, apoptosis of gastric cells is a common pathological characteristic 16 17 . Protein levels of cleaved caspase-3, caspase-3, and Bax were measured by western blotting, and cell apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining.…”

Section: Resultsmentioning

confidence: 99%

The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities

Zhang

Wang

et al. 2016

Sci Rep

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This study evaluated the protective effects of inhibiting caspase-1 activity or gastric acid secretion on acute gastric injury in mice. AC-YVAD-CMK, omeprazole, or vehicle were administered to mice before cold-restraint stress- or ethanol-induced gastric injury. Survival rates and histological evidence of gastric injury of mice pretreated with AC-YVAD-CMK or omeprazole, and exposed to cold-restraint stress, improved significantly relative to the vehicle group. The increased levels of tumour necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-18 following cold-stress injury were decreased by AC-YVAD-CMK, but not omeprazole, pretreatment. The increased expression of CD68 in gastric tissues was inhibited significantly by AC-YVAD-CMK pretreatment. Inhibiting caspase-1 activity in the NLRP3 inflammasome decreased gastric cell apoptosis, and the expression of Bax and cleaved caspase-3. AC-YVAD-CMK pretreatment significantly inhibited cold-restraint stress-induced increases in the expression of phosphorylated IκB-alpha and P38. General anatomy and histological results showed the protective effect of AC-YVAD-CMK on ethanol-induced acute gastric injury. Overall, our results showed that the caspase-1 inhibitor AC-YVAD-CMK protected against acute gastric injury in mice by affecting the NLRP3 inflammasome and attenuating inflammatory processes and apoptosis. This was similar to the mechanism associated with NF-κB and P38 mitogen-activated protein kinase signalling pathways.

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Section: Resultsmentioning

confidence: 99%

The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities

Zhang

Wang

et al. 2016

Sci Rep

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“…Qinghuobaiduyin formula (contains extracts of Astragalus membranaceus , Lonicera japonica , Scutellaria baicalenis Georgi , Ophiopogon japonicus and Rheum rhabarbarum ) increases HSP70 levels and induces anti-apoptotic effects on the intestinal mucosa following burn injury ( Zhu et al, 2013 ). Granules of Xiaotan Tongfu promote cell proliferation, inhibit gastric mucosal cell apoptosis and local inflammation, and increase expression of HSP70 in rats with stress ulceration ( Yan et al, 2013 ).…”

Section: Tcm Regulates Expression Of Hspsmentioning

confidence: 99%

Traditional Chinese Medicine Targeting Heat Shock Proteins as Therapeutic Strategy for Heart Failure

Wang

et al. 2022

Front. Pharmacol.

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Heart failure (HF) is the terminal stage of multifarious heart diseases and is responsible for high hospitalization rates and mortality. Pathophysiological mechanisms of HF include cardiac hypertrophy, remodeling and fibrosis resulting from cell death, inflammation and oxidative stress. Heat shock proteins (HSPs) can ameliorate folding of proteins, maintain protein structure and stability upon stress, protect the heart from cardiac dysfunction and ameliorate apoptosis. Traditional Chinese medicine (TCM) regulates expression of HSPs and has beneficial therapeutic effect in HF. In this review, we summarized the function of HSPs in HF and the role of TCM in regulating expression of HSPs. Studying the regulation of HSPs by TCM will provide novel ideas for the study of the mechanism and treatment of HF.

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“…The traditional Chinese medicical theory states that weakened body resistance is the main reason behind the pathogenesis of peptic ulcer. Spleen deficiency is the main reason that causes the relapse of ulcers, and astragalus can enhance the phagocytosis of the macrophage and regulate the body's immune function. Dangshen can suppress the secretion of gastric acid and increase the expression of endogenous prostaglandin E in the stomach tissue .…”

Section: Introductionmentioning

confidence: 99%

The influence of the Chuyou Yuyang granule on the Toll‐like receptor/nuclear factor‐κB signal pathway in Helicobacter pylori‐positive peptic ulcer patients

Yang

Shen

et al. 2019

J of Cellular Biochemistry

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Background: The cure rate of Helicobacter pylori (HP)-positive peptic ulcer has appeared to downward trend, and the resistance of the ulcer relapse has become a hot issue. Methods: Hematoxylin and eosin staining was used to detect the repair of the damaged tissues in patients after treatment with the Chuyou Yuyang granule (CYYY). Elisa was used to analyze the expression of cytokine interleukin 18 (IL-18) and tumor necrosis factor α (TNF-α) in the patients' serum. Western blot analysis was used to explore the mechanism of the CYYY. Reverse-transcription polymerase chain reaction (RT-PCR) was used to detect the expression of microRNA-155a (miR-155a) and miR-146a in the blood of the patients and to confirm whether CYYY could cure peptic ulcer through regulation of miR-155a and miR-146a. Results:The damaged gastric mucosal tissues of ulcer patients were significantly repaired by treating with CYYY. The pro-inflammatory cytokine IL18 and TNF-α were notably repressed after treating with CYYY. In addition, CYYY played a key role in regulation of the Toll-like receptor (TLR4)/nuclear factor-κB (NF-κB) signal pathway and the expression of miR-155a and miR-146a.Conclusion: CYYY was a highly effective therapeutic method for peptic ulcer patients by inhibiting the activation of the TLR4/NF-κB signal pathway and suppressing the expression of miR-155a and miR-146a. K E Y W O R D SChuyou Yuyang granule, Toll-like receptor/nuclear factor-κB signal, ulcer patients J Cell Biochem. 2019;120:13745-13750.wileyonlinelibrary.com/journal/jcb

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Xiaotan Tongfu granules contribute to the prevention of stress ulcers

Abstract: The Xiaotan Tongfu granule was demonstrated to be similar to ranitidine in preventing stress ulcers. It exhibited multiple underlying mechanisms and deserves further study.

Cited by 7 publications

References 60 publications

The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities

The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities

Traditional Chinese Medicine Targeting Heat Shock Proteins as Therapeutic Strategy for Heart Failure

The influence of the Chuyou Yuyang granule on the Toll‐like receptor/nuclear factor‐κB signal pathway in Helicobacter pylori‐positive peptic ulcer patients

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