XeUS: A second-generation automated open-source batch-mode clinical-scale hyperpolarizer

Cryptophane–xenon complexes for 129Xe MRI applications

“…Additionally, modern technological advancements, such as progress in generating larger quantities of isotopically enriched 129 Xe and the development of 129 Xe polarizers capable of achieving near-unity polarization levels 115,116 will likely allow for signicantly lower working concentrations of Xe and biosensor, thereby facilitating biocompatibility and lowering cost. The integration of cryptophane-based biosensors with established imaging tools such as PFOB nanodroplets 102 and LUVs, 93 and with common uorescence imaging modalities, should also aid in the transition of cryptophanes into the clinical domain.…”

Enabling Clinical Technologies for Hyperpolarized 129Xenon Magnetic Resonance Imaging and Spectroscopy

“…Theo riginally introduced LDA with FWHM of 0.20-0.30 nm was later upgraded to aL DA with FWHM of 0.154 nm. [73] Through these modifications, am aximum P Xe of 83.9 % AE 2.7 %w as achieved with a 129 Xe density of 1000 torr, while the highest DE values were achieved at ah igher 129 Xe density of 1330 torr at P Xe of 72.6 AE 1.4 %( Figure 10). [75][76][77] This polarizer was also used as at esting platform for temperature-ramped SEOP,w here faster initial build-up rates (g SEOP )c ould be achieved by starting with oven temperatures that would otherwise be too high to yield stable SEOP for the whole duration of the Xe polarization run;after an initial period (but before the onset of "Rb runaway" [31,75,78] ), the oven temperature would then be ramped down to achieve more stable SEOP and yield ahigh final polarization near what would be achieved without the ramping process,but in half the time.…”

Enabling Clinical Technologies for Hyperpolarized 129Xenon Magnetic Resonance Imaging and Spectroscopy

“…Theo riginally introduced LDA with FWHM of 0.20-0.30 nm was later upgraded to aL DA with FWHM of 0.154 nm. [73] Through these modifications, am aximum P Xe of 83.9 % AE 2.7 %w as achieved with a 129 Xe density of 1000 torr, while the highest DE values were achieved at ah igher 129 Xe density of 1330 torr at P Xe of 72.6 AE 1.4 %( Figure 10). [75][76][77] This polarizer was also used as at esting platform for temperature-ramped SEOP,w here faster initial build-up rates (g SEOP )c ould be achieved by starting with oven temperatures that would otherwise be too high to yield stable SEOP for the whole duration of the Xe polarization run;after an initial period (but before the onset of "Rb runaway" [31,75,78] ), the oven temperature would then be ramped down to achieve more stable SEOP and yield ahigh final polarization near what would be achieved without the ramping process,but in half the time.…”

“…One of the most important changes was the introduction of the highly integrated 3D printed oven featuring at hermo-electric cooling (TEC) module for temperature control of the SEOP cell (Figure 9). [71] Theredesigned SEOP cell uses apremixed Xe-containing gas mixture,r esulting in as ubstantially simplified gashandling manifold design; [73,74] operating at ac onstant positive pressure mitigates the potential for Rb in-cell oxidation otherwise caused by slow leaks between gas-reloading stages for the SEOP cell. Furthermore,a2-inch-diameter laser beam expander was integrated in the LDAd esign, which when coupled with the mechanical aligning legs of the oven assembly,a llowed for convenient alignment of the laser beam with the SEOP cell.…”