Xenotransplantation of human decay accelerating factor transgenic porcine kidney to non-human primates: 4 years experience at a Canadian center

Genetic engineering of pigs to provide organs for xenotransplantation

“…Some recipients demonstrated donor-specific unresponsiveness in mixed-lymphocyteresponse assays performed after immunosuppression had been stopped. These results compare favourably with the mean of 15 days' survival reported by Brenner et al [39] and 20 days by Garcia et al [40 ], both of whom transplanted hCD55-transgenic kidneys without thymus, although they were also using different immunosuppressive regimens.…”

Expression of the Decay-Accelerating Factor (CD55) in Renal Transplants—A Possible Prediction Marker of Allograft Survival

“…It has been demonstrated in animal models that xenotransplantation of porcine kidneys and hearts, transgenic for human CD55, to nonhuman primates results in significantly increased graft survival when compared with wild-type xenografts (19,20). Increased CD55 baseline expression was correlated with better graft survival and less prominent acute humoral xenograft rejection in renal xenotransplantation (21).…”

The Influence of Baseline Expression of Human Decay Accelerating Factor Transgene on Graft Survival and Acute Humoral Xenograft Rejection

“…The animals that died of causes other than renal failure had either grade I or no evidence of AXHR in their grafts. The detailed clinical outcomes of these cases have been previously reported (13,15,18). Figure 1 represents the median survival of recipients with hDAF pig kidney grafts.…”

“…All recipients received steroids. The details of the immunosuppressive protocols were previously described (13,15,18) and listed in Table 1.…”