Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation

Liu, Nannan; Liu, Chengdi; Yang, Yujiao; Ma, Guodong; Wei, Guangyi; Liu, Shan; Kong, Ling-Lei; Du, Guanhua

doi:10.1016/j.phrs.2021.105650

Cited by 19 publications

(7 citation statements)

References 59 publications

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“…XXMD has a long history in China. Both clinical data and animal experimental evidence have confirmed that XXMD can effectively promote the treatment of stroke (Ye et al, 1999;Liu et al, 2021). However, based on the current research status of TCM in China, the qualities of RCT study of many Chinese herbal formulas, including XXMD, still need to be improved.…”

Section: Discussionmentioning

confidence: 99%

“…Stroke is a cerebrovascular event with cerebral blood flow interruption which is caused by occlusion or bursting of cerebral vessels. It can cause multiple functional damage of body and sustain with some complications Liu et al, 2021). In stroke and poststroke, massive formation of inflammatory cytokines glycoproteins and monocyte chemoattractant proteins (McKimmie and Graham, 2010) may cause neuronal death in different brain regions (Miyawaki et al, 2008;Ofengeim et al, 2012), In particular, neuron damage in hippocampus (hippocampal stroke) may lead to cognitive dysfunction (Liu et al, 2005;Biessels and Reagan, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, during the animal experiments, XXMD has been proved to keep mitochondrial function (Lan et al, 2018), inhibit neuroinflammation (Liu et al, 2021), and regulate lipid metabolism regulation (Jia et al, 2019), suggesting that XXMD plays an important role in the treatment of stroke. Modern pharmacological studies showed that XXMD improved the expression of MT-ND1 protein through protein hydrolysis and phosphatidylinositol signaling pathway, and protected brain mitochondrial homeostasis during chronic cerebral hypoperfusion in rats (Wang Y.-H. et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Detecting Key Functional Components Group and Speculating the Potential Mechanism of Xiao-Xu-Ming Decoction in Treating Stroke

Chen

Wang

Cai

et al. 2022

Front. Cell Dev. Biol.

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Stroke is a cerebrovascular event with cerebral blood flow interruption which is caused by occlusion or bursting of cerebral vessels. At present, the main methods in treating stroke are surgical treatment, statins, and recombinant tissue-type plasminogen activator (rt-PA). Relatively, traditional Chinese medicine (TCM) has widely been used at clinical level in China and some countries in Asia. Xiao-Xu-Ming decoction (XXMD) is a classical and widely used prescription in treating stroke in China. However, the material basis of effect and the action principle of XXMD are still not clear. To solve this issue, we designed a new system pharmacology strategy that combined targets of XXMD and the pathogenetic genes of stroke to construct a functional response space (FRS). The effective proteins from this space were determined by using a novel node importance calculation method, and then the key functional components group (KFCG) that could mediate the effective proteins was selected based on the dynamic programming strategy. The results showed that enriched pathways of effective proteins selected from FRS could cover 99.10% of enriched pathways of reference targets, which were defined by overlapping of component targets and pathogenetic genes. Targets of optimized KFCG with 56 components can be enriched into 166 pathways that covered 80.43% of 138 pathways of 1,012 pathogenetic genes. A component potential effect score (PES) calculation model was constructed to calculate the comprehensive effective score of components in the components-targets-pathways (C-T-P) network of KFCGs, and showed that ferulic acid, zingerone, and vanillic acid had the highest PESs. Prediction and docking simulations show that these components can affect stroke synergistically through genes such as MEK, NFκB, and PI3K in PI3K-Akt, cAMP, and MAPK cascade signals. Finally, ferulic acid, zingerone, and vanillic acid were tested to be protective for PC12 cells and HT22 cells in increasing cell viabilities after oxygen and glucose deprivation (OGD). Our proposed strategy could improve the accuracy on decoding KFCGs of XXMD and provide a methodologic reference for the optimization, mechanism analysis, and secondary development of the formula in TCM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Detecting Key Functional Components Group and Speculating the Potential Mechanism of Xiao-Xu-Ming Decoction in Treating Stroke

Chen

Wang

Cai

et al. 2022

Front. Cell Dev. Biol.

