Xerostomia, Hyposalivation, and Salivary Flow in Diabetes Patients

López‐Pintor, Rosa María; Casañas, Elisabeth; González‐Serrano, José; Serrano, Julia; Ramı́rez, Lucı́a; Arriba, Lorenzo de; Hernández, Gonzalo

doi:10.1155/2016/4372852

Cited by 136 publications

(117 citation statements)

References 26 publications

(90 reference statements)

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“…The reduced availability of such a protective factor could be linked to the inadequate preservation of mouth tissues and the consequent high incidence of caries and oral infections reported in diabetic subjects. Other studies have shown altered protein concentrations and a decreased salivary flow in diabetic patients (L opez-Pintor et al, 2016). Melatonin itself seems to stimulate secretion by salivary glands, as revealed by melatonin-induced morphological changes in acinar cells of human parotid glands, which have been associated with exocytotic activity, and, ultimately, in protein secretion (Loy et al, 2015).…”

Section: Discussionmentioning

confidence: 97%

Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands

Isola

Lilliu

Loy

et al. 2017

The Anatomical Record

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Recently we reported on the detailed localization of melatonin (and its receptors) in human salivary glands, revealing that serous cells are able to store and secrete melatonin into saliva. Since we found that type 2 diabetic patients display reduced melatonin content in saliva, our next step was to examine the presence of melatonin in salivary glands removed from type 2 diabetic subjects. The resulting data were compared with those previously obtained by identical procedures in non-diabetics, to establish if the diabetic status may affect melatonin distribution. Bioptic samples of diabetic parotid and submandibular glands were fixed, dehydrated, embedded in Epon Resin and processed to demonstrate melatonin reactivity by the immunogold staining method. The labeling density (expressed as the number of gold particles per μm /granule) and the percentage of melatonin-positive granules were assessed in diabetic samples. These values were compared with those in non-diabetic samples and differences were evaluated. In parotid and submandibular diabetic glands the reactivity for melatonin was specifically associated with secretory granules and small vesicles in serous cells. Melatonin reactivity was higher in parotid than in submandibular glands. Our data were in line with those obtained in our previous study on non-diabetic glands. Diabetic salivary glands showed a higher labeling density and a lower number of melatonin-positive granules compared to non-diabetic glands. Taken together, these data might explain the decreased salivary melatonin content and the associated oral problems observed in diabetics. Anat Rec, 301:711-716, 2018. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 97%

Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands

Isola

Lilliu

Loy

et al. 2017

The Anatomical Record

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“…So diabetes is one of the main causes for oral hygiene and destruction of the teeth. 7 Cortelli et al in their study evaluate the impact of gingivitis treatment on oral health and quality of life. This treatment can improve quality of life and emphasize the relevance of periodontal care for individual's daily life.…”

Section: Discussionmentioning

confidence: 99%

To Study the Dental Conditions in Diabetes Mellitus Patients

Kumeti¹,

Kashyap²

2019

jebmh

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BACKGROUNDPeriodontal disease is a chronic inflammatory condition and is now considered as the sixth complication of diabetes and also one of the major oral complications of diabetes mellitus. Oral health is associated with various systemic conditions such as diabetes, cardiovascular disorders etc. The main objective is to study the dental conditions in diabetes mellitus patients. RESULTSOut of 78 Cases, there were 10 males and 5 females in 35 -40 years age group. 15 males and 10 females were present in 40 -50 years age group. 20 males and 18 females were present in 50 -60 years age group. 15 cases of tobacco intake with 19.23%, 18 cases of sugar intake with 23.07%, 30 cases of poor tooth brushing with 38.46% and 15 cases due to local irritants with 19.23% were seen. CONCLUSIONSHealth care professionals should play an important role in preventing and controlling periodontal disease. Diabetic patients should regularly visit a dentist in order to reduce oral complications. Health care professionals and diabetic patients should emphasize necessary provisions in order to prevent this disease.

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“…[11][12][13] The reduction of salivary gland secretion may also be caused by the occurrence of endocrinopathy (diabetes, thyroid disease), autoimmune diseases (Sjögren's syndrome, rheumatoid arthritis, systemic lupus erythematosus, scleroderma), granulomatous diseases, and local causes (head and neck radiotherapy, salivary gland diseases). 11,14,15 Xerostomia has certain effects on the emotional state of the elderly, leading to a low mood and depressive states. Both subjective and objective complaints associated with dry mouth reduce the quality of life of geriatric patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of oral mucosal lesions in young seniors in the Wrocław region

Głowacka

Konopka

2018

Dent. Med. Probl.

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Background. The morbidity of certain oral pathologies, for example denture-related stomatitis, burning mouth syndrome (BMS) and benign neoplasms is higher in the elderly. It is necessary to periodically assess the changes in the profile of the occurrence of these diseases and determine the dominant risk factors associated with their incidence.Objectives. The aim of the study was to evaluate the prevalence of oral mucosal pathologies (in particular, potentially malignant and cancerous disorders) in a randomly selected population of 65-74-year-old residents of Wrocław and Oława, Poland. Material and methods.A group of 1,600 persons aged 65-74 years, living in Wrocław (a large city) and Oława (a small town) were randomly selected to participate in the study. 285 people from Wrocław and 102 from Oława were examined. In a clinical dental examination, the following parameters were assessed: the number of teeth; probing/pocket depth (PD) and clinical attachment level (CAL) for all the teeth at 4 measuring points (on this basis, periodontal diagnoses were made according to American recommendations -of the American Center for Disease Control and Prevention and the American Academy of Periodontology (CDC/AAP)); and the presence of prosthetic restorations and their quality. In the anamnestic study, variables concerning the socioeconomic status, systemic conditions (comorbidity of selected general diseases, nicotine addiction status, body mass) and selected behaviors promoting oral health were determined.Results. The most common clinical changes in the oral mucosa were denture-related stomatitis (6.7%), hemangiomas (5.9%) and fibromas (4.1%). Potentially malignant disorders and cancerous lesions were diagnosed in 59 persons (15.2% of the respondents). One case of tongue cancer was diagnosed in an inhabitant of Oława. Conclusions.More than 1/3 of the examined persons were diagnosed with certain clinical, pathological oral mucosal lesions requiring treatment, of which nearly half were potentially malignant and cancerous. Poor tooth brushing efficiency was associated with a higher incidence of pre-cancerous and cancerous lesions in the oral cavity.Słowa kluczowe: osoby starsze, choroby błony śluzowej jamy ustnej, zaburzenia potencjalnie złośliwe, przekrojowe badanie epidemiologiczne Cite asGłowacka B, Konopka T. Prevalence of oral mucosal lesions in young seniors in the Wroclaw region. Dent Med Probl.

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Xerostomia, Hyposalivation, and Salivary Flow in Diabetes Patients

Cited by 136 publications

References 26 publications

Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands

Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands

To Study the Dental Conditions in Diabetes Mellitus Patients

Prevalence of oral mucosal lesions in young seniors in the Wrocław region

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