Xerostomy, dental caries and periodontal disease in HIV+ patients

Filho, Julio César Cavasin; Giovani, Élcio Magdalena

doi:10.1590/s1413-86702009000100005

Cited by 31 publications

(38 citation statements)

References 13 publications

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“…A Tabela 2 apresenta oito estudos referentes à associação entre hipofunção das glândulas salivares/xerostomia e a Terapia Antirretroviral Altamente Ativa (HAART). Três destes encontraram associação entre xerostomia e a referida terapia 1,20,21 ; dois estudaram o uso da terapia que incluía Inibidores de Protease 22,23 , sendo esta associada à xerostomia em um dos trabalhos 22 e, em outro, ao aumento das lesões bucais 23 . Um artigo mostrou associação entre a HAART e o aumento da glândula parótida 2 , sendo que outro estudo observou que a probabilidade de xerostomia era menor em pacientes que faziam uso contínuo da HAART quando comparados aos que faziam uso descontínuo da mesma terapia 24 .…”

Section: Materials E Métodounclassified

“…A Síndrome da Imunodeficiência Adquirida (AIDS) foi e ainda é uma das patologias de maior interesse para a comunidade científica 1 . A infecção pelo Vírus da Imunodeficiência Humana (HIV) é caracterizada por uma redução gradual e progressiva de linfócitos T CD4+, que, por sua vez, leva a um aumento de infecções oportunistas; estas, invariavelmente, conduzem à morte do paciente 2 .…”

Section: Introductionunclassified

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Xerostomia related to HIV infection /AIDS: a critical review

Tinós

Sales-Peres

2014

Rev. odontol. UNESP

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ResumoIntrodução: A presença de manifestações bucais em indivíduos HIV positivos é bastante comum, sendo que a xerostomia aparece como um dos problemas mais frequentes, podendo levar a uma redução na qualidade de vida dessa população. Objetivo: Este estudo objetivou realizar uma revisão crítica sobre a relação entre xerostomia e a infecção pelo HIV, a fim de despertar a atenção do cirurgião-dentista quanto à importância da atenção odontológica dirigida a esses pacientes. Material e método: Foram incluídos artigos publicados no período entre 2000 e 2009, indexados na base de dados PUBMED. Os descritores utilizados foram HIV e xerostomia, sendo adotados como critérios de exclusão: a ausência dos referidos descritores associados, a não localização do texto completo, os artigos baseados em estudos de caso ou série de casos, e a ausência do resumo na base de dados. Resultado: Com base nos estudos incluídos na revisão, pode-se afirmar que a xerostomia é uma manifestação comum da infecção pelo HIV, predispondo o paciente a vários outros problemas bucais. Dentre os fatores de risco para a sua ocorrência, foram relacionados: as baixas contagens de células T CD4+, a alta carga viral plasmática, o uso de alguns medicamentos e a terapia antirretroviral. Conclusão: A infecção pelo HIV/AIDS pode alterar as glândulas salivares. Além disso, importantes fatores de risco foram considerados para ocorrência de xerostomia: a presença da didanosina e da classe de medicamentos que corresponde aos inibidores de protease na terapia antirretroviral.Descritores: AIDS; HIV; saliva; terapia antirretroviral de alta atividade; xerostomia. Abstract Introduction:The presence of oral manifestations in HIV positive individuals is quite common. Xerostomia appears as one of the most frequent problems and may lead to a reduction in the quality of life of this population. Objective: This study was a critical review of the relationship between xerostomia and HIV infection, to attract the attention of dentists on the importance of dental care to these patients. Material and method: We included articles published between 2000 and 2009, indexed in PUBMED database. The descriptors used were "HIV" and "xerostomia", the exclusion criteria adopted were: the absence of these descriptors associated, non-location of the full-text, articles based on case studies or case series and the absence of the abstract in the database. Result: Based on studies in the review, it can be said that the xerostomia is a common manifestation of HIV infection, predisposing the patient to several other oral problems. Among the risk factors for its occurrence it was reported: low counts of CD4+ T cells, high plasma viral load, the use of some medications and antiretroviral therapy. Conclusion: The HIV/ AIDS can change the salivary glands, and were considered important risk factors for the occurrence of xerostomia the presence of didanosine and the drug class which corresponds to protease inhibitors in antiretroviral therapy.

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Section: Materials E Métodounclassified

Section: Introductionunclassified

Xerostomia related to HIV infection /AIDS: a critical review

Tinós

Sales-Peres

2014

Rev. odontol. UNESP

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“…According to studies, HIV-positive cases are more susceptible to dental caries when compared to HIV-negative ones (2, 3). The reason may be traced to the increased level of Streptococcus mutans the main pathogen associated with dental caries in HIV-positive cases compared to healthy cases (4).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the buffering capability and pH of saliva decreased significantly in these patients. This may also be considered a factor for the increased number of caries in these patients (2, 7). Today, antiretroviral therapy (ART) is prescribed to treat HIV-positive patients, sometimes for extended periods (8).…”

Section: Introductionmentioning

confidence: 99%

Dental Health Status of HIV-Positive Patients and Related Variables in Southeast Iran

Saravani

Zehi

Kadeh

et al. 2016

Int J High Risk Behav Addict

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BackgroundDifferent factors can be responsible for the increased prevalence of dental caries and missing teeth in HIV-positive patients.ObjectivesThis study evaluates dental health status and its relationship with social, behavioral, and medical factors in HIV-positive patients under the coverage of Zahedan University of Medical Sciences in Southeast Iran.Patients and MethodsIn a cross-sectional study, the dental health status of 119 HIV-positive patients was assessed in accordance with WHO indices and included decayed, missing, and filled teeth (DMFT). A questionnaire on different social, behavioral, and medical variables was filled out for every case and the relationship and correlation of the variables to dental health status were investigated using One-way ANOVA, the Kruskal Wallis test, the t-test, the Mann-Whitney test, Spearman’s rho correlation coefficient, and Pearson correlation.ResultsThe mean value of DMFT index was 11.87 ± 8.08, where the mean values of decayed and missing teeth were 8.42 ± 5.44 and 3.43 ± 4.07, respectively. DMFT index, decayed, and missing teeth correlated only with age (P < 0.0001, P = 0.009, P < 0.0001) and duration of HIV involvement (P = 0.004, P = 0.031, P = 0.007).ConclusionsThe dental health status of HIV-positive patients in this region was almost inappropriate. Most social, behavioral, and medical factors had no influence on dental health; only a correlation between dental health, age, and duration of HIV involvement was observed.

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“…Jeganathan et al [15] found that the patient's age and the duration of the HIV infection determine the occurrence of mouth dryness, which in turn is reflected by higher severity of caries and overall deterioration of the quality of life. Chronic inflammation of the salivary glands is observed despite implementation of anti-retroviral therapy, radically inhibiting the secretion of saliva and increasing the dryness of the oral mucosa [17].…”

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confidence: 99%