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“…The Encyclopedia of Traditional Chinese Medicine (ETCM; http://www.tcmip.cn/ETCM/index.php/Home/Index/) [15] and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP; https://tcmspw. com/tcmsp.php) [16] can provide comprehensive information, which is ingredients, targets and pharmacokinetic characteristics of commonly used TCM herbs and herbal formulas. In this study, we accessed the ETCM and TCMSP to predict the ADME-related properties of TMDZ capsules by searching for the chemical name "Gastrodia elata, Eucommia ulmoides (salt), Radix Aconiti Kusnezoffii, Aconitum carmichaelii Debx, Radix Angelicae Pubescentis, Ligusticum, scrophularia ningpoensis, Angelica sinensis, rehmannia, Cyathula officinalis, Viscum coloratum and Notopterygium incisum," which can collect components, targets and other relevant properties of TMDZ capsules.…”

Section: Screening Of Active Ingredients Of Tmdz Capsulesmentioning

confidence: 99%

Based on network pharmacology and molecular docking to predict the mechanism of TMDZ capsule in the treatment of IS

Yang

Yao

et al. 2023

Medicine

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Background: Ischemic stroke (IS) is the most common cardiovascular and cerebrovascular disease in clinic. Qiangli Tianma Duzhong Capsule (TMDZ capsule) has significant therapeutic effect to IS. Therefore, it is great significance to explore the mechanism of action of TMDZ capsules in the treatment of IS. Methods: The potential active components and possible targets of TMDZ capsule were obtained from TCMSP and The Encyclopedia of Traditional Chinese Medicine databases. IS related targets were collected by Genecard database, OMIM database, TTD database and DisGeNET database. The common target network of drug-diseases was constructed using Cytoscape for visualization analysis. Potential mechanisms were identified through enrichment analysis of gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Three key targets (ALB, TNF, and INS) were selected from the key networks with high correlation scores in PPI for molecular docking, through molecular docking, the interaction between target and protein is visualized. Results: 59 active components and 648 targets of TMDZ capsules and 2286 targets of IS were obtained through database mining. Compound-target network is constructed with 117 nodes and 1185 edges. GO and KEGG suggest that lipids and atherosclerosis, fluid shear forces and atherosclerosis, neurodegenerative pathways – multiple diseases and blood circulation play important roles in the treatment of IS. Conclusions: This study reveals the molecular mechanism of TMDZ capsules in the treatment of IS by integrating molecular docking with a network pharmacological strategy, which not only confirmed the clinical efficacy of TMDZ capsule, but also laid the foundation for further experimental research.

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“…Systems pharmacology provides a good opportunity for the modernization of Chinese medicine, especially the modernization of its theoretical basis ( Liao et al, 2021 ; Liu N et al, 2021 ). Systems pharmacology can quickly clarify the mechanism of multi-components in TCM that play an overall role through multiple targets and channels ( Yang et al, 2017 ; Qin et al, 2021 ; Xu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Combination of Systems Pharmacology and Experimental Evaluation to Explore the Mechanism of Synergistic Action of Frankincense-Myrrh in the Treatment of Cerebrovascular Diseases

et al. 2022

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Frankincense-Myrrh is a classic drug pair that promotes blood circulation, and eliminates blood stasis. The combination of the two drugs has a definite clinical effect on the treatment of cerebrovascular diseases (CBVDs), but its mechanism of action and compatibility have not been elucidated. In this study, the bioactive components, core targets, and possible synergistic mechanisms of Frankincense-Myrrh in the treatment of CBVDs are explored through systems pharmacology combined with in vivo and in vitro experiments. Comparing target genes of components in Frankincense and Myrrh with CBVD-related genes, common genes were identified; 15 core target genes of Frankincense-Myrrh for the treatment of CBVDs were then identified using protein-protein interaction (PPI) analysis. It was also predicted through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis that the molecular mechanism of Frankincense-Myrrh action on CBVDs was mainly related to the regulation of neurotrophic factors and inflammatory responses. Frankincense-Myrrh significantly improved neurological function, decreased infarct volume, alleviated histopathological damage, inhibited microglial expression, and promoted the expression of neurons in middle cerebral artery occlusion (MCAO)-induced rats. The results of this study not only provide important theoretical support and experimental basis for the synergistic effect of Frankincense-Myrrh, but also provide new ideas for the prevention and treatment of cerebral ischemic injuries.

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Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation

Cited by 19 publications

References 59 publications

Detecting Key Functional Components Group and Speculating the Potential Mechanism of Xiao-Xu-Ming Decoction in Treating Stroke

Detecting Key Functional Components Group and Speculating the Potential Mechanism of Xiao-Xu-Ming Decoction in Treating Stroke

Based on network pharmacology and molecular docking to predict the mechanism of TMDZ capsule in the treatment of IS

Combination of Systems Pharmacology and Experimental Evaluation to Explore the Mechanism of Synergistic Action of Frankincense-Myrrh in the Treatment of Cerebrovascular Diseases

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